Tiamulin

ChemicalBook > CAS DataBase List > Tiamulin

Product Name: Tiamulin
CAS No.: 55297-95-5
Chemical Name: Tiamulin
Synonyms: TIAMILIN;tiamulina;TiaMulin fuMerate API;(3aS,4R,5S,6S,8R,9R,9aR,10R)-Decahydro-8-[[2-(diethylamino)ethyl]thio]acetyloxy-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1-one;C12065;sq14055;tiavetp;iamulin;TIAMULIN;Tiamutin
CBNumber: CB7171536
Molecular Formula: C28H47NO4S
Formula Weight: 493.74
MOL File: 55297-95-5.mol

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Tiamulin Property

Melting point:: 147.5°C
Boiling point:: 563.0±50.0 °C(Predicted)
Density: 1.0160 (rough estimate)
refractive index: 1.6550 (estimate)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka: 14.65±0.70(Predicted)
color: Colourless
CAS DataBase Reference: 55297-95-5(CAS DataBase Reference)
EPA Substance Registry System: Tiamulin (55297-95-5)

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Safety

WGK Germany: 2
RTECS: AG9552000
HS Code: 2941906000
Hazardous Substances Data: 55297-95-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34044
Product name: Tiamulin
Purity: VETRANAL?, analytical standard
Packaging: 100MG
Price: $274
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1667355
Product name: Tiamulin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $436
Updated: 2024/03/01

TRC

Product number: T436595
Product name: Tiamulin
Packaging: 100mg
Price: $180
Updated: 2021/12/16

Usbiological

Product number: 286986
Product name: 5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
Packaging: 10g
Price: $333
Updated: 2021/12/16

AK Scientific

Product number: I023
Product name: Tiamulin
Packaging: 100mg
Price: $314
Updated: 2021/12/16

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Tiamulin Chemical Properties,Usage,Production

Uses

Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.

Uses

Tiamulin is a derivative of Pleuromutilin. Antibacterial.

Definition

ChEBI: A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) fo the treatment of swine dysentery caused by Serpulina hyodysenteriae.

General Description

Tiamulin has been developed by that company in collaboration with E.R. Squibb & Sons for use against animal infec tions. Tiamulin is used against dysentery and Mycoplasma infections in sheep, swine, cattle, and chickens.

Safety Profile

Poison by intramuscular and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.

Synthesis

Tiamulin was synthesized by Sandoz Co. in 1973, starting from pleuromutilin produced by Pleurotus mutilus.

Veterinary Drugs and Treatments

Tiamulin is approved for use in swine to treat pneumonia caused by susceptible strains of Haemophilus pleuropneumoniae and swine dysentery caused by Treponema hyodysenteriae. As a feed additive, it is used to cause increased weight gain in swine.

Tiamulin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tiamulin manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Tiamulin 55297-95-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg
Release date: 2024-03-25

Hebei Guanlang Biotechnology Co,.LTD

Product: Tiamulin hyclate 55297-95-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2021-06-25

Hebei Zhanyao Biotechnology Co. Ltd

Product: Tiamulin 55297-95-5
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-04

55297-95-5, TiamulinRelated Search:

Pleuromulin CHLOROPHOSPHONAZO III TIAMULIN FUMARATE VETRANAL, 100 MG,TIAMULIN FUMERATE,TIAMULIN FUMARATE,TIAMULIN HYDROGEN FUMARATE Tylosin Telithromycin Tulathromycin A ISOOCTYL THIOGLYCOLATE CYCLOUNDECANONE 2-Ethylhexyl mercaptoacetate ISOPROPYL THIOGLYCOLATE TIAMULIN FUMERATE,TIAMULIN HYDROGEN FUMARATE TIAMULIN FOR PEAK IDENTIFICATION ACETIC ACID, MERCAPTO-, ISOTRIDECYLESTER THIOGLYCOLIC ACID N-OCTYL ESTER TIAMULIN - REFERENCE SPECTRUM Tiamulin LAURYL THIOGLYCOLATE N-DECYL THIOGLYCOLATE

TIAMILIN

(3aS,4R,5S,6S,8R,9R,9aR,10R)-Decahydro-8-[[2-(diethylamino)ethyl]thio]acetyloxy-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1-one

[[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,10R,9aβ)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester

[[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester

[2-(Diethylamino)ethylthio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester

C12065

Tiamulin (100 mg)

TiaMulin fuMerate API

,10-tetramethyl-1-oxo-3a,9-propano-3ah-cyclopentacycloocten-8-ylester,(3as-(

14-deoxy-14-((2-diethylaminoethyl-thio)-acetoxy)mutiline

4-beta,5-alpha,6-alpha,8-beta,9-beta,10s*))-3a-alph

aceticacid,((2-(diethylamino)ethyl)thio)-,6-ethenyldecahydro-5-hydroxy-4,6,9

sq14055

thiamutilin

tiamulina

tiavetp

TIAMULIN

(1S,2R,3S,4S,6R,7S,14R)-6-[(2-DIETHYLAMINOETHYLTHIO)ACETOXY]-3-HYDROXY-2,4,7,14-TETRAMETHYL-4-VINYLTRICYCLO[5,4,3,01.8]TETRADECAN-9-ONE

5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate

Tiamulin Solution, 1000ppm

Tiamutin

Acetic acid, 2-(diethylamino)ethylthio-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

Tiamulin Solution, 100ppm

Thiamuline

Tiamulin for peak identification CRS

Acetic acid, 2-[[2-(diethylamino)ethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

iamulin

Tiamulin hyclate

TiamulinQ: What is Tiamulin Q: What is the CAS Number of Tiamulin Q: What is the storage condition of Tiamulin

TIANFU-CHEM - Tiamulin

Tiamulin (1667355)

55297-95-5

55297-96-5

55297-98-6

C28H47NO4S