Isobutyl chloroformate
- Product Name
- Isobutyl chloroformate
- CAS No.
- 543-27-1
- Chemical Name
- Isobutyl chloroformate
- Synonyms
- IBCF;isobutyl carbonochloridate;ISOBUTYL CHLOROCARBONATE;2-Methylpropyl chloroformate;isobutyl chloformate;2-Methylpropyl carbonochloridate;2-methyl-1-propylchlorocarbonate;oroformate;Isobutyl chloroforma;Pramoxine Impurity 9
- CBNumber
- CB7165612
- Molecular Formula
- C5H9ClO2
- Formula Weight
- 136.58
- MOL File
- 543-27-1.mol
Isobutyl chloroformate Property
- Melting point:
- -80°C
- Boiling point:
- 128.8 °C(lit.)
- Density
- 1.053 g/mL at 25 °C(lit.)
- vapor pressure
- 0.33 mm Hg ( 20 °C)
- refractive index
- n20/D 1.407(lit.)
- Flash point:
- 82 °F
- storage temp.
- 2-8°C
- solubility
- benzene: miscible
- form
- Liquid
- color
- Clear
- Water Solubility
- Immiscible with water.
- Sensitive
- Moisture Sensitive
- Merck
- 14,5139
- BRN
- 956590
- Dielectric constant
- 9.2（20℃）
- Stability:
- Moisture Sensitive
- CAS DataBase Reference
- 543-27-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Isobutyl chloroformate(543-27-1)
- EPA Substance Registry System
- Isobutyl chloroformate (543-27-1)
Safety
- Hazard Codes
- T
- Risk Statements
- 10-22-23-34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3390 6.1/PG 1
- WGK Germany
- 2
- F
- 10-19
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- I
- HS Code
- 29159000
- Toxicity
- LD50 orally in Rabbit: 1400 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H331Toxic if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 177989
- Product name
- Isobutyl chloroformate
- Purity
- 98%
- Packaging
- 100g
- Price
- $42.46
- Updated
- 2025/07/31
- Product number
- 8.02358
- Product name
- Isobutyl chloroformate
- Purity
- for synthesis
- Packaging
- 2.5L
- Price
- $542
- Updated
- 2025/07/31
- Product number
- 177989
- Product name
- Isobutyl chloroformate
- Purity
- 98%
- Packaging
- 25g
- Price
- $42.6
- Updated
- 2025/07/31
- Product number
- 8.02358
- Product name
- Isobutyl chloroformate
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $47.8
- Updated
- 2024/03/01
- Product number
- I780085
- Product name
- Isobutyl chloroformate
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
Isobutyl chloroformate Chemical Properties,Usage,Production
Chemical Properties
clear liquid
Chemical Properties
A combustible, colorless to light-colored liquid.
Uses
Isobutyl chloroformate is used as a peptide reagent. It is also used in the preparation of phenethyl-carbamic acid isobutyl ester by reaction with phenethylamine.
General Description
A colorless to light-colored liquid. Insoluble in water and denser than water. Very corrosive to skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Combustible.
Air & Water Reactions
Highly flammable. Insoluble in water. Reacts with moisture in the air to produce highly corrosive and toxic fumes of hydrogen chloride gas. Decomposes exothermically in water.
Reactivity Profile
Isobutyl chloroformate is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Hazard
Flammable. Corrosive.
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
reaction suitability
reaction type: Coupling Reactions
Potential Exposure
This is a high volume chemical with production exceeding 1 million pounds annually in the U.S . No specific use found
Shipping
UN2742 Chloroformates, toxic, corrosive, flammable, n.o.s., Hazard class: 6.1; Labels: 6.1—Poison Inhalation Hazard, 8—Corrosive material; 3—Flammable liquid; Technical Name Required, Potential Inhalation Hazard (Special Provision 5). PG II. UN3390 Toxic by inhalation liquid, corrosive, n.o.s. with an LC50 # 1000 mL/m3 and saturated vapor concentration ≥ 10 LC50, Hazard Class: 6.1; Labels: 6.1—Poisonous materials, 8—Corrosive material, Technical Name Required, Inhalation Hazard Zone B
Purification Methods
It can be dried over CaCl2 and fractionated at atmospheric pressure while keeping moisture out. Its purity can be checked by conversion to the phenyl urethane derivative with PhNCO [Saunders et al. J Am Chem Soc 73 3796 1951.] IR: 1780cm-1 [Thompson & Jameson Spectrochim Acta 13 236 1959, R.se JustusLiebigs Ann Chem 205 227 1880]. [Beilstein 3 IV 26.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, ethers, amines. Forms explosive mixture with air above flash point (27C). Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Decomposes exothermically in water. Reacts with moisture in air to produce highly corrosive and toxic fumes of hydrogen chloride gas
Waste Disposal
Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.
Isobutyl chloroformate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isobutyl chloroformate manufacturers
- Product
- Isobutyl chloroformate 543-27-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-16
- Product
- Isobutyl chloroformate 543-27-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08