Methyl 2-(hydroxymethyl)isonicotinate
- Product Name
- Methyl 2-(hydroxymethyl)isonicotinate
- CAS No.
- 58481-17-7
- Chemical Name
- Methyl 2-(hydroxymethyl)isonicotinate
- Synonyms
- Methyl 2-(hydroxyMethyl) isonicotinate;2-Hydroxymethyl-isonicotinic acid methyl ester;Methyl 2-(hydroxymethyl)pyridine-4-carboxylate;2-(hydroxymethyl)-4-Pyridinecarboxylic acid methyl ester;4-Pyridinecarboxylic acid, 2-(hydroxyMethyl)-, Methyl ester;2-(Hydroxymethyl)Isonicotinic Acid 2(HYDROXYMETHYL)4PYRIDINECARBOXYLIC ACID
- CBNumber
- CB71558141
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 58481-17-7.mol
Methyl 2-(hydroxymethyl)isonicotinate Property
- Boiling point:
- 304.2±32.0 °C(Predicted)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.20±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y9548
- Product name
- 2-(Hydroxymethyl)pyridine-4-carboxylicacid
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- CHM0098187
- Product name
- 2-HYDROXYMETHYL-ISONICOTINIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.53
- Updated
- 2021/12/16
- Product number
- 126639
- Product name
- Methyl2-(hydroxymethyl)isonicotinate
- Purity
- >95%
- Packaging
- 1g
- Price
- $1404
- Updated
- 2021/12/16
- Product number
- CHM0098187
- Product name
- 2-HYDROXYMETHYL-ISONICOTINIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $997.5
- Updated
- 2021/12/16
- Product number
- CM121034
- Product name
- Methyl2-(Hydroxymethyl)pyridine-4-carboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $1328
- Updated
- 2021/12/16
Methyl 2-(hydroxymethyl)isonicotinate Chemical Properties,Usage,Production
Synthesis
The reaction was performed in 2 separate 1000 mL round-bottomed flasks. To a solution of methyl isonicotinate (70 g, 510.44 mmol) and sulfuric acid (2.340 mL, 43.90 mmol) in MeOH (700 mL) under reflux added a solution of ammonium peroxydisulfate (210 g, 918.80 mmol) in water (350 mL) over 20 min. The reaction was refluxed for 20 min and was then allowed to cool to room temperature. The solid was filtered off and washed with MeOH. After that, MeOH was removed from the filtrate under reduced pressure and then neutralized by cautious stepwise addition of solid Na2CO3 under ice-cooling. The aqueous solution was extracted with ethyl acetate and the combined organic layers were dried with Na2SO4 and evaporated. The dark-brown residue was treated with cyclohexane (3×300 mL) and the cyclohexane phase was decanted. The remaining dark-brown residue was purified by automated flash chromatography on 2 Biotage KP-SIL 340 g columns. A gradient from 25% to 100% of EtOAc in heptane over 10 CV was used as the mobile phase. Methyl 2-(hydroxymethyl)isonicotinate (27.5 g, 32%) was isolated.
Methyl 2-(hydroxymethyl)isonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-(hydroxymethyl)isonicotinate Suppliers
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View Lastest Price from Methyl 2-(hydroxymethyl)isonicotinate manufacturers
- Product
- 2-Hydroxymethyl-isonicotinic acid methyl ester 58481-17-7
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08