ChemicalBook > CAS DataBase List > 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

Product Name
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
CAS No.
648450-29-7
Chemical Name
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
Synonyms
AS605240;AS-605240, >=98%;AS-605240(AS 605240);PI 3-Kinase Inhibitor (AS605240);PI 3-Kγ Inhibitor AS-605240 AS605240;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, 98%, a specific inhibitor of PI3Kγ;PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem;5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
CBNumber
CB72100624
Molecular Formula
C12H7N3O2S
Formula Weight
257.27
MOL File
648450-29-7.mol
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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Property

Density 
1.553±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble1mg/mL, clear (warmed)
pka
6.02±0.20(Predicted)
form 
powder
color 
, faint red to orange to dark brown
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0233
Product name
AS605240
Purity
≥98% (HPLC)
Packaging
5mg
Price
$97.8
Updated
2024/03/01
Sigma-Aldrich
Product number
528106
Product name
PI 3-Kγ Inhibitor
Packaging
5mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
10007707
Product name
AS-605240
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10007707
Product name
AS-605240
Purity
≥98%
Packaging
5mg
Price
$56
Updated
2024/03/01
Sigma-Aldrich
Product number
A0233
Product name
AS605240
Purity
≥98% (HPLC)
Packaging
25mg
Price
$234.8
Updated
2024/03/01
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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Chemical Properties,Usage,Production

Uses

AS605240 has been used:

  • as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
  • as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
  • as a class 1A PI3K inhibitor?to treat CD4+?T cells.

Definition

ChEBI: (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione is a quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an anti-inflammatory agent and an antirheumatic drug. It is a quinoxaline derivative and a member of thiazolidinediones.

Biological Activity

Potent and selective inhibitor of PI 3-kinase γ (PI3K γ ) (IC 50 = 8 nM). Displays 30-fold selectivity over PI3K δ and PI3K β and 7.5-fold selectivity over PI3K α . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Biochem/physiol Actions

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.

References

[1]. camps m, rückle t, ji h, et al. blockade of pi3kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis[j]. nature medicine, 2005, 11(9): 936-943.
[2]. marone r, cmiljanovic v, giese b, et al. targeting phosphoinositide 3-kinase—moving towards therapy[j]. biochimica et biophysica acta (bba)-proteins and proteomics, 2008, 1784(1): 159-185.

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Suppliers

AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
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Target molecule Corp.
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857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
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United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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57511
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View Lastest Price from 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione manufacturers

Career Henan Chemical Co
Product
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione 648450-29-7
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

648450-29-7, 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedioneRelated Search:


  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
  • AS605240
  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
  • PI 3-Kinase Inhibitor (AS605240) B-0301
  • AS-605240, >=98%
  • (E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione
  • 2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-
  • AS-605240(AS 605240)
  • (Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione AS-605240
  • AS-605240 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
  • AS-605240, 98%, a specific inhibitor of PI3Kγ
  • PI 3-Kinase Inhibitor (AS605240)
  • AS 605240,5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
  • PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem
  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione USP/EP/BP
  • 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
  • PI 3-Kγ Inhibitor AS-605240 AS605240
  • 648450-29-7
  • 348450-29-7
  • Inhibitors
  • API
  • Akt
  • mTOR
  • PI3K