4-Chlorocinnamic acid
- Product Name
- 4-Chlorocinnamic acid
- CAS No.
- 1615-02-7
- Chemical Name
- 4-Chlorocinnamic acid
- Synonyms
- ARBA-033;AKOS 92736;orocinnamic acid;4-Chlorociamic acid;TIMTEC-BB SBB008203;RARECHEM BK HC T318;4-Chlorocinmic acid;p-chloro-cinnamicaci;4-CHLOROCINNAMIC ACID;4-Chlorocinncmic Acid
- CBNumber
- CB1114188
- Molecular Formula
- C9H7ClO2
- Formula Weight
- 182.6
- MOL File
- 1615-02-7.mol
4-Chlorocinnamic acid Property
- Melting point:
- 248-250 °C(lit.)
- Boiling point:
- 260.71°C (rough estimate)
- Density
- 1.2377 (rough estimate)
- refractive index
- 1.5426 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 4.41(at 25℃)
- form
- Fine Crystalline Powder
- color
- White
- BRN
- 1365308
- InChI
- InChI=1S/C9H7ClO2/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6H,(H,11,12)
- InChIKey
- GXLIFJYFGMHYDY-ZZXKWVIFSA-N
- SMILES
- C(O)(=O)C=CC1=CC=C(Cl)C=C1
- CAS DataBase Reference
- 1615-02-7(CAS DataBase Reference)
- NIST Chemistry Reference
- p-Chlorocinnamic acid(1615-02-7)
- EPA Substance Registry System
- 2-Propenoic acid, 3-(4-chlorophenyl)- (1615-02-7)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 36-28A-26-24/25
- WGK Germany
- 3
- RTECS
- GD8490000
- Hazard Note
- Irritant
- HS Code
- 29163990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C31600
- Product name
- 4-Chlorocinnamic acid
- Purity
- 99%
- Packaging
- 25g
- Price
- $86.3
- Updated
- 2025/07/31
- Product number
- C0149
- Product name
- 4-Chlorocinnamic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $66
- Updated
- 2025/07/31
- Product number
- C0149
- Product name
- 4-Chlorocinnamic Acid
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $411
- Updated
- 2023/06/20
- Product number
- C4978-40
- Product name
- 4-Chlorocinnamic Acid
- Packaging
- 10g
- Price
- $418
- Updated
- 2021/12/16
- Product number
- C293310
- Product name
- 4-Chlorocinnamic acid
- Packaging
- 1000g
- Price
- $1370
- Updated
- 2021/12/16
4-Chlorocinnamic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Chlorocinnamic Acid is a derivative of Cinnamic Acid (C442030) and plays an important role in the development of plants. 4-Chlorocinnamic Acid may also show potential antimicrobial, antioxidant, anti-inflammatory, and antitumoral activity.
Definition
ChEBI: 4-chlorocinnamic acid is an organochlorine compound comprising trans-cinnamic acid having a chloro substituent at the 4-position on the phenyl ring. It is functionally related to a trans-cinnamic acid.
Synthesis
To a 100mL three-necked round-bottomed flask, 1.41g (0.01mol) of p-chlorobenzaldehyde, 1.27g (0.011mol) of malonic acid, and 0.77g (0.01mol) of ammonium acetate were added and mixed well. A thermometer and a spherical condenser tube were connected and the reaction was carried out in a microwave reactor. After the reaction was completed, 5 mL of water was heated into the flask and the unreacted p-chlorobenzaldehyde was removed by distillation with water vapor. Add 10% sodium hydroxide solution 5mL to 6mL, add activated carbon to remove the color, extract filtration, transfer the filtrate to a beaker, acidify with concentrated hydrochloric acid until the Congo red paper turns blue or pH = 3 to 4. Cool to precipitate the crystals, extract filtration, wash the precipitate with a small amount of water, extract dry, and dry the crude product. Recrystallize with water-ethanol (1:3 v/v) and dry. The yield was calculated, and the optimal synthesis conditions were: material ratio of n(p-chlorobenzaldehyde):n(malonic acid):n(ammonium acetate) = 1.0:1.1:1.0, reaction time of 13 min, power of 800 W, and a yield of 85.8% under these conditions. Melting point determination and infrared spectral analysis were carried out. Compared with the traditional method, it has the advantages of short time, high yield and less pollution.
Purification Methods
Recrystallise the acid from EtOH or aqueous EtOH (charcoal). UV has max at 275nm (EtOH). [Walling & Wolfstirn J Am Chem Soc 69 852 1947, Beilstein 9 H 596, 9 II 395, 9 III 2727, 9 IV 2033.]
4-Chlorocinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chlorocinnamic acid manufacturers
- Product
- 4-Chlorocinnamic acid 1615-02-7
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 4-Chlorocinnamic acid 1615-02-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- 4-Chlorocinnamic Acid 1615-02-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100tons
- Release date
- 2024-08-20