4-Fluorocinnamic acid

Product Name: 4-Fluorocinnamic acid
CAS No.: 459-32-5
Chemical Name: 4-Fluorocinnamic acid
Synonyms: AKOS 92741;(E)-3-(4-FL;AKOS BB/0035;4-fluoride acid;AKOS BBS-00006474;4-Fluorocinmic acid;TIMTEC-BB SBB005718;RARECHEM BK HC T330;4-FUOROCINNAMIC ACID;OTAVA-BB BB0103940052
CBNumber: CB7178186
Molecular Formula: C9H7FO2
Formula Weight: 166.15
MOL File: 459-32-5.mol

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4-Fluorocinnamic acid Property

Melting point:: 209-210 °C (lit.)
Boiling point:: 290°C (rough estimate)
Density: 1.2247 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 4.43±0.10(Predicted)
form: Crystalline Solid
color: White to off-white
BRN: 2613441
InChI: InChI=1S/C9H7FO2/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6H,(H,11,12)
InChIKey: ISMMYAZSUSYVQG-UHFFFAOYSA-N
SMILES: C(O)(=O)C=CC1=CC=C(F)C=C1
CAS DataBase Reference: 459-32-5(CAS DataBase Reference)
NIST Chemistry Reference: 4-Fluorocinnamic acid(459-32-5)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34
Safety Statements: 37/39-26-45-36/37/39-27-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 222720
Product name: 4-Fluorocinnamic acid
Purity: 99%
Packaging: 5g
Price: $48.45
Updated: 2025/07/31

TCI Chemical

Product number: F0244
Product name: 4-Fluorocinnamic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: F0244
Product name: 4-Fluorocinnamic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $90
Updated: 2025/07/31

TRC

Product number: F588620
Product name: 4-Fluorocinnamic Acid
Packaging: 25g
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 004178
Product name: 4-Fluorocinnamic acid
Purity: 98%
Packaging: 25g
Price: $14
Updated: 2021/12/16

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4-Fluorocinnamic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorocinnamic acid was used in growth medium for the Arthrobacter sp. strain G1.

Definition

ChEBI: 4-Fluorocinnamic acid is a member of cinnamic acids.

General Description

The shock loading of 4-fluorocinnamic acid (4-FCA) was treated using a rotating biological contactor (RBC).

Synthesis

352-34-1

79-10-7

459-32-5

GENERAL METHODS: Lithium tert-butanol or potassium tert-butanol (3.0 mmol), water (2.0 mL), and acrylic acid (1.2 mmol) were sequentially added to a Schlenk reaction tube under nitrogen atmosphere and stirred for 10 min at room temperature. Subsequently, p-fluoroiodobenzene (1.0 mmol) and palladium(II)-imidazole complex 1 (1.0 mol%) were added. The reaction mixture was stirred at 100 °C for 12 hours. After completion of the reaction, it was cooled to room temperature, acidified to pH 1 with 4 M hydrochloric acid and subsequently extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by rapid chromatography on a silica gel column to give pure p-fluorocinnamic acid.

References

[1] Journal of Chemical Research, 2013, vol. 37, # 5, p. 294 - 297
[2] Synlett, 2006, # 18, p. 2959 - 2964
[3] Journal of Organic Chemistry, 2004, vol. 69, # 23, p. 8105 - 8107
[4] Reactive and Functional Polymers, 2011, vol. 71, # 7, p. 756 - 765

4-Fluorocinnamic acid Preparation Products And Raw materials

Raw materials

Piperidine 4-Fluorobenzaldehyde Pyridine Malonic acid

Preparation Products

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4-Fluorocinnamic acid Suppliers

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View Lastest Price from 4-Fluorocinnamic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Fluorocinnamic acid 459-32-5
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2024-11-18

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4-Fluorocinnamic acid 459-32-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-16

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Fluorocinnamic acid 459-32-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

459-32-5, 4-Fluorocinnamic acidRelated Search:

N-BUTYL CINNAMATE Cinnamic acid 4-Hydroxycinnamic acid Ethyl cinnamate alpha-Methylcinnamic acid Methyl cinnamate trans-Cinnamic acid Xemilofiban D-PROPARGYLGLYCINE (S)-N-BOC-Propargylglycine L-Propargylglycine HCL (R)-N-BOC-Propargylglycine 3-Fluorocinnamicacid 2-BROMO-5-FLUOROCINNAMIC ACID 3-CHLORO-4-FLUOROCINNAMIC ACID 4-Chloro-2-fluorocinnamic acid 98%,4-CHLORO-2-FLUOROCINNAMIC ACID (E)-p-fluorocinnamic acid,P-FLUOROCINNAMIC ACID,TRANS-4-FLUOROCINNAMIC ACID FMOC-L-PROPARGYLGLYCINE

2-Propenoic acid, 3-(4-fluorophenyl)-

RARECHEM BK HC T330

OTAVA-BB BB0103940052

(2E)-3-(4-fluorophenyl)prop-2-enoic acid

3-(4-Fluorophenyl)acrylic acid, 3-(4-Fluorophenyl)prop-2-enoic acid

4-Fluorocinmic acid

(E)-3-(4-Fluorophenyl)acrylic Acid, 97+%

(E)-3-(4-fluorophenyl)-2-propenoate

P-FLUOROCINNAMIC ACID

TIMTEC-BB SBB005718

TRANS-4-FLUOROCINNAMIC ACID

(2E)-3-(4-FLUOROPHENYL)-2-PROPENOIC ACID

(2E)-3-(4-FLUOROPHENYL)ACRYLIC ACID

4-FLUOROCINNAMIC ACID

3-(4-FLUOROPHENYL)-2-PROPENOIC ACID

3-(4-FLUORO-PHENYL)-ACRYLIC ACID

AKOS BB/0035

AKOS 92741

AKOS BBS-00006474

TRANS-4-FLUOROCINNAMIC ACID 99%

4-Fluorocinnamic acid, 98+%

4-Fluorocinnamic acid 99%

4-Fluorocinnamicacid99%

4-fluoride acid

4-FUOROCINNAMIC ACID

(E)-3-(4-Fluorophenyl)prop-2-enoic acid

3-(4-Fluorophenyl)propenoic acid

4-Fluorobenzeneacrylic acid

2-propenoic acid, 3-(4-fluorophenyl)-, (2E)-

(E)-3-(4-FL

4-FluorocinnamicAcid&gt

4-FLUOROCINNAMIC ACID CAS NO 459-32-5

4-Fluorocinnamic acid USP/EP/BP

RARECHEM BK HC T330,2-Propenoic acid, 3-(4-fluorophenyl)-,trans-4-fluorocinnamic acid,para-fluorocinnamic acid,4-fluoride acid,4-FluorocinnaMic

459-32-5

C9H7O2F

Building Blocks

Carboxylic Acids

C9

Carbonyl Compounds

CARBOXYLIC ACID

Organic Building Blocks

Alkenyl Fluorinated Building Blocks

Building Blocks

Carbonyl Compounds

Carboxylic Acids

Chemical Synthesis

Fluorinated Building Blocks

Organic Building Blocks

Organic Fluorinated Building Blocks

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pharmaceutical intermediate

Aromatic Cinnamic Acids, Esters and Derivatives

Cinnamic acid

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Acids & Esters

Fluorine Compounds

C9