PHENOL, 5-BROMO-2-NITRO-
- Product Name
- PHENOL, 5-BROMO-2-NITRO-
- CAS No.
- 27684-84-0
- Chemical Name
- PHENOL, 5-BROMO-2-NITRO-
- Synonyms
- 5-bromo-2-ntrophenol;5-Bromo-2-nitrophenol;3-Bromo-6-nitrophenol;2-Nitro-5-bromophenol;PHENOL, 5-BROMO-2-NITRO-;5-Bromo-2-nitrophenol 98%;5-Bromo-2-nitrophenol, 96%,;5-BroMo-2-nitrophenol, 97+%;4-Bromo-2-hydroxynitrobenzene
- CBNumber
- CB2464293
- Molecular Formula
- C6H4BrNO3
- Formula Weight
- 218
- MOL File
- 27684-84-0.mol
PHENOL, 5-BROMO-2-NITRO- Property
- Melting point:
- 40-420C
- Boiling point:
- 264.6±20.0 °C(Predicted)
- Density
- 1.881±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in ethyl acetate and methanol.
- pka
- 6.08±0.13(Predicted)
- form
- Crystalline Solid
- color
- Pale yellow
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37-60
- RIDADR
- 2811
- HS Code
- 29089990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5788
- Product name
- 5-Bromo-2-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $71
- Updated
- 2025/07/31
- Product number
- B5788
- Product name
- 5-Bromo-2-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $284
- Updated
- 2025/07/31
- Product number
- B686258
- Product name
- 5-Bromo-2-nitrophenol
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- JK575561
- Product name
- 5-Bromo-2-nitrophenol
- Purity
- 95%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CS-W003014
- Product name
- 5-Bromo-2-nitrophenol
- Purity
- 99.95%
- Packaging
- 10g
- Price
- $50
- Updated
- 2021/12/16
PHENOL, 5-BROMO-2-NITRO- Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
It is used as pharmaceutical intermediate.
Synthesis
591-20-8
27684-84-0
Potassium nitrate (51.5 g, 509 mmol) was slowly added to a mixed solution of concentrated sulfuric acid (32.6 mL) and water (105 mL) at 10 °C. The reaction mixture was stirred for 5 min and then 3-bromophenol (49.35 g, 285 mmol) was added dropwise while the reaction temperature was controlled to be maintained at about 10 °C. After addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction solution was diluted with water (350 mL) and subsequently extracted with ether. The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (silica gel, 19:1 hexane/ethyl acetate) to afford 5-bromo-2-nitrophenol (11.3 g, 18% yield) as a yellow-green solid. Its 1H NMR (DMSO-d6, 300 MHz) data were as follows: δ 11.44 (s, 1H), 7.84 (d, J = 8.7 Hz, 1H), 7.33 (d, J = 2.1 Hz, 1H), 7.18 (dd, J = 8.7, 2.1 Hz, 1H).
References
[1] Chemistry - A European Journal, 2011, vol. 17, # 33, p. 9076 - 9082
[2] European Journal of Medicinal Chemistry, 2012, vol. 56, p. 108 - 119
[3] Journal of Organic Chemistry, 1990, vol. 55, # 9, p. 2736 - 2742
[4] Patent: WO2011/44134, 2011, A1. Location in patent: Page/Page column 107
[5] Patent: EP1956013, 2008, A1. Location in patent: Page/Page column 37
PHENOL, 5-BROMO-2-NITRO- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PHENOL, 5-BROMO-2-NITRO- manufacturers
- Product
- PHENOL, 5-BROMO-2-NITRO- 27684-84-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08