ChemicalBook > CAS DataBase List > Diprophylline

Diprophylline

Product Name
Diprophylline
CAS No.
479-18-5
Chemical Name
Diprophylline
Synonyms
DYPHYLLINE;DIPHYLLIN;Coronarin;Dihydroxypropyl;Dilor;Teofen;Circain;Neotilina;Neutrafil;Corphyllin
CBNumber
CB7177891
Molecular Formula
C10H14N4O4
Formula Weight
254.24
MOL File
479-18-5.mol
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Diprophylline Property

Melting point:
161-162 °C(lit.)
Boiling point:
397.46°C (rough estimate)
Density 
1.3036 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent).
pka
13.74±0.20(Predicted)
form 
Powder
color 
White
Water Solubility 
33 g/100 mL (25 ºC)
Merck 
14,3479
BRN 
284563
Stability:
Hygroscopic
LogP
-1.100 (est)
CAS DataBase Reference
479-18-5(CAS DataBase Reference)
NIST Chemistry Reference
Dyphylline(479-18-5)
EPA Substance Registry System
Dyphylline (479-18-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-36/37-26
WGK Germany 
3
RTECS 
XH5100000
TSCA 
Yes
HS Code 
29395900
Hazardous Substances Data
479-18-5(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1231502
Product name
Diprophylline
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$358
Updated
2024/03/01
Sigma-Aldrich
Product number
D0633
Product name
7-(2,3-Dihydroxypropyl)theophylline
Packaging
1kg
Price
$579
Updated
2023/01/07
Alfa Aesar
Product number
J63167
Product name
Dyphylline
Packaging
100g
Price
$86.65
Updated
2024/03/01
Alfa Aesar
Product number
J63167
Product name
Dyphylline
Packaging
1kg
Price
$367
Updated
2021/12/16
Cayman Chemical
Product number
17958
Product name
Dyphylline
Purity
≥98%
Packaging
50mg
Price
$62
Updated
2024/03/01
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Diprophylline Chemical Properties,Usage,Production

Description

Dyphylline is the N-7 dihydroxypropyl derivative of theophylline and is not a theophylline salt. Dyphylline does not get metabolized to theophylline in vivo, and even though it contains 70% theophylline by molecular weight ratio, the equivalent amount to theophylline is not known. Dosing must be accomplished independently by monitoring dyphylline blood levels. Dyphylline has a diminished bronchodilator effect compared to theophylline, but it may have lower and less serious side effects. Dosage forms available are an elixir and tablets.

Description

Dyphylline is a xanthine derivative that acts as an A1 and A2 adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects. It also moderately inhibits microsomal prostaglandin E synthase-1 with an IC50 value of 200 μM and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.

Chemical Properties

white to light yellow crystal powder

Originator

Neothylline,Lemmon,US,1948

Uses

PDE inhibitor, bronchodilator, vasodilator

Uses

An adenosine receptor antagonist, phosphodiesterase inhibitor and vasodilator

Definition

ChEBI: An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.

Manufacturing Process

180 grams of theophylline is dissolved in 500 cc of boiling water. To this solution is added 40 grams of sodium hydroxide or 56 grams of potassium hydroxide slowly and with constant stirring.
When solution is complete, 120 grams of 1-chloro-2,3-dihydroxypropane is slowly added. The thus provided mixture is brought to boiling and heating is continued until a temperature of 110°C is reached.
The resultant liquid is evaporated under reduced pressure to remove all traces of water. The resulting syrupy liquid is allowed to stand with occasional stirring until crystallization takes place. The compound is purified by recrystallization from alcohol. The product melts at 155°-157°C.

brand name

Dilor (Savage); Lufyllin (Medpointe); Neothylline (Teva).

Therapeutic Function

Smooth muscle relaxant

Biochem/physiol Actions

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Diprophylline Preparation Products And Raw materials

Raw materials

Propylene glycol Sodium Theophylline(1,3-Dimethyl-2,6-dione-purine-Na)

Preparation Products

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Diprophylline Suppliers

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View Lastest Price from Diprophylline manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.
Product
Diprophylline 479-18-5
Price
US $0.00/kg
Min. Order
25kg
Purity
99.0%
Supply Ability
10tons
Release date
2024-04-25
Hebei Mujin Biotechnology Co.,Ltd
Product
Diprophylline 479-18-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-30
shandong perfect biotechnology co.ltd
Product
Diprophylline 479-18-5
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
100kg
Release date
2023-08-09

479-18-5, DiprophyllineRelated Search:

N,N-Dimethylaniline Dimethyl ether ETHANE 2-Hydroxypropyl-β-cyclodextrin Hydroxypropyl methyl cellulose PROXYPHYLLINE Poly(dimethylsiloxane) Dimethyl carbonate N,N-Dimethylformamide Hydroxypropyl cellulose Dimethyl fumarate Dichlorodimethylsilane Dacthal 1,3-Dihydroxyacetone Hydroxypropyl acrylate Purine Dimethyl sulfoxide Dimethyl sulfone

  • 7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine
  • 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-
  • 1h-purine-2,6-dione,7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl
  • 7-(2,3-Dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • Circain
  • circair
  • component of Dilor g
  • component of Neothylline-gg
  • Coronal
  • Coronarin
  • Corphyllin
  • Cor-Theophylline
  • Dihydroxypropyl theophylline
  • Dihydroxypropyl theopylin
  • dihydroxypropyltheophylline
  • dihydroxypropyltheopylin
  • Dilor
  • Diprofillin
  • Diprofilline
  • diprophyllinee
  • Dipropylline
  • Droxine
  • Dyflex
  • Glyfyllin
  • Glyphyllin
  • Glyphylline
  • Hidroxiteofillina
  • Hiphyllin
  • Hyphylline
  • Iphyllin
  • Liactemin
  • Neophyl
  • Neophyllin
  • neophyllinm
  • neostenorasan
  • Neostenovasan
  • Neothylline
  • Neotilina
  • Neo-Vasophylline
  • Neufil
  • Neutrafil
  • Neutrafillina
  • Neutraphyllin
  • Neutraphylline
  • Neutroxantina
  • propylphyllin
  • Propyphyllin
  • Protheophylline
  • Purifilin
  • sibephyllin
  • sibephylline
  • Silbephyllin
  • Silbephylline
  • Solufilin
  • Solufyllin
  • Soluphyllin
  • Synthophylline
  • Tefilan