AS 604850

Product Name: AS 604850
CAS No.: 648449-76-7
Chemical Name: AS 604850
Synonyms: CS-538;AS 604850;AS-604850;AS 604850;AS 604850 USP/EP/BP;PI 3-Kγ Inhibitor II;PI 3-Kγ Inhibitor II;AS-604850, 10 mM in DMSO;AS604850; AS 604850; AS-604850;PI 3-Kinase Inhibitor (AS604850);PI 3-Kinase Inhibitor (AS604850) B-0302
CBNumber: CB5972768
Molecular Formula: C11H5F2NO4S
Formula Weight: 285.22
MOL File: 648449-76-7.mol

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AS 604850 Property

Density: 1.71
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: solid
pka: 7.07±0.20(Predicted)
color: off-white

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0231
Product name: AS 604850
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $150
Updated: 2025/07/31

Sigma-Aldrich

Product number: 528108
Product name: PI 3-Kγ Inhibitor II
Packaging: 5mg
Price: $280
Updated: 2025/07/31

Cayman Chemical

Product number: 10010175
Product name: AS 604850
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 10010175
Product name: AS 604850
Purity: ≥98%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0231
Product name: AS 604850
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $848
Updated: 2023/06/20

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AS 604850 Chemical Properties,Usage,Production

Description

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P₂ and PtdIns-(3,4,5)-P₃. PI3Kγ is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC₅₀ values of 0.25, >20, >20, and 4.5 μM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC₅₀ value of 21 μM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED₅₀ value of 42.4 mg/kg.

Uses

AS-604850 is a selective and ATP-competitive phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor.

in vivo

AS-604850 (10-100 mg/kg; oral administration; for 4.5 or 4.25 hours; Balb/C or C3H mice) treatment reduces RANTES-induced peritoneal neutrophil recruitment with an ED₅₀ value of 42.4 mg/kg. In the thioglycollate-induced peritonitis model, oral administration of 10 mg/kg AS-604850 results in a 31% reduction of neutrophil recruitment^[1].

Animal Model:	Balb/C or C3H mice with human recombinant RANTES or thioglycollate^[1]
Dosage:	10 mg/kg, 30 mg/kg or 100 mg/kg
Administration:	Oral administration; for 4.5 or 4.25 hours
Result:	Reduced RANTES-induced peritoneal neutrophil recruitment with an ED₅₀ value of 42.4 mg/kg. In the thioglycollate-induced peritonitis model, resulted in a 31% reduction of neutrophil recruitment.

IC 50

PI3Kγ: 0.25 μM (IC₅₀); PI3Kγ: 0.18 μM (Ki); PI3Kα: 4.5 μM (IC₅₀)

References

1. camps m, rückle t, ji h et al. blockade of pi3k-gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. nat med. 2005 sep;11(9):936-43.2. hohenester s, gates a, wimmer r et al. phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. j hepatol. 2010 nov;53(5):918-26.

AS 604850 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS 604850 Suppliers

China 111 India 1 Switzerland 1 United Kingdom 1 United States 18 Global 132

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

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View Lastest Price from AS 604850 manufacturers

Career Henan Chemical Co

Product: AS 604850 648449-76-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-07-09

648449-76-7, AS 604850Related Search:

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AS 604850

PI3Kγ inhibitor, 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

PI 3-Kinase Inhibitor (AS604850) B-0302

(Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

AS-604850;AS 604850

PI 3-Kγ Inhibitor II

5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]thiazolidine-2,4-dione

PI 3-Kinase Inhibitor (AS604850)

CS-538

AS604850; AS 604850; AS-604850

PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem

2,4-Thiazolidinedione, 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-

AS 604850 USP/EP/BP

PI 3-Kγ Inhibitor II AS-604850 AS604850

5-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

AS-604850, ATP-competitive PI3Kgamma inhibitor

AS-604850, 10 mM in DMSO

PI 3-Kγ Inhibitor II

648449-76-7

C11H5F2NO4S

Akt

mTOR

PI3K

Inhibitors