5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

Product Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
CAS No.: 648450-29-7
Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
Synonyms: AS605240;AS-605240, >=98%;AS-605240(AS 605240);PI 3-Kinase Inhibitor (AS605240);PI 3-Kγ Inhibitor AS-605240 AS605240;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, 98%, a specific inhibitor of PI3Kγ;PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem;5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
CBNumber: CB72100624
Molecular Formula: C12H7N3O2S
Formula Weight: 257.27
MOL File: 648450-29-7.mol

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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Property

Density: 1.553±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble1mg/mL, clear (warmed)
pka: 6.02±0.20(Predicted)
form: powder
color: , faint red to orange to dark brown

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0233
Product name: AS605240
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $97.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 528106
Product name: PI 3-Kγ Inhibitor
Packaging: 5mg
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 10007707
Product name: AS-605240
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10007707
Product name: AS-605240
Purity: ≥98%
Packaging: 5mg
Price: $56
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0233
Product name: AS605240
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $234.8
Updated: 2024/03/01

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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Chemical Properties,Usage,Production

Uses

AS605240 has been used:

as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
as a class 1A PI3K inhibitor?to treat CD4⁺?T cells.

Definition

ChEBI: (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione is a quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an anti-inflammatory agent and an antirheumatic drug. It is a quinoxaline derivative and a member of thiazolidinediones.

Biological Activity

Potent and selective inhibitor of PI 3-kinase γ (PI3K γ ) (IC 50 = 8 nM). Displays 30-fold selectivity over PI3K δ and PI3K β and 7.5-fold selectivity over PI3K α . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Biochem/physiol Actions

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.

References

[1]. camps m, rückle t, ji h, et al. blockade of pi3kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis[j]. nature medicine, 2005, 11(9): 936-943.
[2]. marone r, cmiljanovic v, giese b, et al. targeting phosphoinositide 3-kinase—moving towards therapy[j]. biochimica et biophysica acta (bba)-proteins and proteomics, 2008, 1784(1): 159-185.

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Preparation Products And Raw materials

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View Lastest Price from 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione manufacturers

Career Henan Chemical Co

Product: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione 648450-29-7
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

AS605240

5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

PI 3-Kinase Inhibitor (AS605240) B-0301

AS-605240, >=98%

(E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione

2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-

AS-605240(AS 605240)

(Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione AS-605240

AS-605240 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

AS-605240, 98%, a specific inhibitor of PI3Kγ

PI 3-Kinase Inhibitor (AS605240)

AS 605240,5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione USP/EP/BP

5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione

PI 3-Kγ Inhibitor AS-605240 AS605240

648450-29-7

348450-29-7

Inhibitors

API

Akt

mTOR

PI3K