4-bromo-2-methoxy-1-nitrobenzene
- Product Name
- 4-bromo-2-methoxy-1-nitrobenzene
- CAS No.
- 103966-66-1
- Chemical Name
- 4-bromo-2-methoxy-1-nitrobenzene
- Synonyms
- 5-Bromo-2-nitroanisole;ArgatrobanImpurity91;5-Bromo-2-nitroanisoL;5-bromo-2-nitroailsole;2-Nitro-5-bromoanisole;3-Methoxy-4-nitrobromobenzene;4-Bromo-2-methoxynitrobenzene;4-bromo-2-methoxy-1-nitrobenzene;5-Bromo-1-methoxy-2-nitrobenzene;5-Bromo-2-nitrophenyl methyl ether
- CBNumber
- CB71559395
- Molecular Formula
- C7H6BrNO3
- Formula Weight
- 232.03
- MOL File
- 103966-66-1.mol
4-bromo-2-methoxy-1-nitrobenzene Property
- Melting point:
- 91-92℃
- Boiling point:
- 298.7±20.0 °C(Predicted)
- Density
- 1.640
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C7H6BrNO3/c1-12-7-4-5(8)2-3-6(7)9(10)11/h2-4H,1H3
- InChIKey
- DJKPQYBFSAJUBS-UHFFFAOYSA-N
- SMILES
- C1([N+]([O-])=O)=CC=C(Br)C=C1OC
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 7/9-22-36/37/39-51
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2909303890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 728977
- Product name
- 5-Bromo-2-nitroanisole
- Purity
- 95%
- Packaging
- 500mg
- Price
- $91.4
- Updated
- 2025/07/31
- Product number
- B688143
- Product name
- 5-Bromo-2-nitroanisole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B688143
- Product name
- 5-Bromo-2-nitroanisole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 041247
- Product name
- 4-Bromo-2-methoxy-1-nitrobenzene
- Purity
- 95%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- OR30931
- Product name
- 5-Bromo-2-nitroanisole
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
4-bromo-2-methoxy-1-nitrobenzene Chemical Properties,Usage,Production
Uses
4-Bromo-2-methoxy-1-nitrobenzene (4BMN) is a nucleophile that can be used to optimize the safety profiles of drugs.
Synthesis
321-23-3
124-41-4
103966-66-1
GENERAL STEPS: To a solution of 4-bromo-2-fluoro-1-nitrobenzene (2.0 g, 9.09 mmol) in methanol (50 mL) was added a methanolic solution of 30% sodium methanolate (1.64 g, 9.09 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in water (30 mL) and extracted with ethyl acetate (2 x 30 mL). The organic phases were combined, washed with water, separated, dried over anhydrous magnesium sulfate, filtered, and the solvent was evaporated under reduced pressure to give 5-bromo-2-nitroanisole as a crystalline solid (2.1 g, 99% yield).1H-NMR (DMSO-d6): δ [ppm] 7.9 (d, 1H), 7.6 (s, 1H), 7.3 (d, 1H), 4.0 (s, 3H).
References
[1] Patent: WO2006/40182, 2006, A1. Location in patent: Page/Page column 168
[2] Patent: CN106187838, 2016, A. Location in patent: Paragraph 0309; 0310; 0311
[3] Patent: US2012/277220, 2012, A1. Location in patent: Page/Page column 17
[4] PLoS ONE, 2017, vol. 12, # 8,
[5] Patent: US2017/8889, 2017, A1. Location in patent: Paragraph 0207; 0208
4-bromo-2-methoxy-1-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-bromo-2-methoxy-1-nitrobenzene manufacturers
- Product
- 4-bromo-2-methoxy-1-nitrobenzene 103966-66-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-16