NOMIFENSINE MALEATE

Product Name: NOMIFENSINE MALEATE
CAS No.: 24526-64-5
Chemical Name: NOMIFENSINE MALEATE
Synonyms: linamiphen;Nomifensin;Nomifenison;NOMIFENSINE MALEATE USP/EP/BP;Dopamine Receptor,Inhibitor,Nomifensine,inhibit;1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin;2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine;8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline;8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
CBNumber: CB5503980
Molecular Formula: C16H18N2
Formula Weight: 238.33
MOL File: 24526-64-5.mol

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NOMIFENSINE MALEATE Property

Melting point:: 179-181°
Boiling point:: 370.93°C (rough estimate)
Density: 0.9597 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C(protect from light)
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): Partially soluble
form: A crystalline solid
pka: 7.85±0.40(Predicted)
color: Light yellow to yellow
EPA Substance Registry System: Nomifensine (24526-64-5)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
RIDADR: 3249
WGK Germany: 3
RTECS: NX4912800
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 24526-64-5(Hazardous Substances Data)
Toxicity: TDLo orl-wmn: 7 mg/kg/7D-I:BLD BMJOAE 288,830,84

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29330
Product name: Nomifensine
Packaging: 25mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29330
Product name: Nomifensine
Packaging: 50mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 29330
Product name: Nomifensine
Packaging: 100mg
Price: $138
Updated: 2024/03/01

ChemScene

Product number: CS-4708
Product name: Nomifensine
Purity: 98.93%
Packaging: 50mg
Price: $108
Updated: 2021/12/16

ChemScene

Product number: CS-4708
Product name: Nomifensine
Purity: 98.93%
Packaging: 100mg
Price: $192
Updated: 2021/12/16

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NOMIFENSINE MALEATE Chemical Properties,Usage,Production

Description

Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC₅₀ values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D₂, α₁- adrenergic-, 5-HT₂, and muscarinic receptors (IC₅₀s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 μmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.

Originator

Alival,Hoechst,W. Germany ,1976

Uses

A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.

Definition

ChEBI: An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.

Manufacturing Process

A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).

brand name

Merital (Hoechst-Roussel);Anametrin;Caribium;Hoe 984;Hostalival;Merival;Musettamycin;Neurolene;Nomival;Psicronizer;Psyton.

Therapeutic Function

Psychostimulant

World Health Organization (WHO)

Nomifensine, an antidepressant indicated for the treatment of a wide range of depressive illness, was introduced in 1976. Subsequently rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity and fever were associated with the use of the drug. Following discussions with regulatory authorities in the United Kingdom and the Federal Republic of Germany the major manufacturer withdrew all preparations containing nomifensine worldwide in January 1986.

Safety Profile

Poison by ingestion andintravenous routes. Human systemic effects by ingestion:diffuse hepatitis, hemorrhage and decrease in the numberof blood platelets (thrombocytopenia). When heated todecomposition it emits toxic fumes of NOx.

NOMIFENSINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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NOMIFENSINE MALEATE Suppliers

Canada 1 China 44 India 2 South Korea 1 United States 10 Global 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19173
Advantage: 64

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Runpharm Technology Limited

Tel: 18171398856 2968382473
Fax: 0086-21-50758330
Email: service@runpharm.com
Country: China
ProdList: 716
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

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View Lastest Price from NOMIFENSINE MALEATE manufacturers

Dideu Industries Group Limited

Product: NOMIFENSINE MALEATE 24526-64-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-26

Career Henan Chemical Co

Product: NOMIFENSINE MALEATE 24526-64-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-09

24526-64-5, NOMIFENSINE MALEATERelated Search:

NOMIFENSINE MALEATE SALT Amitriptyline Amantadine SODIUM 4-HYDROXYBUTYRATE 4-phenyl-1,2,3,4-tetrahydroisoquinoline NOMIFENSINE MALEATE

1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin

1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin

2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline

8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-

linamiphen

Nomifenison

Nomifensin

2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine

NOMIFENSINE MALEATE USP/EP/BP

Dopamine Receptor,Inhibitor,Nomifensine,inhibit

24526-64-5

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals