NOMIFENSINE MALEATE SALT
- Product Name
- NOMIFENSINE MALEATE SALT
- CAS No.
- 32795-47-4
- Chemical Name
- NOMIFENSINE MALEATE SALT
- Synonyms
- hoe984;Alival;merital;meritalam;hostalival;NSC-289114;NOMIFENSINE MALEATE;alival(antidepressant);(±)-Nomifensine maleat;NOMIFENSINE MALEATE SALT
- CBNumber
- CB7202667
- Molecular Formula
- C20H22N2O4
- Formula Weight
- 354.4
- MOL File
- 32795-47-4.mol
NOMIFENSINE MALEATE SALT Property
- Melting point:
- 199-201°
- storage temp.
- Refrigerator, Under Inert Atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- color
- Crystals from EtOH
- Water Solubility
- Water : 2.2 mg/mL (6.21 mM; Need ultrasonic)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- NX4912800
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N1530
- Product name
- Nomifensine maleate salt
- Packaging
- 100mg
- Price
- $297
- Updated
- 2024/03/01
- Product number
- N635950
- Product name
- NomifensineMaleicAcidSalt
- Packaging
- 5g
- Price
- $1395
- Updated
- 2021/12/16
- Product number
- N635950
- Product name
- NomifensineMaleicAcidSalt
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CS-4709
- Product name
- Nomifensinemaleate
- Purity
- 99.67%
- Packaging
- 100mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- B6911
- Product name
- Nomifensine
- Packaging
- 100mg
- Price
- $240
- Updated
- 2021/12/16
NOMIFENSINE MALEATE SALT Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Originator
Alival,Hoechst,W. Germany ,1976
Uses
Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.
Uses
A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.
Uses
Antidepressant;Dopamine uptake inhibitor
Manufacturing Process
A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).
brand name
Merital (Hoechst-Roussel).
Therapeutic Function
Psychostimulant
Biochem/physiol Actions
Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.
Safety Profile
Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Human systemic effects by intravenous route: heart ratechanges, blood pressure elevation. Experimentalreproductive effects. An antidepressant. When heated to decomposition it em
storage
Store at +4°C
NOMIFENSINE MALEATE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from NOMIFENSINE MALEATE SALT manufacturers
- Product
- NOMIFENSINE MALEATE SALT 32795-47-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-26