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Tiamulin fumarate

Product Name
Tiamulin fumarate
CAS No.
55297-96-6
Chemical Name
Tiamulin fumarate
Synonyms
TIAMULIN HYDROGEN FUMARATE;Tiamuline Hydrogen Fumarate;DENAGARD;TIAMULIN FUMERATE;((2-(DIETHYLAMINO)ETHYL)THIO)ACETIC ACID 8-ESTER WITH (3AS,4R,5S,6S,8R,9R,9AR,10R)-OCTAHYDRO-5,8-DIHYDROXY-4,6,9,10-TETRAMETHYL-6-VINYL-3A,9-PROPANO-3AH-CYCLOPENTACYCLOOCTEN-1(4H)-ONE FUMARATE;sq22947;STAMULIN;81723hfu;dynamutilin;sandoz81723hfu
CBNumber
CB0294038
Molecular Formula
C32H51NO8S
Formula Weight
609.82
MOL File
55297-96-6.mol
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Tiamulin fumarate Property

Melting point:
147-148°C
Boiling point:
563℃
Flash point:
>110°(230°F)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
color 
White
Water Solubility 
Soluble in water
Merck 
13,9495
InChI
InChI=1/C28H47NO4S.C4H4O4/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28;5-3(6)1-2-4(7)8/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t19-,20+,22-,24+,25+,26-,27?,28?;/s3
InChIKey
YXQXDXAHCSEVSD-IHAONTCTSA-N
SMILES
C(/C(=O)O)=C\C(=O)O.C[C@H]1[C@@H]([C@](C[C@@H](OC(=O)CSCCN(CC)CC)C2([C@H](C)CCC31CCC(=O)[C@]32[H])C)(C)C=C)O |&1:9,10,11,13,27,36,r|
CAS DataBase Reference
55297-96-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN2811 6.1/PG 3
WGK Germany 
3
RTECS 
AG9560000
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2721
Product name
Tiamulin fumarate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 500?mg
Packaging
500MG
Price
$241
Updated
2024/03/01
Sigma-Aldrich
Product number
46959
Product name
Tiamulin fumarate
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$54.4
Updated
2024/03/01
Sigma-Aldrich
Product number
1667290
Product name
Tiamulin fumarate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
J66020
Product name
Tiamulin fumarate
Purity
95%
Packaging
500mg
Price
$274
Updated
2024/03/01
Alfa Aesar
Product number
J66020
Product name
Tiamulin fumarate
Purity
95%
Packaging
100mg
Price
$55.5
Updated
2023/06/20
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Tiamulin fumarate Chemical Properties,Usage,Production

Chemical Properties

White Solid. soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide.

Uses

Tiamulin fumarate is a semisynthetic pleuromutilin antibiotic that binds to the ribosomal peptidyl transferase centre and inhibits protein synthesis. It is a derivative of Pleuromutilin with Antibacterial that targets Gram-positive bacteria as well as a few mycoplasma species.

Application

Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity. The hemi-fumarate provides a stable salt with improved water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action of inhibiting protein synthesis by binding to domain V of 23S rRNA.

Indications

Tiamulin fumarate is mainly used for Mycoplasma suis pneumonia, Haemophilus parasuis, infectious pleuropneumonia and dysentery caused by Treponema swine, and also for chronic respiratory tract of poultry, Mycoplasma pneumonia, infectious rhinitis, Escherichia coli, duck Infectious serositis.

Mode of action

Tiamulin fumarate is a bacteriostatic antibiotic belonging to the pleuromutilin class, which inhibit protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.

Tiamulin fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tiamulin fumarate Suppliers

Shanghai Dingfen Chemical Technology Co., Ltd.
Tel
021-57450129 02157450129
Fax
021-57450128
Email
2789251452@qq.com
Country
China
ProdList
7702
Advantage
58
Shandong Jihao Biotechnology Co., Ltd.
Tel
0531-69958659 15668363232
Email
8598038@qq.com
Country
China
ProdList
39
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2894
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
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View Lastest Price from Tiamulin fumarate manufacturers

Hebei Dangtong Import and export Co LTD
Product
Tiamulin fumarate 55297-96-6
Price
US $30.00-24.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
4000kg
Release date
2023-09-15
Hebei Dangtong Import and export Co LTD
Product
Tiamulin fumarate 55297-96-6
Price
US $23.00-17.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg
Release date
2023-09-15
Hebei Dangtong Import and export Co LTD
Product
Tiamulin fumarate 55297-96-6
Price
US $27.00-10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
300tons
Release date
2023-03-17

55297-96-6, Tiamulin fumarateRelated Search:


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  • C28H47NO4SC4H4O4
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