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NOMIFENSINE MALEATE

Product Name
NOMIFENSINE MALEATE
CAS No.
24526-64-5
Chemical Name
NOMIFENSINE MALEATE
Synonyms
linamiphen;Nomifensin;Nomifenison;NOMIFENSINE MALEATE USP/EP/BP;Dopamine Receptor,Inhibitor,Nomifensine,inhibit;1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin;2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine;8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline;8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
CBNumber
CB5503980
Molecular Formula
C16H18N2
Formula Weight
238.33
MOL File
24526-64-5.mol
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NOMIFENSINE MALEATE Property

Melting point:
179-181°
Boiling point:
370.93°C (rough estimate)
Density 
0.9597 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
2-8°C(protect from light)
solubility 
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): Partially soluble
form 
A crystalline solid
pka
7.85±0.40(Predicted)
EPA Substance Registry System
Nomifensine (24526-64-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
NX4912800
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
24526-64-5(Hazardous Substances Data)
Toxicity
TDLo orl-wmn: 7 mg/kg/7D-I:BLD BMJOAE 288,830,84
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29330
Product name
Nomifensine
Packaging
25mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
29330
Product name
Nomifensine
Packaging
50mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
29330
Product name
Nomifensine
Packaging
100mg
Price
$138
Updated
2024/03/01
ChemScene
Product number
CS-4708
Product name
Nomifensine
Purity
98.93%
Packaging
100mg
Price
$192
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0299991
Product name
2-METHYL-4-PHENYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-8-YLAMINE
Purity
95.00%
Packaging
500MG
Price
$679.14
Updated
2021/12/16
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NOMIFENSINE MALEATE Chemical Properties,Usage,Production

Description

Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 μmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.

Originator

Alival,Hoechst,W. Germany ,1976

Uses

A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.

Definition

ChEBI: An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.

Manufacturing Process

A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).

brand name

Merital (Hoechst-Roussel);Anametrin;Caribium;Hoe 984;Hostalival;Merival;Musettamycin;Neurolene;Nomival;Psicronizer;Psyton.

Therapeutic Function

Psychostimulant

World Health Organization (WHO)

Nomifensine, an antidepressant indicated for the treatment of a wide range of depressive illness, was introduced in 1976. Subsequently rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity and fever were associated with the use of the drug. Following discussions with regulatory authorities in the United Kingdom and the Federal Republic of Germany the major manufacturer withdrew all preparations containing nomifensine worldwide in January 1986.

Safety Profile

Poison by ingestion andintravenous routes. Human systemic effects by ingestion:diffuse hepatitis, hemorrhage and decrease in the numberof blood platelets (thrombocytopenia). When heated todecomposition it emits toxic fumes of NOx.

NOMIFENSINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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NOMIFENSINE MALEATE Suppliers

Canada 1 China 39 India 2 South Korea 1 United States 9 Global 52
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17987
Advantage
64
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12742
Advantage
55
Runpharm Technology Limited
Tel
18171398856 2968382473
Fax
0086-21-50758330
Email
service@runpharm.com
Country
China
ProdList
718
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9798
Advantage
50
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4992
Advantage
55
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6508
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
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View Lastest Price from NOMIFENSINE MALEATE manufacturers

Dideu Industries Group Limited
Product
NOMIFENSINE MALEATE 24526-64-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26
Career Henan Chemical Co
Product
NOMIFENSINE MALEATE 24526-64-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-09

24526-64-5, NOMIFENSINE MALEATERelated Search:

NOMIFENSINE MALEATE SALT Amitriptyline Amantadine SODIUM 4-HYDROXYBUTYRATE 4-phenyl-1,2,3,4-tetrahydroisoquinoline NOMIFENSINE MALEATE

  • 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin
  • 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin
  • 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine
  • 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
  • 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
  • 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
  • linamiphen
  • Nomifenison
  • Nomifensin
  • 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
  • NOMIFENSINE MALEATE USP/EP/BP
  • Dopamine Receptor,Inhibitor,Nomifensine,inhibit
  • 24526-64-5
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals