ChemicalBook > CAS DataBase List > Cevimeline Hydrochloride Salt
Cevimeline Hydrochloride Salt
- Product Name
- Cevimeline Hydrochloride Salt
- CAS No.
- 107220-28-0
- Chemical Name
- Cevimeline Hydrochloride Salt
- Synonyms
- SNK 508;Fks 508;Snd 5008;Saligren;CeviMelin;rac-Cevimeline HCl;AF-102B hydrochloride;SNI-2011 hydrochloride;Cevimelin Hydrochloride;CEVIMELINE, HYDROCHLORIDE SALT
- CBNumber
- CB72130375
- Molecular Formula
- C10H18ClNOS
- Formula Weight
- 235.77402
- MOL File
- 107220-28-0.mol
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Cevimeline Hydrochloride Salt Property
- Melting point:
- 195-197?C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H
- InChIKey
- SURWTGAXEIEOGY-UHFFFAOYSA-N
- SMILES
- C1CC2C3(CSC(C)O3)CN1CC2.Cl
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Safety
- Toxicity
- mouse,LD50,intravenous,33mg/kg (33mg/kg),United States Patent Document. Vol. #4855290,
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17802
- Product name
- Cevimeline (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17802
- Product name
- Cevimeline (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $98
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17802
- Product name
- Cevimeline (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
TRC
- Product number
- C283500
- Product name
- rac,cis-CevimelineHydrochlorideSalt
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
TRC
- Product number
- C283500
- Product name
- rac,cis-CevimelineHydrochlorideSalt
- Packaging
- 25mg
- Price
- $335
- Updated
- 2021/12/16
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Cevimeline Hydrochloride Salt Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
A novel muscarinic M1 and M3 receptor agonist. Sialagogue.
Biological Activity
Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo .
in vivo
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].
| Animal Model: | Male Wistar rats (8-week-old) injected with angiotensin-II[1] |
| Dosage: | 0.008 mg/kg, 0.016 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. |
IC 50
mAChR1; mAChR3
storage
-20°C
Cevimeline Hydrochloride Salt Preparation Products And Raw materials
Raw materials
Preparation Products
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Cevimeline Hydrochloride Salt Suppliers
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View Lastest Price from Cevimeline Hydrochloride Salt manufacturers
HangZhou RunYan Pharma Technology Co.,LTD.
- Product
- Cevimeline HCl; Cevimeline;AF102B 107220-28-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%min. HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-09-10
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