(4-MORPHOLIN-4-YL-PHENYL)METHANOL

(4-MORPHOLIN-4-YL-PHENYL)METHANOL Property

Melting point:

96 °C

Boiling point:

378.4±42.0 °C(Predicted)

Density 

1.160±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

powder

pka

14.40±0.10(Predicted)

color 

White

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2934999090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(4-MORPHOLIN-4-YL-PHENYL)METHANOL Chemical Properties,Usage,Production

Synthesis

C. Synthesis of 4-(4-morpholinyl)benzyl alcohol. At -10 °C, 4-(4-morpholinyl)benzoic acid (1.00 g, 4.83 mmol) and 4-methylmorpholine (0.53 mL, 4.8 mmol) were dissolved in tetrahydrofuran (25 mL), followed by the addition of ethyl chloroformate (0.46 mL, 4.8 mmol). After 0.25 h of reaction, sodium borohydride (550 mg, 14.5 mmol) was added to the mixture followed by slow addition of methanol (50 mL). Next, the mixture was treated with 5% aqueous acetic acid, after which the mixture was concentrated. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to give 164 mg (18% yield) of 4-morpholinobenzyl alcohol. The product was characterized by 1H NMR, IR spectroscopy, field desorption mass spectrometry (FD-MS, m/e 193 (M+)), and elemental analysis (calculated values for C11H15NO2: C, 68.37; H, 7.82; N, 7.25; measured values: C, 68.46; H, 7.95; N, 7.21).

References

[1] Patent: US6610704, 2003, B1