(R)-(-)-2-Amino-3-methyl-1-butanol
- Product Name
- (R)-(-)-2-Amino-3-methyl-1-butanol
- CAS No.
- 4276-09-9
- Chemical Name
- (R)-(-)-2-Amino-3-methyl-1-butanol
- Synonyms
- D-Val-ol;D-VALINOL;D-VALINAL;R-VALINOL;H-D-VAL-OL;(-)-D-VALINOL;D-(-)-VALINOL;D-Valinol, 97%;D-Valinol,99%e.e.;D-(-)-VALINOL 98%
- CBNumber
- CB2173409
- Molecular Formula
- C5H13NO
- Formula Weight
- 103.16
- MOL File
- 4276-09-9.mol
(R)-(-)-2-Amino-3-methyl-1-butanol Property
- Melting point:
- 35-36 °C(lit.)
- Boiling point:
- 189-190 °C(lit.)
- alpha
- -16.5 º (c=10, EtOH)
- Density
- 0.931 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.455
- Flash point:
- 194 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 12.82±0.10(Predicted)
- form
- Low Melting Crystals or Crystalline Mass
- color
- White to light yellow
- optical activity
- [α]20/D 16°, c = 10 in ethanol
- Sensitive
- Air Sensitive
- BRN
- 1719138
- InChIKey
- NWYYWIJOWOLJNR-YFKPBYRVSA-N
- CAS DataBase Reference
- 4276-09-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37-36-36/37/38
- WGK Germany
- 3
- F
- 10-34
- HS Code
- 29051990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 284483
- Product name
- (R)-(?)-2-Amino-3-methyl-1-butanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $24.66
- Updated
- 2025/07/31
- Product number
- 284483
- Product name
- (R)-(?)-2-Amino-3-methyl-1-butanol
- Purity
- 98%
- Packaging
- 5g
- Price
- $77.6
- Updated
- 2025/07/31
- Product number
- V0077
- Product name
- D-Valinol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- V0077
- Product name
- D-Valinol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- 237271
- Product name
- D-Valinol
- Packaging
- 1g
- Price
- $156
- Updated
- 2021/12/16
(R)-(-)-2-Amino-3-methyl-1-butanol Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
D-Valinol is used as a reagent in the synthesis of the HIV type 1 integrase inhibitor Elvitegravir (E509000). D-Valinol is also used in the preparation of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer''s disease.
Synthesis
7146-15-8
4276-09-9
19943-14-7
General procedure for the synthesis of D-valinol and compounds (CAS:19943-14-7) from D-valine methyl ester hydrochloride: Hydrogenation of R-phenylglycine methyl ester was carried out in a 0.5 L stainless steel electrolyzer with stirring at 500 rpm to test the catalyst activity. First, 1 g of catalyst (20-40 mesh) was loaded into the reactor and subsequently purged five times with H2 to remove air. The catalyst was reduced at 1 MPa H2 pressure and 250 °C for 4 hours. After the autoclave was cooled to room temperature in H2 atmosphere, 1.5 g of R-phenylglycine methyl ester (R-p-m) diluted by 150 mL of ethanol (R-p-m/Cat = 1.5, w/w) was added. The reaction conditions were set at 5 MPa H2 pressure and 80 °C temperature for 10 hours. Upon completion of the reaction, the autoclave was cooled to room temperature in H2 atmosphere, followed by separation of the solid catalyst by centrifugation. The product was purified by silica gel column chromatography using ethyl acetate/methanol (3/2, v/v) as eluent. Finally, the light yellow powdery product was obtained by rotary evaporation. The analysis of the reactants and products was carried out using a high performance liquid chromatograph (HPLC, Agilent 1260 Infinity) equipped with a UV detector and an Eclipse XDB-C18 column (150 × 4.6 mm, 5 μm particles), which in turn was used to calculate the conversion of R-phenylglycine methyl ester (X), yield (Y), and chemoselectivity for R-phenylglycine (S), where yield is the liquid chromatographic yield. The enantiomeric excess values (ee values) of the products were determined by HPLC equipped with a UV detector (wavelength 258 nm) and a chiral column (CHIRALPAK AY-H, 250 × 4.6 mm, 5 μm particle size).
References
[1] Catalysis Letters, 2017, vol. 147, # 8, p. 2160 - 2166
(R)-(-)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-(-)-2-Amino-3-methyl-1-butanol manufacturers
- Product
- (R)-(-)-2-Amino-3-methyl-1-butanol 4276-09-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 50kg/month
- Release date
- 2023-01-09
- Product
- (R)-(-)-2-Amino-3-methyl-1-butanol 4276-09-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-29
- Product
- (R)-(-)-2-Amino-3-methyl-1-butanol 4276-09-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11