NOMIFENSINE MALEATE

Product Name: NOMIFENSINE MALEATE
CAS No.: 24526-64-5
Chemical Name: NOMIFENSINE MALEATE
Synonyms: linamiphen;Nomifensin;Nomifenison;NOMIFENSINE MALEATE USP/EP/BP;Dopamine Receptor,Inhibitor,Nomifensine,inhibit;1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin;2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine;8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline;8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
CBNumber: CB5503980
Molecular Formula: C16H18N2
Formula Weight: 238.33
MOL File: 24526-64-5.mol

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NOMIFENSINE MALEATE Property

Melting point:: 179-181°
Boiling point:: 370.93°C (rough estimate)
Density: 0.9597 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C(protect from light)
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): Partially soluble
form: A crystalline solid
pka: 7.85±0.40(Predicted)
EPA Substance Registry System: Nomifensine (24526-64-5)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
RIDADR: 3249
WGK Germany: 3
RTECS: NX4912800
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 24526-64-5(Hazardous Substances Data)
Toxicity: TDLo orl-wmn: 7 mg/kg/7D-I:BLD BMJOAE 288,830,84

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29330
Product name: Nomifensine
Packaging: 25mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29330
Product name: Nomifensine
Packaging: 50mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 29330
Product name: Nomifensine
Packaging: 100mg
Price: $138
Updated: 2024/03/01

ChemScene

Product number: CS-4708
Product name: Nomifensine
Purity: 98.93%
Packaging: 100mg
Price: $192
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0299991
Product name: 2-METHYL-4-PHENYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-8-YLAMINE
Purity: 95.00%
Packaging: 500MG
Price: $679.14
Updated: 2021/12/16

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NOMIFENSINE MALEATE Chemical Properties,Usage,Production

Description

Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC₅₀ values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D₂, α₁- adrenergic-, 5-HT₂, and muscarinic receptors (IC₅₀s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 μmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.

Originator

Alival,Hoechst,W. Germany ,1976

Uses

A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.

Definition

ChEBI: An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.

Manufacturing Process

A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).

brand name

Merital (Hoechst-Roussel);Anametrin;Caribium;Hoe 984;Hostalival;Merival;Musettamycin;Neurolene;Nomival;Psicronizer;Psyton.

Therapeutic Function

Psychostimulant

World Health Organization (WHO)

Nomifensine, an antidepressant indicated for the treatment of a wide range of depressive illness, was introduced in 1976. Subsequently rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity and fever were associated with the use of the drug. Following discussions with regulatory authorities in the United Kingdom and the Federal Republic of Germany the major manufacturer withdrew all preparations containing nomifensine worldwide in January 1986.

Safety Profile

Poison by ingestion andintravenous routes. Human systemic effects by ingestion:diffuse hepatitis, hemorrhage and decrease in the numberof blood platelets (thrombocytopenia). When heated todecomposition it emits toxic fumes of NOx.

NOMIFENSINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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NOMIFENSINE MALEATE Suppliers

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View Lastest Price from NOMIFENSINE MALEATE manufacturers

Dideu Industries Group Limited

Product: NOMIFENSINE MALEATE 24526-64-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-26

Career Henan Chemical Co

Product: NOMIFENSINE MALEATE 24526-64-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-09

24526-64-5, NOMIFENSINE MALEATERelated Search:

NOMIFENSINE MALEATE SALT Amitriptyline Amantadine SODIUM 4-HYDROXYBUTYRATE 4-phenyl-1,2,3,4-tetrahydroisoquinoline NOMIFENSINE MALEATE

1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin

1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin

2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline

8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-

linamiphen

Nomifenison

Nomifensin

2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine

NOMIFENSINE MALEATE USP/EP/BP

Dopamine Receptor,Inhibitor,Nomifensine,inhibit

24526-64-5

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals