(S)-1-(4-FLUOROPHENYL)ETHYLAMINE
- Product Name
- (S)-1-(4-FLUOROPHENYL)ETHYLAMINE
- CAS No.
- 66399-30-2
- Chemical Name
- (S)-1-(4-FLUOROPHENYL)ETHYLAMINE
- Synonyms
- (S)-1-(4-FLUOROPHENYL)ETHANAMINE;(S)-1-(4-fluorophenyl)ethan-1-amine;S-PF-PEM;(S)-(-)-4-F-phenylethylamine;1(S)-(4-Fluorophenyl)ethylamine;(S)-1-(4-FLUOROPHENYL)ETHYLAMINE;(s)-4-fluoro-à-methylbenzylamine;(S)-α-Methyl-4-fluorobenzylaMine;(S)-4-Fluoro-α-methylbenzylamine;(1S)-1-(4-Fluorophenyl)ethylamine
- CBNumber
- CB7200810
- Molecular Formula
- C8H10FN
- Formula Weight
- 139.17
- MOL File
- 66399-30-2.mol
(S)-1-(4-FLUOROPHENYL)ETHYLAMINE Property
- Melting point:
- -30°C
- Boiling point:
- 76°C 22mm
- Density
- 1,03 g/cm3
- refractive index
- 1.501
- Flash point:
- 76°C/22mm
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Miscible with dimethyl sulfoxide.
- pka
- 8.98±0.10(Predicted)
- form
- liquid
- color
- Clear
- optical activity
- Consistent with structure
- Sensitive
- Air Sensitive
- BRN
- 6791614
- CAS DataBase Reference
- 66399-30-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N,C
- Risk Statements
- 34-51/53-22
- Safety Statements
- 26-36/37/39-61-45
- RIDADR
- 2735
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F1392
- Product name
- (S)-1-(4-Fluorophenyl)ethan-1-amine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $72
- Updated
- 2025/07/31
- Product number
- F1392
- Product name
- (S)-1-(4-Fluorophenyl)ethan-1-amine
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $216
- Updated
- 2025/07/31
- Product number
- 3630-3-S4
- Product name
- (S)-1-(4-Fluorophenyl)ethylamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 3630-3-S4
- Product name
- (S)-1-(4-Fluorophenyl)ethylamine
- Purity
- 97%
- Packaging
- 5G
- Price
- $115
- Updated
- 2021/12/16
- Product number
- PC0613
- Product name
- (1S)-1-(4-Fluorophenyl)ethylamine
- Packaging
- 5g
- Price
- $174
- Updated
- 2021/12/16
(S)-1-(4-FLUOROPHENYL)ETHYLAMINE Chemical Properties,Usage,Production
Chemical Properties
Colorless transparent liquid
Uses
(S)-(-)-1-(4-Fluorophenyl)ethylamine is used in organic synthesis. It acts as a ligand and form a coordination complex, diacetato-2-O-bis[(S)-1-(4-fluorophenyl)ethylamine-N]palladium(II) by reacting with palladium(II) acetate.
Synthesis
403-42-9
66399-30-2
General procedure for the synthesis of (S)-1-(4-fluorophenyl)ethylamine using 4-fluoroacetophenone as starting material: to a vial containing 4-fluoroacetophenone (0.2 mmol, 1.0 eq.), ammonium formate (HCO2NH4, 37.8 mg, 2 mmol, 10.0 eq.), and Pdα-nanocatalyst (Pd°-AmP-MFC, 2.68 mg. 0.002 mmol, 8 wt%) were added to the vial with methanol (0.3 mL) and the reaction mixture was stirred for the time indicated in Table 4. Upon completion of the reaction, the vials were cooled in an ice bath, followed by the addition of methanol (0.367 mL) and a buffer solution (50 mM HEPES, pH 8.2, 6 mL) containing aminotransferase (ATA) and 2-5 equivalents of sodium pyruvate (1 equivalent = 0.2 mmol, 22 mg). The reaction tubes were placed under light-avoiding conditions and left to stand at room temperature for 24 h with gentle shaking on an orbital oscillator. Upon completion of the reaction, the enantiomeric excess (ee) of the product was determined by high performance liquid chromatography (HPLC) analysis (repeated three times for each sample).
References
[1] Patent: WO2016/96905, 2016, A1. Location in patent: Page/Page column 25
[2] Chemistry Letters, 2004, vol. 33, # 11, p. 1424 - 1425
[3] Journal of Organic Chemistry, 2013, vol. 78, # 11, p. 5314 - 5327
[4] Organic Process Research and Development, 2014, vol. 18, # 6, p. 788 - 792
[5] ACS Catalysis, 2016, vol. 6, # 6, p. 3932 - 3940
(S)-1-(4-FLUOROPHENYL)ETHYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-1-(4-FLUOROPHENYL)ETHYLAMINE manufacturers
- Product
- (S)-1-(4-FLUOROPHENYL)ETHYLAMINE 66399-30-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-16
- Product
- (S)-1-(4-FLUOROPHENYL)ETHYLAMINE 66399-30-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-15