Diprophylline

Product Name: Diprophylline
CAS No.: 479-18-5
Chemical Name: Diprophylline
Synonyms: DYPHYLLINE;DIPHYLLIN;Coronarin;Dihydroxypropyl;Dilor;Teofen;Circain;Neotilina;Neutrafil;Corphyllin
CBNumber: CB7177891
Molecular Formula: C10H14N4O4
Formula Weight: 254.24
MOL File: 479-18-5.mol

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Diprophylline Property

Melting point:: 161-162 °C(lit.)
Boiling point:: 397.46°C (rough estimate)
Density: 1.3036 (rough estimate)
refractive index: 1.6200 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent).
pka: 13.74±0.20(Predicted)
form: Powder
color: White
Water Solubility: 33 g/100 mL (25 ºC)
Merck: 14,3479
BRN: 284563
Stability:: Hygroscopic
LogP: -1.100 (est)
CAS DataBase Reference: 479-18-5(CAS DataBase Reference)
NIST Chemistry Reference: Dyphylline(479-18-5)
EPA Substance Registry System: Dyphylline (479-18-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 36-36/37-26
WGK Germany: 3
RTECS: XH5100000
TSCA: Yes
HS Code: 29395900
Hazardous Substances Data: 479-18-5(Hazardous Substances Data)
Toxicity: LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1231502
Product name: Diprophylline
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $358
Updated: 2024/03/01

Sigma-Aldrich

Product number: D0633
Product name: 7-(2,3-Dihydroxypropyl)theophylline
Packaging: 1kg
Price: $579
Updated: 2023/01/07

Alfa Aesar

Product number: J63167
Product name: Dyphylline
Packaging: 100g
Price: $86.65
Updated: 2024/03/01

Alfa Aesar

Product number: J63167
Product name: Dyphylline
Packaging: 1kg
Price: $367
Updated: 2021/12/16

Cayman Chemical

Product number: 17958
Product name: Dyphylline
Purity: ≥98%
Packaging: 50mg
Price: $62
Updated: 2024/03/01

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Diprophylline Chemical Properties,Usage,Production

Description

Dyphylline is the N-7 dihydroxypropyl derivative of theophylline and is not a theophylline salt. Dyphylline does not get metabolized to theophylline in vivo, and even though it contains 70% theophylline by molecular weight ratio, the equivalent amount to theophylline is not known. Dosing must be accomplished independently by monitoring dyphylline blood levels. Dyphylline has a diminished bronchodilator effect compared to theophylline, but it may have lower and less serious side effects. Dosage forms available are an elixir and tablets.

Description

Dyphylline is a xanthine derivative that acts as an A₁ and A₂ adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects. It also moderately inhibits microsomal prostaglandin E synthase-1 with an IC₅₀ value of 200 μM and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.

Chemical Properties

white to light yellow crystal powder

Originator

Neothylline,Lemmon,US,1948

Uses

PDE inhibitor, bronchodilator, vasodilator

Uses

An adenosine receptor antagonist, phosphodiesterase inhibitor and vasodilator

Definition

ChEBI: An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.

Manufacturing Process

180 grams of theophylline is dissolved in 500 cc of boiling water. To this solution is added 40 grams of sodium hydroxide or 56 grams of potassium hydroxide slowly and with constant stirring.
When solution is complete, 120 grams of 1-chloro-2,3-dihydroxypropane is slowly added. The thus provided mixture is brought to boiling and heating is continued until a temperature of 110°C is reached.
The resultant liquid is evaporated under reduced pressure to remove all traces of water. The resulting syrupy liquid is allowed to stand with occasional stirring until crystallization takes place. The compound is purified by recrystallization from alcohol. The product melts at 155°-157°C.

brand name

Dilor (Savage); Lufyllin (Medpointe); Neothylline (Teva).

Therapeutic Function

Smooth muscle relaxant

Biochem/physiol Actions

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Diprophylline Preparation Products And Raw materials

Raw materials

Propylene glycol Sodium Theophylline(1,3-Dimethyl-2,6-dione-purine-Na)

Preparation Products

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Diprophylline Suppliers

Americas 1 Argentina 1 Belgium 3 Canada 5 China 298 Europe 3 France 1 Germany 6 India 21 Italy 2 Japan 3 Philippines 1 Singapore 1 South Africa 1 Switzerland 3 United Kingdom 14 United States 43 Global 407

Apin Chemicals Limited (UK)

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Maybridge Chemical Co. Ltd.

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NBS Biologicals

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Molekula Limited

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Wessex Fine Chemicals Ltd.

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Melford Laboratories Ltd.

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Long-Range Europe Limited

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CMS Chemicals Limited

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Whyte Chemicals

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Leancare Ltd.

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ProdList: 6446
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CARBONE SCIENTIFIC CO.,LTD

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Eurolabs Limited

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MOLEKULA Ltd.

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Apin Chemicals Ltd.

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ProdList: 6807
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View Lastest Price from Diprophylline manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Diprophylline 479-18-5
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 10tons
Release date: 2024-04-25

shandong perfect biotechnology co.ltd

Product: Diprophylline 479-18-5
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2023-08-09

Hebei Weibang Biotechnology Co., Ltd

Product: Diprophylline 479-18-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

479-18-5, DiprophyllineRelated Search:

N,N-Dimethylaniline Dimethyl ether ETHANE 2-Hydroxypropyl-β-cyclodextrin Hydroxypropyl methyl cellulose PROXYPHYLLINE Poly(dimethylsiloxane) Dimethyl carbonate N,N-Dimethylformamide Hydroxypropyl cellulose Dimethyl fumarate Dichlorodimethylsilane Dacthal 1,3-Dihydroxyacetone Hydroxypropyl acrylate Purine Dimethyl sulfoxide Dimethyl sulfone

7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine

1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-

1h-purine-2,6-dione,7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl

7-(2,3-Dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Circain

circair

component of Dilor g

component of Neothylline-gg

Coronal

Coronarin

Corphyllin

Cor-Theophylline

Dihydroxypropyl theophylline

Dihydroxypropyl theopylin

dihydroxypropyltheophylline

dihydroxypropyltheopylin

Dilor

Diprofillin

Diprofilline

diprophyllinee

Dipropylline

Droxine

Dyflex

Glyfyllin

Glyphyllin

Glyphylline

Hidroxiteofillina

Hiphyllin

Hyphylline

Iphyllin

Liactemin

Neophyl

Neophyllin

neophyllinm

neostenorasan

Neostenovasan

Neothylline

Neotilina

Neo-Vasophylline

Neufil

Neutrafil

Neutrafillina

Neutraphyllin

Neutraphylline

Neutroxantina

propylphyllin

Propyphyllin

Protheophylline

Purifilin

sibephyllin

sibephylline

Silbephyllin

Silbephylline

Solufilin

Solufyllin

Soluphyllin

Synthophylline

Tefilan