ChemicalBook > CAS DataBase List > 2-Fluoroethyl 4-methylbenzenesulfonate

2-Fluoroethyl 4-methylbenzenesulfonate

Product Name
2-Fluoroethyl 4-methylbenzenesulfonate
CAS No.
383-50-6
Chemical Name
2-Fluoroethyl 4-methylbenzenesulfonate
Synonyms
Fluoroethylp-tosylate;2-FLUOROETHYL TOSYLATE;2-Fluoroethanol tosylate;L-TRYPTOPHAN/D-TRYPTOPHAN;2-Fluoroethyl 4-methylben;FLUOROETHYL 4-TOLUENESULFONATE;Fluoroethyl p-toluenesulfonate;2-Fluoro-ethanol 1-( tosylate);2-Fluoroethyl p-Toluenesulfonate;2-fluoroethyl 4-methylbenzenesulfonate
CBNumber
CB7206867
Molecular Formula
C9H11FO3S
Formula Weight
218.25
MOL File
383-50-6.mol
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2-Fluoroethyl 4-methylbenzenesulfonate Property

Boiling point:
140°C/1mmHg(lit.)
Density 
1.290 g/cm3
refractive index 
1.5060 to 1.5100
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
color 
Clear Colourless to Pale Brown
InChI
InChI=1S/C9H11FO3S/c1-8-2-4-9(5-3-8)14(11,12)13-7-6-10/h2-5H,6-7H2,1H3
InChIKey
XNRDLSNSMTUXBV-UHFFFAOYSA-N
SMILES
C(OS(C1=CC=C(C)C=C1)(=O)=O)CF
CAS DataBase Reference
383-50-6(CAS DataBase Reference)
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Safety

HS Code 
2930909899
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1056
Product name
2-Fluoroethyl p-Toluenesulfonate
Purity
>98.0%(GC)
Packaging
1g
Price
$181
Updated
2025/07/31
TCI Chemical
Product number
F1056
Product name
2-Fluoroethyl p-Toluenesulfonate
Purity
>98.0%(GC)
Packaging
5g
Price
$451
Updated
2025/07/31
TRC
Product number
F591735
Product name
2-FluoroethylTosylate
Packaging
1g
Price
$100
Updated
2021/12/16
TRC
Product number
F591735
Product name
2-FluoroethylTosylate
Packaging
250mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J94890
Product name
2-Fluoroethyl4-methylbenzenesulfonate
Packaging
1g
Price
$49
Updated
2021/12/16
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2-Fluoroethyl 4-methylbenzenesulfonate Chemical Properties,Usage,Production

Uses

2-Fluoroethyl Tosylate is an intermediate used in the preparation and pre-clinical evaluation of new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer by positron emission tomography (PET) imaging.

Synthesis

371-62-0

98-59-9

383-50-6

2-Fluoroethanol (1.00 mL, 16.9 mmol), p-toluenesulfonyl chloride (3.85 g, 20.2 mmol), N-methylmorpholine (9.30 mL, 84.5 mmol), and dichloromethane (50 mL) were added to the reaction vessel, and the reaction was stirred for 17 hours at room temperature. After completion of the reaction, water was added to the reaction system and extracted with ethyl acetate three times to combine the organic layers. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was purified by fast silica gel column chromatography (eluent: ethyl acetate/hexane=19:81→40:60) to afford fluoroethyl p-toluenesulfonate (3.79 g, 17.2 mmol, yield >100%) as a pale yellow liquid.1H NMR (600 MHz, CDCl3): δ 7.81 (d, J=8.4 Hz, 2H), δ 7.36 (d, J=8.4 Hz, 2H), 4.63-4.60 (m, 1H), 4.55-4.52 (m, 1H), 4.31-4.27 (m, 1H), 4.26-4.23 (m, 1H), 2.46 (s, 3H). lRMS (EI) Calculated value (C9H11F3O): 218.0, measured value: 218.0.

References

[1] Patent: US2018/30074, 2018, A1. Location in patent: Paragraph 0188-0191
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 7, p. 286 - 292
[3] Patent: US2013/177501, 2013, A1. Location in patent: Paragraph 0168
[4] Patent: US9168317, 2015, B2. Location in patent: Page/Page column 25; 26
[5] Patent: US9314541, 2016, B2. Location in patent: Page/Page column 26

2-Fluoroethyl 4-methylbenzenesulfonate Preparation Products And Raw materials

Raw materials

Tosyl chloride 2-Fluoroethanol

Preparation Products

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2-Fluoroethyl 4-methylbenzenesulfonate Suppliers

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View Lastest Price from 2-Fluoroethyl 4-methylbenzenesulfonate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09
Shaanxi Dideu Medichem Co. Ltd
Product
2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-06-25
Honest Joy Holdings Limited
Product
2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
Price
US $0.00/KG
Min. Order
1KG
Purity
97.5%
Supply Ability
100 tons
Release date
2022-02-21

383-50-6, 2-Fluoroethyl 4-methylbenzenesulfonateRelated Search:

Ethyl p-toluenesulfonate P-Toluenesulfonic anhydride p-Toluenesulfonic acid Iron(III) p-toluenesulfonate Tosufloxacin tosylate Sodium p-toluenesulfonate Propargyl p-toluenesulfonate Methyl 2-(4-methylphenylsulfonamido)acetate 3-Butynyl p-toluenesulfonate 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE HEXAFLUOROISOPROPYL TOSYLATE 1H,1H-PENTAFLUOROPROPYL P-TOLUENESULFONATE 2,2,3,3,4,4,4-HEPTAFLUOROBUTYL P-TOLUENESULFONATE 1H,1H,5H-OCTAFLUOROPENTYL P-TOLUENESULFONATE 1H,1H-PERFLUOROHEPTYL P-TOLUENESULFONATE 1H,1H,7H-DODECAFLUOROHEPTYL P-TOLUENESULFONATE 4-(HEPTAFLUOROISOPROPOXY)HEXAFLUOROBUTANOIC ACID 1H,1H,9H-PERFLUORONONYL P-TOLUENESULFONATE

  • Fluoroethylp-tosylate
  • 2-Fluoro-(4-methylbenzenesulfonate)ethanol
  • FLUOROETHYL 4-TOLUENESULFONATE
  • 2-FLUOROETHYL TOSYLATE
  • L-TRYPTOPHAN/D-TRYPTOPHAN
  • 2-fluoroethyl 4-methylbenzenesulfonate
  • Fluoroethyl p-toluenesulfonate
  • 4-Methylbenzenesulfonic acid 2-fluoro-ethyl ester
  • 2-fluoroethyl 4-Methylbenzene-1-sulfonate
  • Toluene-4-sulfonic acid 2-fluoroethyl ester
  • 2-Fluoroethyl <i>p</i>-Toluenesulfonate
  • 2-Fluoroethyl p-Toluenesulfonate
  • Ethanol, 2-fluoro-, 1-(4-methylbenzenesulfonate)
  • p-Toluenesulfonic Acid 2-Fluoroethyl Ester
  • 2-Fluoroethyl 4-methylben
  • 2-fluoro-Ethanol 1-(4-methylbenzenesulfonate)
  • 2-Fluoroethanol tosylate
  • 2-Fluoro-ethanol 1-( tosylate)
  • 383-50-6
  • C9H12FO3S
  • C9H11FO3S