ChemicalBook > CAS DataBase List > N-Benzoylaminopurine
N-Benzoylaminopurine
- Product Name
- N-Benzoylaminopurine
- CAS No.
- 4005-49-6
- Chemical Name
- N-Benzoylaminopurine
- Synonyms
- N-BENZOYLADENINE;N6-BENZOYLADENINE;N6-BENZOYLAMINOPURINE;N-BZ-ADE;N-(9H-Purin-6-yL;6-BENZAMIDOPURINE;N4-Benzoyl adenine;N-Benzolaminopurine;6-Benzoylaminopurin;6-benzoyl hydrazine
- CBNumber
- CB7165920
- Molecular Formula
- C12H9N5O
- Formula Weight
- 239.23
- MOL File
- 4005-49-6.mol
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N-Benzoylaminopurine Property
- Melting point:
- 242-244°C
- Density
- 1.494 g/cm3
- storage temp.
- 2-8°C
- Water Solubility
- Insoluble in water
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder to crystal
- pka
- 11.98±0.20(Predicted)
- color
- White to Almost white
- BRN
- 20585
- InChI
- InChI=1S/C12H9N5O/c18-12(8-4-2-1-3-5-8)17-11-9-10(14-6-13-9)15-7-16-11/h1-7H,(H2,13,14,15,16,17,18)
- InChIKey
- QQJXZVKXNSFHRI-UHFFFAOYSA-N
- SMILES
- C(NC1=C2C(=NC=N1)NC=N2)(=O)C1=CC=CC=C1
- CAS DataBase Reference
- 4005-49-6(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- B5258
- Product name
- N6-Benzoyladenine
- Purity
- ≥99%
- Packaging
- 5G
- Price
- $143.2
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- B5258
- Product name
- N6-Benzoyladenine
- Purity
- ≥99%
- Packaging
- 25G
- Price
- $864
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B3344
- Product name
- N6-Benzoyladenine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $117
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B3344
- Product name
- N6-Benzoyladenine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $257
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- L08292
- Product name
- N-Benzoylaminopurine, 99%
- Packaging
- 1g
- Price
- $51.65
- Updated
- 2024/03/01
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N-Benzoylaminopurine Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
N6-Benzoyladenine is used in the organic synthesis of adenine derivative molecules such as bicyclic adenine nucleoside via a condensation reaction between L-threo-pentofuranose derivative 1 and 6-N-benzoyladenine and to produce oxy-peptide nucleic acids.
Definition
ChEBI: 6-Benzamidopurine is a member of purines.
Biochem/physiol Actions
N6-Benzoyladenine comprises of adenine moiety and is a potent inhibitor of bromodomain-containing protein 4 (BRD4). N6-Benzoyladenine modulates tumor necrosis factor α (TNF-α) levels. It elicits cytotoxicity in liver and ileum cancer cells and may serve as a potential candidate agent for cancer chemotherapy.
Synthesis
Benzoyl chloride (1.3 mL, 11 mmol) was added dropwise over 30 min to a stirred suspension of adenine (1.35 g, 10 mmol) in dry pyridine, and stirring was continued at 100 °C for a further 3 h, and the reaction mixture was allowed to stand overnight at room temperature. The reaction was quenched with methanol and the solvents were removed under reduced pressure. The residue was triturated in hot isopropanol and dried in vacuo to give 8 as a white solid: yield 2.15 g (90%). MS (+ESI): m/z 240 [M+H]+; 1H NMR (400 MHz, d-DMSO): δ11.50 (s, 1H), 8.74 (s, 1H), 8.52 (s, 1H), 8.11 (d, 2H, J = 7.2 Hz), 7.66 (t, 1H, J = 7.2 Hz), 7.58 (t, 2H, J = 7.2 Hz).
N-Benzoylaminopurine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Benzoylaminopurine manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- N6-Benzoylaminopurine 4005-49-6
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
- Product
- N-Benzoylaminopurine 4005-49-6
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2021-05-14
Career Henan Chemical Co
- Product
- N-(5H-Purin-6-yl)benzamide 4005-49-6
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-15
4005-49-6, N-BenzoylaminopurineRelated Search:
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