2-NITRO 5-BROMO-BENZALDEHYDE
- Product Name
- 2-NITRO 5-BROMO-BENZALDEHYDE
- CAS No.
- 20357-20-4
- Chemical Name
- 2-NITRO 5-BROMO-BENZALDEHYDE
- Synonyms
- CU48750000;5-Bromo-2-nitrobenzaL;5-BROMO-2-NITRO-BENZALDEHYDE;2-NITRO 5-BROMO-BENZALDEHYDE;Benzaldehyde, 5-broMo-2-nitro-;5-Bromo-2-nitrobenzaldehyde >2-Nitro 5-Bromo-Benzaldehyde,>97%
- CBNumber
- CB0115885
- Molecular Formula
- C7H4BrNO3
- Formula Weight
- 230.02
- MOL File
- 20357-20-4.mol
2-NITRO 5-BROMO-BENZALDEHYDE Property
- Melting point:
- 71.0 to 75.0 °C
- Boiling point:
- 330.5±27.0 °C(Predicted)
- Density
- 1.781±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Light red to Green
- λmax
- 276nm(CH3CN)(lit.)
- InChI
- InChI=1S/C7H4BrNO3/c8-6-1-2-7(9(11)12)5(3-6)4-10/h1-4H
- InChIKey
- UFRVBZVJVRHSNR-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(Br)=CC=C1[N+]([O-])=O
- CAS DataBase Reference
- 20357-20-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B4192
- Product name
- 5-Bromo-2-nitrobenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- B4192
- Product name
- 5-Bromo-2-nitrobenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- B686160
- Product name
- 2-Bromo-5-nitrobenzaldehyde
- Packaging
- 2.5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 066998
- Product name
- 5-Bromo-2-nitrobenzaldehyde
- Purity
- >95%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
- Product number
- CS-W004818
- Product name
- 5-Bromo-2-nitrobenzaldehyde
- Purity
- 99.99%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
2-NITRO 5-BROMO-BENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-Bromo-5-nitrobenzaldehyde is a cholesteryl ester transfer protein (CETP) inhibitor. 2-Bromo-5-nitrobenzaldehyde is a commonly used reactant for the synthesis of (-)-Linarinic acid derivatives as neuroprotective agents against oxygen glucose deprivation (OGD)-??induced cell damage.
Synthesis
3132-99-8
20357-20-4
1. Concentrated nitric acid (10 mL) is slowly added dropwise to a solution of concentrated sulfuric acid (120 mL) containing 3-bromobenzaldehyde (11.7 mL, 100 mmol) at 5°C. The reaction system is allowed to come to room temperature with continuous stirring overnight. 2. The reaction system was allowed to warm naturally to room temperature with continuous stirring overnight. 3. The reaction mixture was slowly poured into ice water and the resulting precipitate was collected by filtration. 4. 4. The precipitate was dissolved in dichloromethane, dried by adding anhydrous magnesium sulfate, and the solvent was subsequently concentrated under reduced pressure. 5. The crude product was purified by fast column chromatography on silica gel with 25% ethyl acetate/isohexane as eluent to afford the target compound 5-bromo-2-nitrobenzaldehyde (16g, 70% yield). 6. The product NMR hydrogen spectral data (500 MHz, CDCl3): δ 10.41 (1H, s), 8.06 (1H, d, J = 2.1 Hz), 8.02 (1H, d, J = 8.6 Hz), 7.87 (1H, dd, J = 2.1,8.6 Hz).
References
[1] Chemistry - A European Journal, 2013, vol. 19, # 7, p. 2442 - 2449
[2] Patent: CN105669566, 2016, A. Location in patent: Paragraph 0027; 0028; 0029; 0030; 0031
[3] Journal of Organic Chemistry, 2014, vol. 79, # 17, p. 7822 - 7830
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 33, p. 6115 - 6122
[5] Patent: WO2006/100519, 2006, A1. Location in patent: Page/Page column 16-17
2-NITRO 5-BROMO-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-NITRO 5-BROMO-BENZALDEHYDE manufacturers
- Product
- 5-Bromo-2-nitrobenzaldehyde 20357-20-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 5-Bromo-2-nitrobenzaldehyde 20357-20-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2-NITRO 5-BROMO-BENZALDEHYDE 20357-20-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11