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Dibutyl phthalate

Product Name
Dibutyl phthalate
CAS No.
84-74-2
Chemical Name
Dibutyl phthalate
Synonyms
DBP;Bufa;Elaol;px104;NLA-10;PX 104;DBP(R);NSC 6370;XW-ZS-01;hatcoldbp
CBNumber
CB7161937
Molecular Formula
C16H22O4
Formula Weight
278.34
MOL File
84-74-2.mol
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Dibutyl phthalate Property

Melting point:
-35 °C (lit.)
Boiling point:
340 °C (lit.)
Density 
1.043 g/mL at 25 °C (lit.)
vapor density 
9.6 (vs air)
vapor pressure 
1 mm Hg ( 147 °C)
refractive index 
n20/D 1.492(lit.)
Flash point:
340 °F
storage temp. 
2-8°C
solubility 
Very soluble in alcohol, ether, acetone, benzene
form 
Liquid
color 
APHA: ≤10
Specific Gravity
1.049 (20/20℃)
Relative polarity
0.272
explosive limit
0.47%, 236°F
Water Solubility 
Slightly soluble. 0.0013 g/100 mL
FreezingPoint 
-35℃
Merck 
14,3035
BRN 
1914064
Henry's Law Constant
6.3 x 10-5 atm?m3/mol (quoted, Petrasek et al., 1983)
Exposure limits
NIOSH REL: TWA 5 mg/m3, IDLH 4,000 mg/m3; OSHA PEL: TWA 5 mg/m3; ACGIH TLV: TWA 5 mg/m3.
InChIKey
DOIRQSBPFJWKBE-UHFFFAOYSA-N
CAS DataBase Reference
84-74-2(CAS DataBase Reference)
NIST Chemistry Reference
Dibutyl phthalate(84-74-2)
EPA Substance Registry System
Dibutyl phthalate (84-74-2)
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Safety

Hazard Codes 
T,N,F
Risk Statements 
61-50-62-39/23/24/25-23/24/25-11
Safety Statements 
53-45-61-36/37-16
RIDADR 
UN 3082 9/PG 3
WGK Germany 
2
RTECS 
TI0875000
Autoignition Temperature
756 °F
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29173100
Hazardous Substances Data
84-74-2(Hazardous Substances Data)
Toxicity
Acute oral LD50 for rats 8,000 mg/kg (RTECS, 1985).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H317May cause an allergic skin reaction

H320Causes eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P391Collect spillage. Hazardous to the aquatic environment

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
40066
Product name
Di-n-butyl phthalate solution
Purity
certified reference material, 5000?μg/mL in methanol
Packaging
1 mL
Price
$48.7
Updated
2021/03/22
Sigma-Aldrich
Product number
18281
Product name
Dibutyl phthalate
Purity
certified reference material, TraceCERT
Packaging
50mg
Price
$87.1
Updated
2021/03/22
Sigma-Aldrich
Product number
D1010000
Product name
Dibutyl phthalate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
753939
Product name
DBP
Purity
98% (HPLC)
Packaging
250 mg
Price
$248
Updated
2021/03/22
Sigma-Aldrich
Product number
1187080
Product name
Dibutyl Phthalate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$399
Updated
2021/03/22
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Dibutyl phthalate Chemical Properties,Usage,Production

Description

Dibutyl phthalate is included as an insect repellent in some aerosol sprays used to treat flystrike in sheep. It is colorless oily liquid with a very weak aromatic odor.

Chemical Properties

Dibutyl phthalate occurs as an odorless, oily, colorless, or very slightly yellow-colored, viscous liquid.

Physical properties

Colorless to pale yellow, oily, viscous liquid with a mild, aromatic odor

Uses

Di-n-butyl phthalate has been used as an insect repellant.

Uses

Dibutyl phthalate is used in plasticizers, cosmetics, safety glass, insecticides, printing inks, paper coatings, adhesives, elastomers and explosives; solvent in polysulfide dental impression materials; solvent for perfume oils; perfume fixative; textile lubricating agent; solid rocket propellent; emollient in aerosol antiperspirants; insect repeller; plasticizer in various plastic materials.

Uses

A phthalate metabolite with genotoxic effect.

Uses

Plasticizer; solvent for oil-soluble dyes, insecticides and other organics; antifoam agent; textile fiber lubricant; manometer fluid; fragrance fixative; insect repellent.

Definition

ChEBI: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol.

Production Methods

Dibutyl phthalate is produced from n-butanol and phthalic anhydride in an ester formation reaction.

General Description

Dibutyl phthalate is a colorless oily liquid. Dibutyl phthalate is insoluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since Dibutyl phthalate is a liquid Dibutyl phthalate can easily penetrate the soil and contaminate groundwater and nearby streams. Dibutyl phthalate is combustible though Dibutyl phthalate may take some effort to ignite. Dibutyl phthalate is used in paints and plastics and as a reaction media for chemical reactions.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Dibutyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Avoid contact with strong oxidizing agents and strong bases. Will not polymerize. [USCG, 1999]. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].

Health Hazard

The toxicity of this compound is very low. Inhumans, oral intake of dibutyl phthalate at adose level of 150 mg/kg may cause nausea,vomiting, dizziness, hallucination, distortedvision, lacrimation, and conjunctivitis withprompt recovery. It metabolizes to monobutylester and phthalic acid and is excreted in urine.The inhalation toxicity should be insignificantbecause of its negligible low vapor pressure[<0.1 torr at 20°C (68°F)]. However, expo sure to its mist or aerosol can cause irritationof eyes and mucous membranes
LD50 value, oral (mice): 5300 mg/kg.

Fire Hazard

Combustible.

Pharmaceutical Applications

Dibutyl phthalate is used in pharmaceutical formulations as a plasticizer in film-coatings. It has been evaluated as a pore-forming agent in novel delivery systems.It is also used extensively as a solvent, particularly in cosmetic formulations such as antiperspirants, hair shampoos, and hair sprays. In addition to a number of industrial applications, dibutyl phthalate is used as an insect repellent, although it is not as effective as dimethyl phthalate.

Contact allergens

It is mainly used as a nonreactive epoxy diluent.

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. Mildly toxic by ingestion. Human systemic eye effects by ingestion, hallucinations, dstorted perceptions, nausea or vomiting, and kidney, ureter, or bladder changes. Experimental teratogenic and reproductive effects. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. Violent reaction with Cl2. Incompatible with chlorine. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS, PHTHALIC ACID, and n BUTYL ALCOHOL.

Safety

Dibutyl phthalate is generally regarded as a relatively nontoxic material, although it has occasionally been reported to cause hypersensitivity reactions. It is widely used in topical cosmetic and some oral pharmaceutical formulations.
LD50 (mouse, IV): 0.72g/kg
LD50 (mouse, oral): 5.3g/kg
LD50 (rat, oral): 8.0g/kg
LD50 (rat, IP): 3.05mL/kg

Source

Detected in distilled water-soluble fractions of new and used motor oil at concentrations of 38 to 43 and 15 to 23 μg/L, respectively (Chen et al., 1994). Leaching from flexible plastics in contact with water. Laboratory contaminant.

Environmental Fate

Biological. Under aerobic conditions using a freshwater hydrosol, mono-n-butyl phthalate and phthalic acid were produced. Under anaerobic conditions, phthalic acid was not present (Verschueren, 1983). In anaerobic sludge, di-n-butyl phthalate degraded as follows: monobutyl phthalate to phthalic acid to protocatechuic acid followed by ring cleavage and mineralization (Shelton et al., 1984). Engelhardt et al. (1975) reported that a variety of microorganisms were capable of degrading of di-n-butyl phthalate and suggested the following degradation scheme: di-n-butyl phthalate to mono-n-butyl phthalate to phthalic acid to 3,4-dihydroxybenzoic acid and other unidentified products. Di-n-butyl phthalate was degraded to benzoic acid by tomato cell suspension cultures (Lycopericon lycopersicum) (Pogány et al., 1990).
In a static-culture-flask screening test, di-n-butyl phthalate showed significant biodegradation with rapid adaptation. The ester (5 and 10 mg/L) was statically incubated in the dark at 25°C with yeast extract and settled domestic wastewater inoculum. After 7 days, 100% biodegradation was achieved (Tabak et al., 1981).
Soil. Under aerobic conditions using a fresh-water hydrosol, mono-n-butyl phthalate and phthalic acid were produced. Under anaerobic conditions, however, phthalic acid was not formed (Verschueren, 1983).
Photolytic. An aqueous solution containing titanium dioxide and subjected to UV radiation (l >290 nm) produced hydroxyphthalates and dihydroxyphthalates as intermediates (Hustert and Moza, 1988).
Chemical/Physical. Pyrolysis of di-n-butyl phthalate in the presence of polyvinyl chloride at 600°C gave the following compounds: indene, methylindene, naphthalene, 1- methylnaphthalene, 2-methylnaphthalene, biphenyl, dimethylnaphthalene, acenaphthene, fluorene, methylacenaphthene, methylfluorene and six unidentified compounds (Bove and Dalven, 1984).
Under alkaline conditions, di-n-butyl phthalate will initially hydrolyze to n-butyl hydrogen phthalate and n-butanol. The monoester will undergo further hydrolysis forming o-phthalic acid and n-butanol (Kollig, 1993).

storage

Dibutyl phthalate should be stored in a well-closed container in a cool, dry, location. Containers may be hazardous when empty since they can contain product residues such as vapors and liquids.

Purification Methods

Wash DBP with H2O (to free it from alcohol), then dilute NaOH (to remove any butyl hydrogen phthalate or acid), aqueous NaHCO3 (charcoal), then distilled water. Dry it (CaCl2), distil it at 10torr or less, and store it in a desiccator over P2O5. [Beilstein 9 II 586, 9 III 4102, 9 IV 3175.]

Toxicity evaluation

Acute oral LD50 for rats: >6,000 mg/kg

Incompatibilities

Dibutyl phthalate reacts violently with chlorine. It also reacts with oxidizing agents, acids, bases, and nitrates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, delayed action, enteric coated, and controlled release tablets). Included in nonparenteral medicines licensed in the UK (oral capsules, tablets, granules; topical creams and solutions).

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View Lastest Price from Dibutyl phthalate manufacturers

Hebei Dongdu Import and Export Co. LTD
Product
Dibutyl phthalate;DBP 84-74-2
Price
US $1.60/Kg/Drum
Min. Order
5T
Purity
98%;99%;99.5%
Supply Ability
1000tons/month
Release date
2020-12-10
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dibutyl phthalate (DBP) 84-74-2
Price
US $0.00/Kg/Drum
Min. Order
200KG
Purity
99%min
Supply Ability
500tons/month
Release date
2021-06-03
Hebei Crovell Biotech Co Ltd
Product
Dioctyl Phthalate 84-74-2
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2021-07-13

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