ChemicalBook > CAS DataBase List > 5-Hydroxy-2-methoxybenzaldehyde
5-Hydroxy-2-methoxybenzaldehyde
Uses- Product Name
- 5-Hydroxy-2-methoxybenzaldehyde
- CAS No.
- 35431-26-6
- Chemical Name
- 5-Hydroxy-2-methoxybenzaldehyde
- Synonyms
- 2-Methoxy-5-hydroxybenzaldehyde;5-Hydroxy-2-methoxybenzaldehyde;Benzaldehyde, 5-hydroxy-2-methoxy-;5-Hydroxy-2-methoxybenzaldehyde 95+%;5-Hydroxy-2-methoxybenzaldehyde ISO 9001：2015 REACH
- CBNumber
- CB71566665
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 35431-26-6.mol
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5-Hydroxy-2-methoxybenzaldehyde Property
- Melting point:
- 110-115 °C
- Boiling point:
- 309.0±22.0 °C(Predicted)
- Density
- 1.231±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Acetone (Slightly), DMSO (Slightly)
- pka
- 9.73±0.18(Predicted)
- form
- Solid
- color
- Light Brown to Dark Orange
- Stability:
- Air Sensitive
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Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT, AIR SENSITIVE
- HS Code
- 2916399090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- CDS008229
- Product name
- 5-hydroxy-2-methoxybenzaldehyde
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $179
- Updated
- 2025/07/31
TRC
- Product number
- H854260
- Product name
- 5-Hydroxy-2-methoxybenzaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- H854260
- Product name
- 5-Hydroxy-2-methoxybenzaldehyde
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 032441
- Product name
- 5-Hydroxy-2-methoxybenzaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2620-1-59
- Product name
- 5-Hydroxy-2-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $349
- Updated
- 2021/12/16
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5-Hydroxy-2-methoxybenzaldehyde Chemical Properties,Usage,Production
Uses
5-Hydroxy-2-methoxy-benzaldehyde is a phenolic substance that can be used in organic synthesis.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 2437, 1974 DOI: 10.1021/jo00930a032
Synthesis
142677-24-5
35431-26-6
The general procedure for the synthesis of 5-hydroxy-2-methoxybenzaldehyde from 2-methoxy-5-(methoxymethoxy)benzaldehyde was as follows: to a solution of 2-methoxy-5-(methoxymethoxy)benzaldehyde (33.5 g, 0.17 mol, 1 eq.) in tetrahydrofuran (THF, 150 mL) was added 3N hydrochloric acid (HCl, 250 mL, 4.4 eq.). The reaction mixture was stirred at 50 °C for 1 h, subsequently cooled to room temperature and diluted with deionized water (500 mL). The mixture was neutralized to pH 7-8 with solid potassium carbonate (K2CO3). the light yellow solid product was collected by filtration, washed with deionized water and dried to afford 5-hydroxy-2-methoxybenzaldehyde (17.9 g, 74.6% yield) as a light yellow solid. The product was confirmed by NMR hydrogen spectrum (400 MHz, DMSO-d6): δ= 10.31 (s, 1H), 8.03 (s, 1H), 6.89 (s, 1H), 3.80 (s, 3H). Low resolution mass spectrometry (LRMS) showed the molecular ion peak (M+H+) m/z 154.0.
References
[1] Patent: WO2013/102142, 2013, A1. Location in patent: Paragraph 0193
[2] Patent: WO2013/102142, 2013, A1. Location in patent: Paragraph 0172
5-Hydroxy-2-methoxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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