AS 604850

ChemicalBook > CAS DataBase List > AS 604850

Product Name: AS 604850
CAS No.: 648449-76-7
Chemical Name: AS 604850
Synonyms: CS-538;AS 604850;AS-604850;AS 604850;AS 604850 USP/EP/BP;PI 3-Kγ Inhibitor II;AS-604850, 10 mM in DMSO;AS604850; AS 604850; AS-604850;PI 3-Kinase Inhibitor (AS604850);PI 3-Kinase Inhibitor (AS604850) B-0302;PI 3-Kγ Inhibitor II AS-604850 AS604850
CBNumber: CB5972768
Molecular Formula: C11H5F2NO4S
Formula Weight: 285.22
MOL File: 648449-76-7.mol

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AS 604850 Property

Density: 1.71
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: solid
pka: 7.07±0.20(Predicted)
color: off-white

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0231
Product name: AS 604850
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $171
Updated: 2024/03/01

Sigma-Aldrich

Product number: 528108
Product name: PI 3-Kγ Inhibitor II
Packaging: 5mg
Price: $272
Updated: 2024/03/01

Cayman Chemical

Product number: 10010175
Product name: AS 604850
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 10010175
Product name: AS 604850
Purity: ≥98%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0231
Product name: AS 604850
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $848
Updated: 2023/06/20

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AS 604850 Chemical Properties,Usage,Production

Description

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P₂ and PtdIns-(3,4,5)-P₃. PI3Kγ is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC₅₀ values of 0.25, >20, >20, and 4.5 μM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC₅₀ value of 21 μM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED₅₀ value of 42.4 mg/kg.

Uses

AS-604850 is a selective and ATP-competitive phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor.

References

1. camps m, rückle t, ji h et al. blockade of pi3k-gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. nat med. 2005 sep;11(9):936-43.2. hohenester s, gates a, wimmer r et al. phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. j hepatol. 2010 nov;53(5):918-26.

AS 604850 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS 604850 Suppliers

China 90 India 1 Switzerland 1 United Kingdom 1 United States 18 Global 111

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View Lastest Price from AS 604850 manufacturers

Career Henan Chemical Co

Product: AS 604850 648449-76-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-07-09

648449-76-7, AS 604850Related Search:

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AS 604850

PI3Kγ inhibitor, 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

PI 3-Kinase Inhibitor (AS604850) B-0302

(Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

AS-604850;AS 604850

PI 3-Kγ Inhibitor II

5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]thiazolidine-2,4-dione

PI 3-Kinase Inhibitor (AS604850)

CS-538

AS604850; AS 604850; AS-604850

PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem

2,4-Thiazolidinedione, 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-

AS 604850 USP/EP/BP

PI 3-Kγ Inhibitor II AS-604850 AS604850

5-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

AS-604850, ATP-competitive PI3Kgamma inhibitor

AS-604850, 10 mM in DMSO

648449-76-7

C11H5F2NO4S

Akt

mTOR

PI3K

Inhibitors