ChemicalBook > CAS DataBase List > 1,2,3-Trifluoro-4-nitrobenzene

1,2,3-Trifluoro-4-nitrobenzene

Uses

Product Name: 1,2,3-Trifluoro-4-nitrobenzene
CAS No.: 771-69-7
Chemical Name: 1,2,3-Trifluoro-4-nitrobenzene
Synonyms: 2,3,4-TRIFLUORONITROBENZENE;1,2,3-Trifluoro-4-ni;4-chloro-2-fluroaniline;4-Trifluoronitrobenzene;2,3,4-Trifluornitrobenzene;3,4,5 TRIFLUORONITROBENZEN;2,3,4-TRIFLUORONITROBRNZENE;1,2,3-Trifluor-4-nitrobenzol;2,3-Trifluoro-4-nitrobenzene;1-nitro-2,3,4-trifluorobenzene
CBNumber: CB7155826
Molecular Formula: C6H2F3NO2
Formula Weight: 177.08
MOL File: 771-69-7.mol

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1,2,3-Trifluoro-4-nitrobenzene Property

Boiling point:: 92 °C/20 mmHg (lit.)
Density: 1.541 g/mL at 25 °C (lit.)
refractive index: n20/D 1.492(lit.)
Flash point:: 200 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Light yellow to Yellow to Orange
Specific Gravity: 1.541
BRN: 2449746
InChI: InChI=1S/C6H2F3NO2/c7-3-1-2-4(10(11)12)6(9)5(3)8/h1-2H
InChIKey: ARCACZWMYGILNI-UHFFFAOYSA-N
SMILES: C1(F)=CC=C([N+]([O-])=O)C(F)=C1F
CAS DataBase Reference: 771-69-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39-24/25
RIDADR: UN2810
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29042090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 338362
Product name: 2,3,4-Trifluoronitrobenzene
Purity: 99%
Packaging: 25g
Price: $29
Updated: 2023/06/20

TCI Chemical

Product number: T1539
Product name: 2,3,4-Trifluoronitrobenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: T1539
Product name: 2,3,4-Trifluoronitrobenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $79
Updated: 2025/07/31

TRC

Product number: T896260
Product name: 2,3,4-Trifluoronitrobenzene
Packaging: 5g
Price: $45
Updated: 2021/12/16

TRC

Product number: T896260
Product name: 2,3,4-Trifluoronitrobenzene
Packaging: 10g
Price: $60
Updated: 2021/12/16

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1,2,3-Trifluoro-4-nitrobenzene Chemical Properties,Usage,Production

Uses

2,3,4-Trifluoronitrobenzene is a useful research chemical.

Chemical Properties

clear yellow liquid after melting

Uses

2,3,4-Trifluoronitrobenzene was employed as starting reagent in the synthesis of ofloxacin. It was also used in the synthesis of the third generation quinolones antibacterial drugs.

General Description

2,3,4-Trifluoronitrobenzene is a fluoronitrobenzene and its biotransformation under methanogenic conditions has been studied by semicontinuous and batch tests. 2,3,4-Trifluoronitrobenzene is an important pharmaceutical intermediate.

Synthesis

17700-09-3

771-69-7

General procedure for the synthesis of 2,3,4-trifluoronitrobenzene from 2,3,4-trichloronitrobenzene: (2) 240 g of DMSO and 120 g of 2,3,4-trichloronitrobenzene were added to an anhydrous reaction flask with stirring turned on, and the temperature was raised to 75-80 °C under reduced pressure with continuous stirring for 2 hours. Subsequently, 76.8 g of KF and 12 g of TBAB were added to the reaction system and dehydrated under reduced pressure at 75-80 °C for 2 h until no droplets of water fell from the distillation head. (3) The reaction system was slowly warmed up to 180 °C to start the reaction. The reaction process was monitored by gas chromatography (GC), and the reaction was completed when the content of both 2-fluoro-3,4-dichloronitrobenzene and 2,3-dichloro-4-fluoronitrobenzene decreased to less than 0.2% after 10 h. The reaction was completed when the content of 2-fluoro-3,4-dichloronitrobenzene and 2,3-dichloro-4-fluoronitrobenzene dropped below 0.2%. The reaction mixture was cooled to 70-75 °C, filtered, and the filtrate was vacuum distilled and reintroduced into the anhydrous reaction unit. 46 g of KF and 12 g of TBAF were added and dehydrated under reduced pressure at 75-80 °C for 2 h until no water droplets appeared in the distillation head. The reaction temperature was set to 120 °C and ultrasonic power to 20 kHz and the reaction was continued. The reaction was monitored by GC and completed after 2 hours. The reaction mixture was cooled to 70-75°C and filtered and the filtrate was distilled to separate DMSO from the product. The final yield of 2,3,4-trifluoronitrobenzene was 99.7%.

References

[1] Patent: CN107325001, 2017, A. Location in patent: Paragraph 0028-0029; 0031-0034; 0036-0039; 0041-0044; 0046

1,2,3-Trifluoro-4-nitrobenzene Preparation Products And Raw materials

Raw materials

Potassium fluoride Sulfanilamide Fluoroboric acid Hydrochloric acid Nitric acid 2,5-Dichloroaniline 2,6-Dichloroaniline

Preparation Products

RUFLOXACIN 2,3,4-Trifluorobenzenamine Lomefloxacin Levofloxacin Lomefloxacin hydrochloride Ofloxacin

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View Lastest Price from 1,2,3-Trifluoro-4-nitrobenzene manufacturers

.GZ HONESTCHEM CO.,LTD

Product: 1,2,3-Trifluoro-4-nitrobenzene 771-69-7
Price: US $1.00/g
Min. Order: 300g
Purity: 99.8%
Supply Ability: 20 TONS
Release date: 2025-11-04

Shaanxi Dideu New Materials Co. Ltd

Product: 1,2,3-Trifluoro-4-nitrobenzene 771-69-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-09-28

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,2,3-Trifluoro-4-nitrobenzene 771-69-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

771-69-7, 1,2,3-Trifluoro-4-nitrobenzeneRelated Search:

3,4-Difluoronitrobenzene 3-Chloro-4-fluoronitrobenzene 4-Bromo-1-fluoro-2-nitrobenzene 1-Fluoro-2-nitrobenzene Sodium 3-nitrobenzenesulphonate 2,3,4-TRICHLORONITROBENZENE 2,6-Difluoronitrobenzene 4-Fluoronitrobenzene Nitrobenzene 2,3,4,5-Tetrafluoronitrobenzene 2,3,4,5-TETRAFLUORO-6-NITROBENZOIC ACID PENTAFLUORONITROBENZENE 2,3,4,6-TETRAFLUORONITROBENZENE 1,2,3-TRIFLUORO-5-NITROBENZENE,1,2,3-Trifluoro-5-nitrobenzene, 1-Nitro-3,4,5-trifluorobenzene 2,4,6-TRINITROBENZENESULFONIC ACID 2-Fluoro-5-nitrobenzotrifluoride 2,4,5-Trifluoro-1-nitrobenzene,1,2,4-TRIFLUORO-5-NITROBENZENE,1,2,4-Trifluoro-5-nitrobenzene, 5-Nitro-1,2,4-trifluorobenzene,2,4,5-Trifluoro-5-nitrobenzene 2,4,6-Trifluoro-1-nitrobenzene,1,3,5-TRIFLUORO-2-NITROBENZENE

3,4,5 TRIFLUORONITROBENZEN

2,3,4-Trifluornitrobenzene

4-chloro-2-fluroaniline

2,3,4-TRIFLUORONITROBRNZENE

1-nitro-2,3,4-trifluorobenzene

2,3,4-Trifluoronitrobenzene 99%

2,3,4-Trifluoronitrobenzene99%

2,3,4-TRIFLUORONITROBENZENEOFLOXACIN

1,2,3-Trifluoro-4-nitrobenzene, 4-Nitro-1,2,3-trifluorobenzene

Benzene, 1,2,3-trifluoro-4-nitro-

1,2,3-Trifluoro-4-nitrobenzene,97%

1,2,3-Trifluoro-4-ni

4-Trifluoronitrobenzene

4-NITRO-1,2,3-TRIFLUOROBENZENE

1,2,3-TRIFLUORO-4-NITROBENZENE

2,3,4-TRIFLUORONITROBENZENE

2,3,4-TRIFLUORO-1-NITROBENZENE

1,2,3-Trifluoro-4-nitrobenzene ISO 9001：2015 REACH

1,2,3-Trifluor-4-nitrobenzol

2,3-Trifluoro-4-nitrobenzene

771-69-7

71-69-7

C6H2NO2F3

C6H2F3NO2

Nitrogen Compounds

Organic Building Blocks

Nitro Compounds

Building Blocks

Fluorine series

blocks

FluoroCompounds

NitroCompounds

Aromatic Hydrocarbons (substituted) & Derivatives

API intermediates

OLED