4-TRIFLUOROMETHYL-BENZAMIDINE HCL
Uses- Product Name
- 4-TRIFLUOROMETHYL-BENZAMIDINE HCL
- CAS No.
- 38980-96-0
- Chemical Name
- 4-TRIFLUOROMETHYL-BENZAMIDINE HCL
- Synonyms
- 4-TRIFLUOROMETHYL-BENZAMIDINE HCL;4-TrifluoroMethyl-benzanidibe HCL;4-Trifluoromethylbenzamidinehydrochloridel;4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE;4-TRIFLUOROMETHYL-BENZAMIDINE HCL ISO 9001：2015 REACH;4-(Trifluoromethyl)benzenecarboximidamide hydrochloride;4-(Trifluoromethyl)benzene-1-carboximidamide hydrochloride;4-(TrifluoroMethyl)benzenecarboxiMidaMide hydrochloride (1:1)
- CBNumber
- CB7199927
- Molecular Formula
- C8H8ClF3N2
- Formula Weight
- 224.61
- MOL File
- 38980-96-0.mol
4-TRIFLUOROMETHYL-BENZAMIDINE HCL Property
- Melting point:
- 158-161℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-37/39-36/37
- HS Code
- 2925290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CVT00069
- Product name
- 4-(Trifluoromethyl)benzamidine
- Packaging
- 1g
- Price
- $550
- Updated
- 2025/07/31
- Product number
- T3115
- Product name
- 4-(Trifluoromethyl)benzamidine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 200mg
- Price
- $114
- Updated
- 2025/07/31
- Product number
- T3115
- Product name
- 4-(Trifluoromethyl)benzamidine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $329
- Updated
- 2025/07/31
- Product number
- T791008
- Product name
- 4-(Trifluoromethyl)benzamidine Hydrochloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T791008
- Product name
- 4-(Trifluoromethyl)benzamidine Hydrochloride
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
4-TRIFLUOROMETHYL-BENZAMIDINE HCL Chemical Properties,Usage,Production
Uses
4-Trifluoromethylbenzamide hydrochloride is used as a pharmaceutical synthesis intermediate.
Synthesis
455-18-5
38980-96-0
4-(Trifluoromethyl)benzonitrile (15g, Avocado 14514) was used as raw material, which was dissolved in anhydrous methanol (90 ml) and sodium methanolate (0.50 g) was added. The reaction mixture was stirred at room temperature for 4 days. Subsequently, ammonium chloride (4.7 g) was added to the reaction system and stirring was continued for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and the white solid residue obtained was ground with ether, filtered and dried to afford the target product 4-(trifluoromethyl)benzamidine hydrochloride as a white solid (14.2 g, 72% yield). Mass spectrometry analysis showed a molecular ion peak of 188 [M]+.
References
[1] Patent: US2003/69276, 2003, A1
[2] Journal of the American Chemical Society, 1985, vol. 107, # 9, p. 2743 - 2748
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 4, p. 1230 - 1241
[4] Patent: US6121202, 2000, A
[5] Patent: US2012/165343, 2012, A1. Location in patent: Page/Page column 55
4-TRIFLUOROMETHYL-BENZAMIDINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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