ChemicalBook > CAS DataBase List > Cloxacillin

Cloxacillin

Product Name: Cloxacillin
CAS No.: 61-72-3
Chemical Name: Cloxacillin
Synonyms: Syntarpen;MCIPC;brl1621;CLOXACILLIN;methocillins;Cloxacillin 13C4;Cloxacilline-13c4;Cloxacillin Impurity;Orbenin Extra Dry Cow;CLOXACILLIN USP/EP/BP
CBNumber: CB7163623
Molecular Formula: C19H18ClN3O5S
Formula Weight: 435.88
MOL File: 61-72-3.mol

Less

Cloxacillin Property

Boiling point:: 689.7±55.0 °C(Predicted)
Density: 1.2954 (rough estimate)
refractive index: 1.6100 (estimate)
pka: pKa 2.70±0.07(H2O t=35.0 c=0.0025) (Uncertain)
InChIKey: LQOLIRLGBULYKD-JKIFEVAISA-N
SMILES: N12[C@@]([H])([C@H](NC(C3=C(C)ON=C3C3=CC=CC=C3Cl)=O)C1=O)SC(C)(C)[C@@H]2C(O)=O

Less

Safety

Hazardous Substances Data: 61-72-3(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

AHH

Product number: API-1040
Product name: Cloxacillin
Purity: 98%
Packaging: 25g
Price: $340
Updated: 2021/12/16

Less

Cloxacillin Chemical Properties,Usage,Production

Description

Cloxacillin induced contact dermatitis in a pharmaceutical factory worker with positive reactions to ampicillin but not to penicillin. The chemical formula of this is 3-o-chlorophenyl-5-methyl-4-isoxazolyl penicillin (Knudsen et al., 1962); this differs from oxacillin only by an additional chlorine atom.

Originator

Orbenin,Beecham,UK,1962

Uses

Cloxacillin is a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. It is used to treat a wide variety of bacterial infections.

Definition

ChEBI: Cloxacillin is a semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6. It has a role as an antibacterial agent and an antibacterial drug. It is a semisynthetic derivative, a penicillin allergen and a penicillin. It is functionally related to an oxacillin. It is a conjugate acid of a cloxacillin(1-).

Manufacturing Process

The reaction between 6-aminopenicillanic acid (6.5 g) and 3-o-chlorophenyl-5- methylisoxazole4-carbonyl chloride (7.66 g) gave the sodium salt of 3-o-chlorophenyl-5-methyl-4-isoxazolylpenicillin（Cloxacillin） (9.98 g) as a pale yellow solid. Colorimetric assay with hydroxylamine against a benzylpenicillin standard indicated a purity of 68%.The 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid, from which the acid chloride was prepared, was obtained by hydrolysis of the ester product of the reaction between o-chlorobenzohydroxamic chloride and ethyl acetoacetate in methanolic sodium methoxide. Reaction with thionyl chloride gave the starting material.

brand name

Allypropymal;Alurate sodium;Aprozal;Isonal;Nervisal;Numal;Somnipron.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Ampicillin and cloxacillin are listed separately in the WHO Model List of Essential Drugs.

Contact allergens

Cloxacillin is a semisynthetic penicillin close to oxacillin. It induced contact dermatitis in a pharmaceutical factory worker with positive reactions to ampicillin, but not to penicillin. In cutaneous drug reactions such as acute generalized exanthematous pustulosis due to amoxicillin, cross-reactivity is frequent to cloxacillin (personal observations).

Side effects

Common side effects include Upset stomach, nausea, vomiting, diarrhea, gas, and mouth sores may occur.

Purification Methods

Purify mandelic acid by Soxhlet extraction with *C6H6 (about 6mL/g) and allow the extract to crystallise. It can also be recrystallised from CHCl3. The S-benzylisothiuronium salt has m 169o (166o) (from H2O). Dry it at room temperature under vacuum. [Beilstein 10 IV 565.]

Cloxacillin Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Cloxacillin Suppliers

China 63 Germany 1 India 5 United Kingdom 4 United States 8 Global 81

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

PI & PI BIOTECH INC.

Tel: +86-13602409664 +86-17788709170
Fax: 020-81716319
Email: Sales@pipitech.com
Country: China
ProdList: 2649
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4181
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7924
Advantage: 58

Hebei Chuanghai Biotechnology Co,.LTD

Tel: +86-13131129325
Fax: 86-0311-66562153
Email: sales1@chuanghaibio.com
Country: China
ProdList: 5249
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 8025
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Hebei Chuanghai Biotechnology Co., Ltd

Tel: +8615350571055
Fax: whatapp+8619930503282
Email: Sibel@chuanghaibio.com
Country: China
ProdList: 8768
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 18679456698
Email: mingxinzhu@huidabiotech.com
Country: China
ProdList: 2975
Advantage: 58

Hubei Xinyang Medical Technology Co., Ltd

Tel: 15347293736
Fax: QQ：2853117752
Email: 2853117764@yongstandards.com
Country: China
ProdList: 9997
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3005
Advantage: 58

Heyuan broad spectrum Biotechnology Co., Ltd

Tel: 0762-3393039 18023108599
Email: 2853058244@qq.com
Country: China
ProdList: 991
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Guangzhou Longying Biotechnology Co., Ltd.

Tel: 15975567350
Fax: QQ：632377473
Email: loninbio@sohu.com
Country: China
ProdList: 498
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: +86-0755-66853366 +86-13670046396
Email: export03@qcsrm.com
Country: China
ProdList: 24342
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-0571-89903882 15990081639
Email: sunshixuan@huidabiotech.com
Country: China
ProdList: 3705
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2742
Advantage: 58

Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 9119
Advantage: 58

Zhejiang Jiaguo Biotechnology Co., Ltd

Tel: 0576-057687838881 13968486607
Email: shxc7755@163.com
Country: China
ProdList: 157
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd

Tel: 020-18102736 18102736234
Email: LK@zlstandards.com
Country: China
ProdList: 8206
Advantage: 58

Hubei Moco Chemical Co., Ltd.

Tel: 18627753421; 18627756402
Fax: QQ：3001051413
Email: 3001051413@qq.com
Country: China
ProdList: 20319
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: 2853283383@qq.com
Country: China
ProdList: 11421
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

Beijing Putian Tongchuang Biotechnology Co., Ltd.

Tel: 18201332838
Email: 3032079623@qq.com
Country: China
ProdList: 6695
Advantage: 58

Shanghai Titan Scientific Co.,Ltd

Tel: 16621234537
Email: chenyj@titansci.com
Country: China
ProdList: 10000
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 0714-3299675 13092790750
Email: 3003355938@qq.com
Country: China
ProdList: 9978
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21612
Advantage: 55

Shaanxi Xianhe Biotech Co., Ltd

Tel: +86-17709210191; +8617709210191
Email: Jerry@xhobio.com
Country: China
ProdList: 883
Advantage: 58

Moxin Chemicals

Tel: +86-17320513646 +8617320513646
Email: anna@molcoo.com
Country: China
ProdList: 10000
Advantage: 58

Hebei Zhuanglai Chemical Trading Co Ltd

Tel: +86-16264648883
Email: niki@zlchemi.com
Country: China
ProdList: 7245
Advantage: 58

Guangzhou Tosun Pharmaceutical Limited

Tel: +86-18124244216 +86-18124244216
Email: info@upharm.cn
Country: China
ProdList: 998
Advantage: 58

China National Standard Pharmaceutical Corporation Limited

Tel: +8615391658522
Email: overseasales@yongstandards.com
Country: China
ProdList: 11922
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Shanghai Xiyuan Biotechnology Co., Ltd

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6934
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Yubai Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: rongbai_sh021@163.com
Country: CHINA
ProdList: 6722
Advantage: 58

Shanghai Lianmai Biological Engineering Co., Ltd.

Tel: --
Fax: --
Email: shlmai@163.com
Country: CHINA
ProdList: 6055
Advantage: 58

Qiyi Biotechnology (Shanghai) Co., Ltd.

Tel: --
Fax: --
Email: qiyibio@163.com
Country: CHINA
ProdList: 6241
Advantage: 58

Shanghai Hao Test Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: prbiological@sohu.com
Country: CHINA
ProdList: 6976
Advantage: 58

Shanghai Yuduo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 3128828699@qq.com
Country: CHINA
ProdList: 6508
Advantage: 58

Less

View Lastest Price from Cloxacillin manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Cloxacillin 61-72-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-23

Hebei Chuanghai Biotechnology Co., Ltd

Product: CLOXACILLIN 61-72-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Cloxacillin 61-72-3
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-05

61-72-3, CloxacillinRelated Search:

Flucloxacillin sodium CLOXACILLIN BENZATHINE,Benzathine cloxacillin Dicloxacillin Sodium cloxacillin monohydrate Flucloxacillin Cloxacillin-13C4 SodiuM Salt Dicloxacillin sodium Cloxacillin CLOXACILLIN NA OXACILLIN Penicillin G Cloxacillin sodium sterile Ampicillin Sodium+Cloxacillin Sodium Cloxacillin acid Cloxacillin Sodium Sterile/oral CLOXACILLIN BENZATHINE USP(CRM STANDARD) Cloxacillin sodium lyophilised ANTI-CLOXACILLIN,ANTI-CLOXACILLIN (INCLUDES BSA CONJUGATE)

4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(3-(o-chlorophenyl)-s-me

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo- (8CI)

6-(3-o-Chlorophenyl-5-methylisoxazol-4-ylamido) penicillanic acid

6-(5-Methyl-3-o-chlorophenylisoxazole-4-carboxamido) penicillanic acid

6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolylcarboxamido]penicillanic acid

Orbenin Extra Dry Cow

Syntarpen

Cloxacillin (base and/or unspecified salts)

(2S,5R,6R)-6-[[[5-Methyl-3-(2-chlorophenyl)-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-1-aza-4-thiabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5β)-6α-[[[3-(2-Chlorophenyl)-5-methylisoxazole-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2β-carboxylic acid

MCIPC

(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-7-keto-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

[3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin

3-dimethyl-7-oxo-thyl-4-isoxazolecarboxamido)-

4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(3-(o-chlorophenyl)-5-me

CLOXACILLIN

6-(((3-(2-chlorophenyl)-5-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicaci

6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-o

6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]penicillanicacid

brl1621

methocillins

methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-,(2s-(2alpha,5alpha,6b

xo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid

CLOXACILLIN USP/EP/BP

Cloxacillin 13C4

CloxacillinQ: What is Cloxacillin Q: What is the CAS Number of Cloxacillin

(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid(cloxacillin),

Cloxacillin Impurity

Oxacillin Impurity 5 (Oxacillin EP Impurity E)

Oxacillin Impurity 22

Cloxacillin 1000 μg/mL in Acetonitrile

Cloxacilline-13c4

61-72-3

60-72-3

C19H18ClN3O5S

C19H16N3ClO5S

C19H18CL1N3O5S1