1-Boc-4-bromopyrazole
- Product Name
- 1-Boc-4-bromopyrazole
- CAS No.
- 1150271-23-0
- Chemical Name
- 1-Boc-4-bromopyrazole
- Synonyms
- 1-Boc-4-bromopyrazole;N-Boc-4-broMopyrazole;1-
Boc- 4- bromopyrazole;tert-butyl 4-bromopyrazole-1-carboxylate;t-Butyl 4-bromo-1H-pyrazole-1-carboxylate;tert-Butyl 4-bromo-1H-pyrazol-1-carboxylate;1H-Pyrazole-1-carboxylic acid, 4-bromo-, 1,1-dimethylethyl ester - CBNumber
- CB72101292
- Molecular Formula
- C8H11BrN2O2
- Formula Weight
- 247.09
- MOL File
- 1150271-23-0.mol
1-Boc-4-bromopyrazole Property
- Melting point:
- 48-52 °C
- Boiling point:
- 288.7±32.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- -3.17±0.12(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C8H11BrN2O2/c1-8(2,3)13-7(12)11-5-6(9)4-10-11/h4-5H,1-3H3
- InChIKey
- IQEFCRDQVLIADR-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)C=C(Br)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 694266
- Product name
- 1-Boc-4-bromopyrazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $127
- Updated
- 2023/06/20
- Product number
- 694266
- Product name
- 1-Boc-4-bromopyrazole
- Purity
- 97%
- Packaging
- 10g
- Price
- $603
- Updated
- 2023/06/20
- Product number
- B201143
- Product name
- 1-BOC-4-bromopyrazole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 408958
- Product name
- 1-BOC-4-bromopyrazole
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- B201143
- Product name
- 1-BOC-4-bromopyrazole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
1-Boc-4-bromopyrazole Chemical Properties,Usage,Production
Synthesis
2075-45-8
24424-99-5
1150271-23-0
Step 1: Preparation of tert-butyl 4-bromo-1H-pyrazole-1-carboxylate Di-tert-butyl dicarbonate (Boc2O, 2.34 mL, 10.2 mmol) was slowly added to a solution of 4-bromo-1H-pyrazole (1 g, 6.8 mmol) in acetonitrile (20 mL) at 0 °C. Subsequently, triethylamine (3.3 mL, 23.8 mmol) and 4-dimethylaminopyridine (DMAP, 0.166 g, 1.36 mmol) were added sequentially to the reaction mixture. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (100 mL × 3). The organic phases were combined, washed sequentially with water (100 mL) and saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to afford tert-butyl 4-bromo-1H-pyrazole-1-carboxylate (1.65 g, 98% yield) as a colorless liquid. 1H NMR (400 MHz, CDCl3) δ 8.09 (s, 1H), 7.66 (s, 1H), 1.65 (s, 9H).
References
[1] Patent: WO2016/49165, 2016, A1. Location in patent: Paragraph 00161
[2] Patent: WO2018/172250, 2018, A1. Location in patent: Page/Page column 300
[3] Patent: CN106188116, 2016, A. Location in patent: Paragraph 0016
[4] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 142
[5] Arkivoc, 2014, vol. 2014, # 6, p. 54 - 71
1-Boc-4-bromopyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-4-bromopyrazole Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 1-Boc-4-bromopyrazole manufacturers
- Product
- 1-Boc-4-bromopyrazole 1150271-23-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 1-Boc-4-bromopyrazole 1150271-23-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 1-Boc-4-bromopyrazole 1150271-23-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02