3-Bromoimidazo[1,2-a]pyrimidine

Uses

Product Name: 3-Bromoimidazo[1,2-a]pyrimidine
CAS No.: 6840-45-5
Chemical Name: 3-Bromoimidazo[1,2-a]pyrimidine
Synonyms: -Bromoimidazo[1,2-a]pyrimidine;3-BROMOIMIDAZO[1,2-A]PYRIMIDINE;Imidazo[1,2-a]pyrimidine, 3-bromo-;3-BROMOIMIDAZOL-(1,2-A)-PYRIMIDINE;3-Bromoimidazo[1,2-a]pyrimidine 98%;3-Bromoimidazo[1,2-a]pyrimidine ISO 9001：2015 REACH
CBNumber: CB7175802
Molecular Formula: C6H4BrN3
Formula Weight: 198.02
MOL File: 6840-45-5.mol

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3-Bromoimidazo[1,2-a]pyrimidine Property

Melting point:: 158-160
Density: 1.89±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 2.55±0.30(Predicted)
color: Light brown
InChI: InChI=1S/C6H4BrN3/c7-5-4-9-6-8-2-1-3-10(5)6/h1-4H
InChIKey: GNHZXUKWLSWKHB-UHFFFAOYSA-N
SMILES: C12=NC=C(Br)N1C=CC=N2
CAS DataBase Reference: 6840-45-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B696335
Product name: 3-Bromoimidazo[1,2-a]pyrimidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696335
Product name: 3-Bromoimidazo[1,2-a]pyrimidine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B696335
Product name: 3-Bromoimidazo[1,2-a]pyrimidine
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-Z4
Product name: 3-Bromoimidazo[1,2-a]pyrimidine
Packaging: 1g
Price: $44
Updated: 2021/12/16

AK Scientific

Product number: Q471
Product name: 3-Bromoimidazo[1,2-a]pyrimidine
Packaging: 1g
Price: $49
Updated: 2021/12/16

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3-Bromoimidazo[1,2-a]pyrimidine Chemical Properties,Usage,Production

Uses

3-Bromoimidozolo[1,2-a]pyrimidine can be used to prepare HPK1 inhibitors.

Synthesis

274-95-3

6840-45-5

Imidazo[1,2-a]pyrimidine (4 g) and sodium acetate (4.3 g) were dissolved in methanol (40 ml) in a 100 ml three-necked round-bottomed flask, followed by cooling the reaction mixture to -10°C. Bromine (5.38 g) was added slowly and dropwise with stirring. Upon completion of the reaction, 1M aqueous sodium sulfide (40 ml) was added to quench the reaction and the mixture was subsequently concentrated under reduced pressure to remove the solvent. Liquid-liquid extraction was carried out via ethyl acetate and water to separate the by-products, and finally the crude product was purified by column chromatography using dichloromethane and methanol as eluents to give 3.2 g of 3-bromoimidazo[1,2-a]pyrimidine.

References

[1] European Journal of Medicinal Chemistry, 1991, vol. 26, # 1, p. 13 - 18
[2] Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 5, p. 1170 - 1176
[3] Patent: KR2017/126059, 2017, A. Location in patent: Paragraph 0069; 0072; 0073; 0078; 0079

3-Bromoimidazo[1,2-a]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromoimidazo[1,2-a]pyrimidine Suppliers

China 118 France 1 Germany 3 Hungary 1 India 1 United Kingdom 10 United States 22 Global 156

Xuchang Fengfei New Materials Technology Co., Ltd

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View Lastest Price from 3-Bromoimidazo[1,2-a]pyrimidine manufacturers

Dideu Industries Group Limited

Product: 3-Bromoimidazo[1,2-a]pyrimidine 6840-45-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Career Henan Chemical Co

Product: 3-Bromoimidazo[1,2-a]pyrimidine 6840-45-5
Price: US $5.50/KG
Min. Order: 1ASSAYS
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-10

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3-BROMOIMIDAZO[1,2-A]PYRIMIDINE

3-BROMOIMIDAZOL-(1,2-A)-PYRIMIDINE

Imidazo[1,2-a]pyrimidine, 3-bromo-

3-Bromoimidazo[1,2-a]pyrimidine ISO 9001：2015 REACH

-Bromoimidazo[1,2-a]pyrimidine

3-Bromoimidazo[1,2-a]pyrimidine 98%

6840-45-5

C6H4BrN3

Fused Ring Systems

Halides

Heterocycle-Pyrimidine series

Fluorobenzene

Pyrimidines