2-Chlorocinnamic acid
- Product Name
- 2-Chlorocinnamic acid
- CAS No.
- 3752-25-8
- Chemical Name
- 2-Chlorocinnamic acid
- Synonyms
- AKOS BBB/195;AKOS B004073;AKOS BBS-00006452;Chlorocinnamicacid;RARECHEM BK HC T319;2-Chlorocinnamicaci;o-chloro-cinnamicaci;2-CLOROCINNAMIC ACID;O-CHLOROCINNAMIC ACID;OTAVA-BB BB0125160239
- CBNumber
- CB0278409
- Molecular Formula
- C9H7ClO2
- Formula Weight
- 182.6
- MOL File
- 3752-25-8.mol
2-Chlorocinnamic acid Property
- Melting point:
- 208-210 °C(lit.)
- Boiling point:
- 260.71°C (rough estimate)
- Density
- 1.2377 (rough estimate)
- refractive index
- 1.5426 (estimate)
- storage temp.
- Room temperature.
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- Water Solubility
- Insoluble in water
- form
- powder to crystal
- pka
- 4.23(at 25℃)
- color
- White to Almost white
- BRN
- 1365198
- InChI
- InChI=1S/C9H7ClO2/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-6H,(H,11,12)
- InChIKey
- KJRRTHHNKJBVBO-AATRIKPKSA-N
- SMILES
- C(O)(=O)C=CC1=CC=CC=C1Cl
- CAS DataBase Reference
- 3752-25-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Chlorocinnamic acid(3752-25-8)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 36-26-36/37
- WGK Germany
- 3
- RTECS
- GD8450000
- Hazard Note
- Irritant
- HS Code
- 29124990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C0974
- Product name
- 2-Chlorocinnamic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- C428250
- Product name
- (E)-3-(2-Chlorophenyl)acrylicacid
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C428250
- Product name
- (E)-3-(2-Chlorophenyl)acrylicacid
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C428250
- Product name
- (E)-3-(2-Chlorophenyl)acrylicacid
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- JK331516
- Product name
- 2-Chlorocinnamic Acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $58
- Updated
- 2021/12/16
2-Chlorocinnamic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder. Insoluble in water, soluble in ethanol, ethyl acetate and other organic solvents.
Uses
2-Chlorocinnamic acid is a kind of trans-cinnamate. It is used in organic synthesis.
Biological Functions
2-Chlorocinnamic acid is a cinnamic acid derivative that inhibits the hydroxylation of phenylpropanoids. It has been shown to inhibit the activity of cinnamic acid derivatives and their hydroxylation in cell lines, which is linked to the inhibition of cellulose acetate synthesis. 2-Chlorocinnamic acid also has an inhibitory effect on the chloride ion and water molecule. The chloride ion may be needed for the formation of hydrochloric acid, which is necessary for cellulose acetate hydrolysis, while water molecules are involved in many biochemical reactions. 2-Chlorocinnamic acid affects human cell lines at temperatures between 10°C and 37°C and at regiospecific sites. This oxidative dehalogenation reaction catalyzed by R. rubra was found to be regiospecific for 2-chlorocinnamic acid; the chloride ion was probably removed after the ring fission reaction.
Synthesis
O-chlorocinnamic acid is prepared by reacting o-phthalaldehyde with malonic acid.
References
[1] Patent: EP1676838, 2006, A1. Location in patent: Page/Page column 17
[2] Patent: WO2006/69799, 2006, A1. Location in patent: Page/Page column 29-30
2-Chlorocinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chlorocinnamic acid manufacturers
- Product
- 2-Chlorocinnamic acid 3752-25-8
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-09-06
- Product
- 2-Chlorocinnamic acid 3752-25-8
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 2-Chlorocinnamic acid 3752-25-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-11