NOMIFENSINE MALEATE SALT

Product Name: NOMIFENSINE MALEATE SALT
CAS No.: 32795-47-4
Chemical Name: NOMIFENSINE MALEATE SALT
Synonyms: hoe984;Alival;merital;meritalam;hostalival;NSC-289114;NOMIFENSINE MALEATE;alival(antidepressant);(±)-Nomifensine maleat;NOMIFENSINE MALEATE SALT
CBNumber: CB7202667
Molecular Formula: C20H22N2O4
Formula Weight: 354.4
MOL File: 32795-47-4.mol

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NOMIFENSINE MALEATE SALT Property

Melting point:: 199-201°
storage temp.: Refrigerator, Under Inert Atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
color: Crystals from EtOH
Water Solubility: Water : 2.2 mg/mL (6.21 mM; Need ultrasonic)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
RIDADR: 3249
WGK Germany: 3
RTECS: NX4912800
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1530
Product name: Nomifensine maleate salt
Packaging: 100mg
Price: $297
Updated: 2024/03/01

TRC

Product number: N635950
Product name: NomifensineMaleicAcidSalt
Packaging: 5g
Price: $1395
Updated: 2021/12/16

TRC

Product number: N635950
Product name: NomifensineMaleicAcidSalt
Packaging: 100mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-4709
Product name: Nomifensinemaleate
Purity: 99.67%
Packaging: 100mg
Price: $192
Updated: 2021/12/16

ApexBio Technology

Product number: B6911
Product name: Nomifensine
Packaging: 100mg
Price: $240
Updated: 2021/12/16

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NOMIFENSINE MALEATE SALT Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Originator

Alival,Hoechst,W. Germany ,1976

Uses

Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.

Uses

A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.

Uses

Antidepressant;Dopamine uptake inhibitor

Manufacturing Process

A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).

brand name

Merital (Hoechst-Roussel).

Therapeutic Function

Psychostimulant

Biochem/physiol Actions

Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Human systemic effects by intravenous route: heart ratechanges, blood pressure elevation. Experimentalreproductive effects. An antidepressant. When heated to decomposition it em

storage

Store at +4°C

NOMIFENSINE MALEATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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NOMIFENSINE MALEATE SALT Suppliers

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View Lastest Price from NOMIFENSINE MALEATE SALT manufacturers

Dideu Industries Group Limited

Product: NOMIFENSINE MALEATE SALT 32795-47-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-26

32795-47-4, NOMIFENSINE MALEATE SALTRelated Search:

NOMIFENSINE MALEATE Chlorphenamine maleate MALEIC ACID MONOSODIUM SALT PHENRAMINE MALEATE N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Ammonium hydrogen maleate 2-DIMETHYLAMINOMETHYL-ANILINE 4-phenyl-1,2,3,4-tetrahydroisoquinoline NOMIFENSINE MALEATE SALT

1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin(z)-2-butenedioate

1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolinmaleate

2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-8-amine

1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate

8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolinemaleate

alival(antidepressant)

hoe984

hostalival

merital

meritalam

nomifensinehydrogenmaleate

nomifensinhydrogenmaleate

NOMIFENSINE MALEATE

NOMIFENSINE MALEATE SALT

8-ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinolinium maleate

Alival

NSC-289114

1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-8-ISOQUINOLINAMINE MALEATE SALT

(±)-Nomifensine maleat

Nomifensine Maleic Acid Salt

NOMIFENSINE MALEATE SALT USP/EP/BP

2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine maleate

Dopamine Receptor,inhibit,Inhibitor,Nomifensine maleate,Nomifensine

32795-47-4

C16H18N2C4H4O4

Inhibitors

API

Heterocycles series