3-Aminopiperidine dihydrochloride
- Product Name
- 3-Aminopiperidine dihydrochloride
- CAS No.
- 138060-07-8
- Chemical Name
- 3-Aminopiperidine dihydrochloride
- Synonyms
- piperidin-3-amine;3-AMINOPIPERIDINEHCL;3-AMINOPIPERIDINEDIHCL;3-AMINOPIPERIDINE 2HCL;Linagliptin Impurity 91;3-aminopiperidine hydrochloride;piperidin-3-amine hydrochloride;3-Piperidinamine dihydrochloride;3-AMINOPIPERIDINE DIHYDROCHLORIDE;Piperidin-3-amine dihydrochloride
- CBNumber
- CB7205466
- Molecular Formula
- C5H14Cl2N2
- Formula Weight
- 173.08
- MOL File
- 138060-07-8.mol
3-Aminopiperidine dihydrochloride Property
- Melting point:
- 230 °C (dec.)(lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Methanol (Sparingly), Water (Slightly)
- form
- Powder
- color
- Off-white to beige
- Water Solubility
- Partly miscible in water.
- Sensitive
- Hygroscopic
- CAS DataBase Reference
- 138060-07-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A616355
- Product name
- 3-Aminopiperidine dihydrochloride
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- L480
- Product name
- 3-Aminopiperidine2HCl
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- OR6131
- Product name
- 3-Aminopiperidine dihydrochloride
- Purity
- 95+%
- Packaging
- 10g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 3H30-5-61
- Product name
- 3-Aminopiperidine dihydrochloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 074018
- Product name
- 3-Aminopiperidine dihydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
3-Aminopiperidine dihydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-white to beige powder
Uses
Reactant for N-arylation of heterocyclic diamines Reactant for synthesis of substituted quinolones with reduced phototoxic risk
Uses
It is used as a reactant for N-arylation of heterocyclic diamines and for synthesis of substituted quinolones with reduced phototoxic risk.
Uses
Reactant for N-arylation of heterocyclic diamines
Reactant for synthesis of substituted quinolones with reduced phototoxic risk
General Description
Estimation of (S)-piperidin-3-amine in (R)-piperidin-3-amine dihydrochloride (3-aminopiperidine dihydrochloride) has been investigated by chiral high-performance liquid chromatographic (chiral HPLC) method.
Synthesis
689758-90-5
127294-75-1
The general procedure for the synthesis of 3-piperidinamine hydrochloride from piperidine-3-carbohydrazide was as follows: 36 g (250 mmol) of racemic piperidine carbohydrazide was added to 125 g of water under ice/salt bath cooling conditions, followed by the addition of 45 mL (500 mmol) of concentrated hydrochloric acid. Keeping the reaction temperature at 0 °C, 25.1 g of isoamyl nitrite (300 mmol) was slowly added over 30 min and stirring was continued at the same temperature for 30 min. The reaction was monitored by HPLC to confirm the complete conversion of piperidine carbohydrazide to the target azide and no starting material remained. The reaction mixture was poured dropwise into 500 mL of water preheated to 80 °C over 10 min and subsequently boiled for 60 min. Upon completion of the reaction, the solution was cooled to room temperature, 40 mL of concentrated hydrochloric acid was added and the solution was concentrated to a viscous state. The solution was again concentrated by adding 100 mL of water, followed by the addition of 100 mL of isopropanol and repeating the concentration process. The residue was dissolved in 50 mL of hot methanol and 100 g of acetone was added dropwise to the cooled methanol solution under vigorous stirring to induce precipitation of 3-aminopiperidine dihydrochloride (40 g of wet product). The product was dried with two portions (50 mL each) of isopropanol by azeotropic distillation under reduced pressure. The dried product was suspended in hot methanol and stirred overnight at room temperature. Subsequently, the suspension was diluted with 70 g of acetone and the solid product was separated by filtration. Finally 33.2 g (192 mmol, 77% yield) of 3-aminopiperidine dihydrochloride was obtained as a white powder. The product had a chemical purity of 98.7% by HPLC and a water content of 0.046% by Karl Fischer titration.
References
[1] Patent: WO2014/128139, 2014, A1. Location in patent: Page/Page column 33
3-Aminopiperidine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-Aminopiperidine dihydrochloride Suppliers
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View Lastest Price from 3-Aminopiperidine dihydrochloride manufacturers
- Product
- 3-Aminopiperidine dihydrochloride 138060-07-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-04-29
- Product
- 3-Aminopiperidine dihydrochloride 138060-07-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 3-Aminopiperidine dihydrochloride 138060-07-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-08