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5-Trifluoromethyl-pyridine-2-carbaldehyde

Product Name
5-Trifluoromethyl-pyridine-2-carbaldehyde
CAS No.
31224-82-5
Chemical Name
5-Trifluoromethyl-pyridine-2-carbaldehyde
Synonyms
5-(trifluoromethyl)picolinaldehyde;Picolinaldehyde, 5-(trifluoromethyl)-;5-Trifluoromethyl-2-pyridinecarbaldehyde;5-Trifluoromethyl-pyridine-2-carbaldehyde;5-trifluoromethyl pyridine-2-formaldehyde;2-Pyridinecarboxaldehyde, 5-(trifluoromethyl)-;5-(Trifluoromethyl)pyridine-2-carboxaldehyde,95%;5-Trifluoromethyl-pyridine-2-carbaldehyde ISO 9001：2015 REACH;5-Trifluoromethyl-Pyridine-2-Carbaldehyde 5-Trifluoromethyl-Pyridine-2-Carbaldehyde
CBNumber
CB71560087
Molecular Formula
C7H4F3NO
Formula Weight
175.11
MOL File
31224-82-5.mol
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5-Trifluoromethyl-pyridine-2-carbaldehyde Property

Melting point:
31-33℃
Boiling point:
197.5±40.0 °C(Predicted)
Density 
1.369±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
1.30±0.10(Predicted)
Appearance
White to off-white Solid-liquid mixture
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H4F3NO/c8-7(9,10)5-1-2-6(4-12)11-3-5/h1-4H
InChIKey
JJDDVGAESNBKMY-UHFFFAOYSA-N
SMILES
C1(C=O)=NC=C(C(F)(F)F)C=C1
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Safety

HazardClass 
IRRITANT, AIR SENSITIVE
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

SynQuest Laboratories
Product number
4H15-3-15
Product name
5-(Trifluoromethyl)pyridine-2-carbaldehyde
Purity
96%
Packaging
1g
Price
$350
Updated
2021/12/16
Oakwood
Product number
038146
Product name
5-(Trifluoromethyl)-pyridine-2-carboxaldehyde
Packaging
250mg
Price
$82
Updated
2021/12/16
Apolloscientific
Product number
PC201227
Product name
5-(Trifluoromethyl)-2-pyridinecarboxyaldehyde
Purity
95+%
Packaging
250mg
Price
$89
Updated
2021/12/16
Matrix Scientific
Product number
032348
Product name
5-(Trifluoromethyl)pyridine-2-carboxaldehyde
Purity
95%
Packaging
500mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
032348
Product name
5-(Trifluoromethyl)pyridine-2-carboxaldehyde
Purity
95%
Packaging
1g
Price
$195
Updated
2021/12/16
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5-Trifluoromethyl-pyridine-2-carbaldehyde Chemical Properties,Usage,Production

Synthesis

31181-84-7

31224-82-5

General procedure for the synthesis of 5-trifluoromethylpyridine-2-carboxaldehyde from 5-trifluoromethylpyridine-2-methanol: A dichloromethane (10 mL) solution of Example 34B (3.89 g, 22.0 mmol) was added to a dichloromethane (10 mL) solution of Dess-Martin periodinane (1 ,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodioxo heterocyclopentan-3(1H)-one, 10.3 g, 24.2 mmol) in a solution of dichloromethane (73 mL). The reaction mixture was stirred at room temperature for about 20 minutes under nitrogen protection until a solid was formed. The reaction mixture was diluted with 50 mL of dichloromethane and about 30 mL of saturated sodium bicarbonate solution was carefully added to quench the reaction. The undissolved solid was removed by filtration and the filtrate was transferred to a partition funnel. The aqueous phase was extracted with dichloromethane and the combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to 50 mL. The concentrate was purified by passing it through a silica gel column (Analogix? 40 x 150 mm) using 25% to 50% ethyl acetate/hexanes as eluent. 2.86 g (74% yield) of 5-trifluoromethylpyridine-2-carboxaldehyde was finally obtained as a clear oil, which solidified on standing.1H NMR (300 MHz, CDCl3) δ 10.15 (s, 1H), 9.06 (m, 1H), 8.15 (m, 1H), 8.09 (d, J=8.1 Hz, 1H).

References

[1] Patent: US2009/124666, 2009, A1. Location in patent: Page/Page column 26
[2] Patent: US2006/223837, 2006, A1. Location in patent: Page/Page column 35
[3] Patent: US2015/232460, 2015, A1. Location in patent: Paragraph 0478-0480

5-Trifluoromethyl-pyridine-2-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Trifluoromethyl-pyridine-2-carbaldehyde Suppliers

China 115 India 3 United States 9 Global 127
AbaChemScene
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732-484-9848
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sales@chemscene.com
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United States
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Synthonix Inc
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SynQuest Laboratories, Inc.
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Matrix Scientific
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United States
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Beta Pharma, Inc.
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View Lastest Price from 5-Trifluoromethyl-pyridine-2-carbaldehyde manufacturers

PNP Biotech Co. Ltd
Product
5-(Trifluoromethyl)-2-pyridinecarboxyaldehyde 31224-82-5
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-13
Dideu Industries Group Limited
Product
5-Trifluoromethyl-pyridine-2-carbaldehyde 31224-82-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-31
Career Henan Chemical Co
Product
5-Trifluoromethyl-pyridine-2-carbaldehyde 31224-82-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

31224-82-5, 5-Trifluoromethyl-pyridine-2-carbaldehydeRelated Search:

5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 5-TRIFLUOROMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 5-(Trifluoromethyl)indole 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 5-(Trifluoromethyl)-2-pyridinemethanamine 5-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester 3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBOXAMIDE 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](2-THIENYL)METHANONE [3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](PHENYL)METHANONE (4-CHLOROPHENYL)[3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE (2,4-DICHLOROPHENYL)[3-PHENOXY-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](3-METHOXYPHENYL)METHANONE N'2-(2-CHLOROACETYL)-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOHYDRAZIDE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL][3-(TRIFLUOROMETHYL)PHENYL]METHANONE [3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE [3-(4-METHYLPIPERAZINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE (4-CHLOROPHENYL)[3-(4-PHENYLPIPERAZINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE

  • 5-Trifluoromethyl-pyridine-2-carbaldehyde
  • 5-(trifluoromethyl)picolinaldehyde
  • 5-Trifluoromethyl-Pyridine-2-Carbaldehyde 5-Trifluoromethyl-Pyridine-2-Carbaldehyde
  • Picolinaldehyde, 5-(trifluoromethyl)-
  • 5-Trifluoromethyl-2-pyridinecarbaldehyde
  • 2-Pyridinecarboxaldehyde, 5-(trifluoromethyl)-
  • 5-(Trifluoromethyl)pyridine-2-carboxaldehyde,95%
  • 5-Trifluoromethyl-pyridine-2-carbaldehyde ISO 9001：2015 REACH
  • 5-trifluoromethyl pyridine-2-formaldehyde
  • 31224-82-5