3-CHLORO-4-FLUOROCINNAMIC ACID
- Product Name
- 3-CHLORO-4-FLUOROCINNAMIC ACID
- CAS No.
- 155814-22-5
- Chemical Name
- 3-CHLORO-4-FLUOROCINNAMIC ACID
- Synonyms
- RARECHEM BK HW 0061;3-Chloro-4-fluorocinnamicaci;3-CHLORO-4-FLUOROCINNAMIC ACID;3-(3-chloro-4-fluorophenyl)acrylic acid;3-CHLORO-4-FLUOROCINNAMIC ACID USP/EP/BP;(E)-3-(3-Chloro-4-fluorophenyl)-2-propenoic acid;(2E)-3-(3-chloro-4-fluorophenyl)prop-2-enoic acid;trans-3-(3-Chloro-4-fluorophenyl)-2-propenoic acid;(2E)- 3-(3-chloro-4-fluorophenyl)-2-propenoic acid;3-Chloro-4-fluorocinnamic Acid, Predominantly trans
- CBNumber
- CB9172254
- Molecular Formula
- C9H6ClFO2
- Formula Weight
- 200.59
- MOL File
- 155814-22-5.mol
3-CHLORO-4-FLUOROCINNAMIC ACID Property
- Melting point:
- 173-175°C
- Boiling point:
- 326℃
- Density
- 1.420
- Flash point:
- 151℃
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 005637
- Product name
- 3-Chloro-4-fluorocinnamicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 005637
- Product name
- 3-Chloro-4-fluorocinnamicacid
- Purity
- 98%
- Packaging
- 5g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- 9967AL
- Product name
- (E)-3-(3-Chloro-4-fluorophenyl)-2-propenoicacid
- Packaging
- 5g
- Price
- $126
- Updated
- 2021/12/16
- Product number
- 005637
- Product name
- 3-Chloro-4-fluorocinnamicacid
- Purity
- 98%
- Packaging
- 25g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CD12137940
- Product name
- 3-Chloro-4-fluorocinnamicacid
- Purity
- 95+%
- Packaging
- 100g
- Price
- $546
- Updated
- 2021/12/16
3-CHLORO-4-FLUOROCINNAMIC ACID Chemical Properties,Usage,Production
Uses
3-Chloro-4-fluorocinnamic Acid (CAS# 58537-11-4) can be used to prepare chemokine receptor modulators.
Synthesis
141-82-2
34328-61-5
155814-22-5
GENERAL METHOD: 3-chloro-4-fluorobenzaldehyde (10 mmol), malonic acid (30 mmol, 3.12 g), and piperidine (0.5 mL) were dissolved in pyridine (20 mL), and the reaction mixture was heated under reflux conditions for 4 hours. Upon completion of the reaction, the solution was cooled to room temperature and slowly poured into pre-cooled aqueous 3M HCl solution (100 mL). The precipitated white solid precipitate was collected by filtration and washed sequentially with deionized water (350 mL), 5% w/v NaHCO3 aqueous solution (20 mL) and deionized water (250 mL). The resulting solid was dried in an oven at 60 °C to constant weight. If necessary, the crude product was purified by recrystallization through EtOH/H2O mixed solvent.
References
[1] Tetrahedron, 2016, vol. 72, # 46, p. 7256 - 7262
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 409 - 416
3-CHLORO-4-FLUOROCINNAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLORO-4-FLUOROCINNAMIC ACID manufacturers
- Product
- 3-CHLORO-4-FLUOROCINNAMIC ACID 155814-22-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-10