ChemicalBook > CAS DataBase List > (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

Product Name: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
CAS No.: 109838-85-9
Chemical Name: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
Synonyms: (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine;(2R)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine;BISLACTIMETHER;(R)-2-Isopropyl-3;Schollkopf Reagent;(R)-Schollkopf Reagent;SCHOELLKOPF-HARTWIG-REAGENT;(2R)-(-)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISO;2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine;(R)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPYRAZINE
CBNumber: CB7167757
Molecular Formula: C9H16N2O2
Formula Weight: 184.24
MOL File: 109838-85-9.mol

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(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine Property

alpha: -102 º (c=1%, EtOH)
Density: 1.028 g/mL at 20 °C (lit.)
Flash point:: 85 °C
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Chloroform and Ethanol
form: Oil
pka: 3.81±0.60(Predicted)
color: Clear Colourless to Pale Yellow
optical activity: [α]20/D 102±5°, c = 1% in ethanol
BRN: 3542790
Boiling point:: 100-102°C (20 hPa)
Stability:: Moisture Sensitive
InChI: InChI=1S/C9H16N2O2/c1-6(2)8-9(13-4)10-5-7(11-8)12-3/h6,8H,5H2,1-4H3/t8-/m1/s1
InChIKey: FCFWEOGTZZPCTO-MRVPVSSYSA-N
SMILES: [C@H]1(C(C)C)N=C(OC)CN=C1OC
CAS DataBase Reference: 109838-85-9(CAS DataBase Reference)

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Safety

Safety Statements: 23-24/25
RIDADR: NA 1993 / PGIII
WGK Germany: 3
F: 10
HS Code: 2933 99 80

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H227Combustible liquid
Precautionary statements: P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 37286
Product name: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
Purity: ≥97.0% (GC)
Packaging: 1ml
Price: $178
Updated: 2025/07/31

Sigma-Aldrich

Product number: 37286
Product name: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
Purity: ≥97.0% (GC)
Packaging: 5ml
Price: $572
Updated: 2025/07/31

TCI Chemical

Product number: D3256
Product name: (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine
Purity: min. 95.0 %
Packaging: 200MG
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: D3256
Product name: (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine
Purity: min. 95.0 %
Packaging: 1G
Price: $252
Updated: 2025/07/31

Chem-Impex

Product number: 41516
Product name: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine,97%(GC)
Purity: 97%(GC)
Packaging: 5ML
Price: $570.08
Updated: 2021/12/16

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(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

(R)-3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazineChiral auxiliary for the synthesis of α-amino acids. It is an inhibitor with antitumor activity.

Synthesis

420-37-1

143673-66-9

109838-85-9

Step A: Preparation of (R)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine: To a 2L round bottom flask was added (R)-3-isopropylpiperazine-2,5-dione (20.7 g, 133 mmol), trimethine oxonium tetrafluoroborate (49.0 g, 331 mmol), and dichloromethane (500 mL). The reaction mixture was stirred vigorously at room temperature and protected by nitrogen.After 18 h, the reaction mixture changed to a clarified solution and formed a very viscous yellow oil at the bottom of the flask. Trimethyloxonium tetrafluoroborate (19.6 g, 133 mmol) was added additionally and stirring was continued at room temperature.After 23 h, the reaction mixture was cooled in an ice bath and 200 g of ice and 100 mL of concentrated ammonium hydroxide solution (28%) were added slowly. Stirring was continued in the ice bath for 1 hr. The organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane (2 x 50 mL). The organic layers were combined, washed sequentially with saturated sodium bicarbonate solution (2 x 100 mL) and brine (100 mL), dried with anhydrous potassium carbonate, filtered through a pad of diatomaceous earth, and concentrated under reduced pressure to give 25.9 g of light brown oil. The crude product was purified by column chromatography (eluent: ether/pentane=1:4) to afford 17.464 g of the target compound (R)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine as a colorless oil in 71.5% yield.1H NMR (400 MHz, CDCl3) δ 4.08-3.94 (m, 3H), 2.95 (s, 3H) , 2.87 (s, 3H), 2.30-2.18 (m, 1H), 1.04 (d, J=7.03Hz, 3H), 0.76 (d, J=6.64Hz, 3H).

References

[1] Organic Process Research and Development, 2005, vol. 9, # 2, p. 185 - 187
[2] Patent: US2006/264431, 2006, A1. Location in patent: Page/Page column 20-21
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995, # 2, p. 157 - 166

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine 109838-85-9
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Shaanxi Dideu Medichem Co. Ltd

Product: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine 109838-85-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-28

Career Henan Chemical Co

Product: (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine 109838-85-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100KG
Release date: 2019-08-29

109838-85-9, (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazineRelated Search:

ISOPROPYL LAURATE Isopropyl alcohol Diphenyldimethoxysilane Phenazine methosulfate Glipizide 1,1-Dimethoxyethane Dimethyldimethoxysilane 3-Chloropropyltrimethoxysilane 3-Mercaptopropyltriethoxysilane Trimethoxypropylsilane (2S)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine Dimethoxymethane Ammonium dihydrogen phosphate 2-ISOPROPYLPYRAZINE (R)-2,5-Dihydro-3,6-diethoxy-2-isopropylpyrazine (R)-(-)-2-Amino-3-methyl-1-butanol (2R,5SR)-(-)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-methylpyrazine (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

(R)-2,5-DIMETHOXY-3-ISOPROPYL-3,6-DIHYDROPYRAZINE

(2R)-3,6-diMethoxy-2-(propan-2-yl)-2,5-dihydropyrazine

(2R)-(-)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISO

(R)-3-Isopropyl-2,5-diMethoxy-3,6-dihydropyrazine, 98%

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine,99%e.e.

(2R)-(-)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine for synthesis

(R)-2-Isopropyl-3

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine >=97.0% (GC)

Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-, (R)-

(R)-2-Isopropyl-3,6-diMethoxy-2,5-dihydropyrazine (85% Purity)

(R)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPYRAZINE

SCHOELLKOPF-HARTWIG-REAGENT

BISLACTIMETHER

(2R)-(-)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPYRAZINE

2R-(-)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazin

Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-, (2R)- (9CI)

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

(2R)-3,6-DIMETHOXY-2-(1-METHYLETHYL)-2,5-DIHYDROPYRAZINE

(2R)-(-)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPYRAZINE, 98+%

(R)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPIPERAZINE

zR{-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

(-)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

(2R)-2,5-Dihydro-3,6-dimethoxy-2-(1-methylethyl)pyrazine

(R)-Schollkopf Reagent

2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

(2R)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

(2R)-(-)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine (aka (R )-Schollkopf reagent)

(3R)-2,5-DiMethoxy-3-(Methylethyl)-3,6-dihydropyrazine

Pyrazine, 2,5-dihydro-3,6-diMethoxy-2-(1-Methylethyl)-, (2R)-

(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (&gt

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine ISO 9001：2015 REACH

Schollkopf Reagent

(<i>R</i>)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine 94%

109838-85-9

Asymmetric Synthesis

Chiral Building Blocks

Pyrazines

Heterocyclic Building Blocks

Heterocycles

Inhibitors

pharmacetical

PIPERIDINE

Auxiliaries,Catalysts