ChemicalBook > CAS DataBase List > Trolox

Trolox

Product Name
Trolox
CAS No.
53188-07-1
Chemical Name
Trolox
Synonyms
TROLOX;TROLOX;troloxc;TROLOX(R);trolox tm;TROLOXTM C;Trolox(R),97%;Trolox, 97% 1GR;Trolox, 97% 5GR;Trolox Standard
CBNumber
CB7188583
Molecular Formula
C14H18O4
Formula Weight
250.29
MOL File
53188-07-1.mol
More
Less

Trolox Property

Melting point:
187-189 °C (lit.)
Boiling point:
313.42°C (rough estimate)
Density 
1.0616 (rough estimate)
refractive index 
1.4970 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH.
pka
3.35±0.20(Predicted)
form 
Crystalline Powder
color 
White to faintly beige
BRN 
1384051
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI
InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
InChIKey
GLEVLJDDWXEYCO-UHFFFAOYSA-N
SMILES
C1(C)(C(O)=O)OC2=C(C)C(C)=C(O)C(C)=C2CC1
CAS DataBase Reference
53188-07-1(CAS DataBase Reference)
EPA Substance Registry System
3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid (53188-07-1)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
DJ2273000
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
238813
Product name
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
Purity
97%
Packaging
1g
Price
$78.1
Updated
2024/03/01
Sigma-Aldrich
Product number
238813
Product name
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
Purity
97%
Packaging
5g
Price
$194
Updated
2024/03/01
TCI Chemical
Product number
H0726
Product name
6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$67
Updated
2024/03/01
TCI Chemical
Product number
H0726
Product name
6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
10011659
Product name
Trolox
Purity
≥98%
Packaging
250mg
Price
$32
Updated
2024/03/01
More
Less

Trolox Chemical Properties,Usage,Production

Description

Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3

Chemical Properties

white to fainly beige crystalline powder

Uses

An antioxidant derived from water-soluble vitamin E

Uses

Trolox is a Vitamin E analog that also maintains the antioxidant capabilities which Vitamin E shows. Neuroprotective product.

Definition

ChEBI: A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capa ity of complex mixtures.

Application

Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. lt is commonly used as a standard or positive control in antioxidant assays.  In addition, trolox is used to assessthe role of oxidative injury in processes like neuronal cell death and aging.  It is effective as adjunctivetherapy in the treatment of certain cancers.

General Description

(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) exhibits radical scavenging and antioxidant activities.

Mechanism of action

Trolox can protect against oxidative stress, genotoxicity and inflammation induced by CS through ROS scavenging mechanism, and serve as a potential antioxidant prevention strategy against oxidative injury of ATII cells in CS-related lung diseases.

storage

Store at +4°C

References

1) Massey et al. (1990), Free radical damage in neonatal rat cardiac myocyte cultures: effects of alpha-tocopherol, Trolox and phytol; Free Radic. Biol. Med., 8 449 2) Chen et al. (1998), Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells; Mol. Pharmacol., 53 638 3) Brookes et al. (1996), Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes; Arch. Biochem. Biophys., 333 482

Trolox Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Trolox Suppliers

Americas 1 Belgium 2 Canada 2 China 223 Europe 1 France 1 Germany 3 India 8 Japan 2 Poland 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 7 United States 34 Global 288
hubei PharmaStandard Co., Ltd.
Tel
027-19050701 13545374703
Email
cbbspring@163.com
Country
China
ProdList
379
Advantage
58
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
Guizhou Yituo Chemical Technology Co., Ltd
Tel
18628235590
Fax
QQ:444176500
Email
wuliming@yituochem.cn
Country
China
ProdList
1223
Advantage
58
Shanghai URChem Limited
Tel
021-50890968 +86-18601776121;
Fax
086-21-68416099 58604179
Email
danny@urchem.com
Country
China
ProdList
528
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
028-85122536 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
2000
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5806
Advantage
50
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
3970
Advantage
60
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5902
Advantage
65
Puripharm Co., Ltd.
Tel
0572-2745768-1 13167223168
Fax
13167223168
Email
sales@puripharm.com
Country
China
ProdList
296
Advantage
65
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9942
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13856024262
Email
kuer@kuerhuaxue.com
Country
China
ProdList
2997
Advantage
55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Guangzhou LES biological Technology Co.,Ltd.
Tel
13672434928
Fax
-
Email
3307355104@qq.com
Country
China
ProdList
3650
Advantage
58
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
16509
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15497
Advantage
58
Bejing Famous Pharmaceutical Technology Co., Ltd.
Tel
13331045123
Fax
86-10-80339217
Email
1963319514@qq.com
Country
China
ProdList
14224
Advantage
58
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9897
Advantage
58
More
Less

View Lastest Price from Trolox manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID 53188-07-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Mojin Biotechnology Co., Ltd
Product
Trolox 53188-07-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
(+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97% 53188-07-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

53188-07-1, Trolox Related Search:

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Poly(ethylene glycol) dimethacrylate DICYCLOPENTANYL METHACRYLATE 2-(Perfluorohexyl)ethyl methacrylate Trimethylolpropane trimethacrylate Butyl methacrylate Methyl propiolate Trimethylolpropane triacrylate 6-Hydroxypicolinic acid Guaiazulene Trolox (S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID (R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID (S)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Succinimidyl (2R)-6-(Tetrahydro-2H-pyran-2-yloxy)-2,5,7,8-tetramethylchroman-2-carboxylate 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID 6-METHOXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-CARBOXYLIC ACID METHYL ESTER

  • 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2-carboxylicaci
  • troloxc
  • 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
  • (+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID
  • TROLOX
  • TROLOX(R)
  • TROLOXTM C
  • TIMTEC-BB SBB005933
  • trolox tm
  • (+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYL-CHRO M.-2-CARBOXYL.AC
  • rac-2,5,7,8-Tetramethyl-6-hydroxychroman-2α*-carboxylic acid
  • 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
  • Trolox(R),97%
  • Trolox, 97% 1GR
  • Trolox, 97% 5GR
  • 6-hydroxy-2,5,7,8-tetraMethychroMan-2-caboxylic acid (Trolox)
  • (+/-)-6-Hydroxy-2,5,7,8-tetraMethylchroMane-2-carboxylic acid 97%
  • 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylicAcid&gt
  • Trolox Standard
  • 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-
  • 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID ISO 9001：2015 REACH
  • 53188-07-1 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
  • 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid
  • TROLOX
  • Ferroptosis,Inhibitor,Apoptosis,Reactive Oxygen Species,inhibit,Trolox
  • 53188-07-1
  • 3188-07-1
  • Heterocyclic Building Blocks
  • Building Blocks
  • Benzopyrans