H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

Product Name: H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
CAS No.: 117399-93-6
Chemical Name: H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
Synonyms: et-3;EDN3;WS4B;HSCR4;PPET3;human,rat;ET-3, HUMAN;ENDOTHELIN-3;CAS:117399-93-6;Rat endothelin-3
CBNumber: CB7181630
Molecular Formula: C121H168N26O33S4
Formula Weight: 2643.04
MOL File: 117399-93-6.mol

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H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Property

Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: 5% acetic acid: 0.5mg/mL
form: powder
color: white
biological source: rabbit
Water Solubility: Soluble to 1 mg/ml in water
Sequence: Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

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Safety

Safety Statements: 22
WGK Germany: 3
F: 3-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E9137
Product name: Endothelin 3 human, rat
Purity: ≥97%(HPLC),powder
Packaging: 10μg
Price: $131
Updated: 2025/07/31

Sigma-Aldrich

Product number: E9137
Product name: Endothelin 3 human, rat
Purity: ≥97%(HPLC),powder
Packaging: 50μg
Price: $389
Updated: 2025/07/31

Sigma-Aldrich

Product number: SAB1410319
Product name: Anti-EDN3 antibody produced in rabbit
Purity: purified immunoglobulin, buffered aqueous solution
Packaging: 100 μg
Price: $541
Updated: 2025/07/31

Sigma-Aldrich

Product number: E9137
Product name: Endothelin 3 human, rat
Purity: ≥97%(HPLC),powder
Packaging: 0.1mg
Price: $697.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 05-23-3801
Product name: Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem
Purity: Attenuates thrombin-evoked aggregation of human platelets.
Packaging: .5mg
Price: $525
Updated: 2025/07/31

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H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Chemical Properties,Usage,Production

Uses

Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors.

General Description

Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon.

Biochem/physiol Actions

Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma.

in vivo

Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity^[3].

storage

Store at -20°C

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Suppliers

China 112 Europe 3 Germany 2 Switzerland 1 United Kingdom 2 United States 13 Global 133

GL Biochem (Shanghai) Ltd

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View Lastest Price from H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH manufacturers

Career Henan Chemical Co

Product: H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH 117399-93-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-12

Career Henan Chemical Co

Product: H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH 117399-93-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-12

117399-93-6, H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OHRelated Search:

H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH IRL-1038 Endothelin-1 (human, porcine) BIG ET-1 (1-38) (HUMAN) ENDOTHELIN (16-21) GLYCYL-L-TRYPTOPHAN Dipeptide-2 H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH N-ACETYL-L-HISTIDINE METHYL AMIDE H-ILE-ALA-OH GLYCYL-DL-TRYPTOPHAN H-LEU-BETA-ALA-OH H-GLY-GLY-TRP-OH H-VAL-GLY-GLY-OH L-ALANYL-L-TRYPTOPHAN H-ILE-TRP-OH AC-PHE-TYR-NH2 H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

ENDOTHELIN-III, HUMAN, RAT

ENDOTHELIN-3

ENDOTHELIN-3, HUMAN

ENDOTHELIN 3, HUMAN AND RAT

ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT)

ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT)

ENDOTHELIN 3 HUMAN, RAT

ENDOTHELIN-3 (HUMAN, RAT, PIG)

ENDOTHELIN-3 (HUMAN, RAT, PORCINE, RABBIT)

CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP

CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT

CTCFTYKDKECVYYCHLDIIW

CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11)

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)

ET-3, HUMAN

ET-3, HUMAN AND RAT

ET-3 (HUMAN, MOUSE, RABBIT, RAT)

ET-3 (HUMAN, RAT)

ET-3 (HUMAN, RAT, PIG)

ENDOTHELIN 3, HUMAN, RAT, 50 UG*

human,rat

et-3

M.W. 2643.04 C121H168N26O33S4

Endothelin 3【canine】

Endothelin 3【rabbit】

Endothelin 3【rat】

CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)

CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11

Endothelin-3 (huMan, Mouse, rabbit, rat) ET-3 (huMan, Mouse, rabbit, rat)

Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)

Endothelin 3 huMan, ratEndothelin

Endothelin 3 (huMan)(9CI)

Anti-EDN3 antibody produced in rabbit

EDN3

HSCR4

ANTI-EDN3 (C-TERM) antibody produced in rabbit

19: PN: WO2007112069 SEQID: 10 claimed protein

33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv.

Endothelin 3 (mouse intestine)

Human endothelin-3

Rat endothelin-3

Endothelin 3, human, rat, ≥97% (HPLC), powder

Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem

Endothelin 3 (Rat,Human)

L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide)

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP

Endothelin 3 human, rat (TFA)

Human endothelin-3/Rat endothelin-3

CAS:117399-93-6

Endothelin 3, human, rat, mouse, rabbit

(3S)-3-[[(2S)-2-[[(2S)-2-[[(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-amino-7,13-bis(4-aminobutyl)-22-benzyl-4-(2 -carboxyethyl)-10-(carboxymethyl)-19,28-bis[(1R)-1-hydroxyethyl]-16,39,42-tris[(4-hydroxyphenyl)methyl]-3,6,9,12,15,18,21,

PPET3

WS4B

117399-93-6

C121H168N26O33S4

Agonist

BioChemical