Methyl 1-Boc-azetidine-3-carboxylate
- Product Name
- Methyl 1-Boc-azetidine-3-carboxylate
- CAS No.
- 610791-05-4
- Chemical Name
- Methyl 1-Boc-azetidine-3-carboxylate
- Synonyms
- 1-tert-butyl 3-methyl azetidine-1,3-dicarboxylate;AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER;N-Boc-3-a;3-dicarboxylate;1-Boc-azetidine-3-carboxyL;Methyl 1-Boc-azetidine-3-...;tert-butyl Methyl azetidine-1;Methyl Boc-Azetidine-3-carboxylate;methyl 1-Boc-3-azetidinecarboxylate;Methyl 1-Boc-azetidine-3-carboxylate
- CBNumber
- CB7216037
- Molecular Formula
- C10H17NO4
- Formula Weight
- 215.25
- MOL File
- 610791-05-4.mol
Methyl 1-Boc-azetidine-3-carboxylate Property
- Boiling point:
- 269.0±33.0 °C(Predicted)
- Density
- 1.072 g/mL at 25 °C
- refractive index
- n20/D1.452
- Flash point:
- >110℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- pka
- -2.97±0.40(Predicted)
- color
- Colorless to light yellow
- InChI
- InChI=1S/C10H17NO4/c1-10(2,3)15-9(13)11-5-7(6-11)8(12)14-4/h7H,5-6H2,1-4H3
- InChIKey
- SECFRXGVLMVUPD-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(C(OC)=O)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 792578
- Product name
- Methyl 1-Boc-azetidine-3-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $76.9
- Updated
- 2025/07/31
- Product number
- 792578
- Product name
- Methyl 1-Boc-azetidine-3-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- B5867
- Product name
- 1-tert-Butyl 3-Methyl Azetidine-1,3-dicarboxylate
- Purity
- min. 97.0 %
- Packaging
- 1G
- Price
- $40
- Updated
- 2025/07/31
- Product number
- B5867
- Product name
- 1-tert-Butyl 3-Methyl Azetidine-1,3-dicarboxylate
- Purity
- min. 97.0 %
- Packaging
- 5G
- Price
- $119
- Updated
- 2025/07/31
- Product number
- M295650
- Product name
- Methyl 1-Boc-azetidine-3-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
Methyl 1-Boc-azetidine-3-carboxylate Chemical Properties,Usage,Production
Uses
Building block used as a precursor to the synthesis of azaspiro[3.4]octanes developed in the Carreira group. This substrate can be readily functionalized via enolization at the 3-position in the presence of LDA.
Synthesis
67-56-1
142253-55-2
610791-05-4
General procedure for the synthesis of methyl 1-(tert-butoxycarbonyl)azetidine-3-carboxylate from methanol and 1-Boc-azetidine-3-carboxylic acid: 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid (AXL016917, 1000 mg, 4.97 mmol) was dissolved in a mixture of solvents with methanol (5 mL) and toluene (20 mL), and subsequently the solution was cooled to 0°C. Trimethylsilyl diazomethane (7.45 mmol) was slowly added dropwise over a period of 15 min, during which slight bubble production was observed. The color of the solution gradually changed from clear to light yellow. The reaction mixture was continued to be stirred at 0 °C for 10 min, followed by slow warming to room temperature over a period of 30 min. Upon completion of the reaction, toluene was removed by concentration and distillation under reduced pressure to afford 1.055 g of methyl 1-(tert-butoxycarbonyl)azetidine-3-carboxylate (99% crude yield), which could be used in the next step of the reaction without further purification.
IC 50
Non-cleavable Linker
References
[1] Patent: WO2006/21881, 2006, A2. Location in patent: Page/Page column 61
[2] Patent: WO2013/83991, 2013, A1. Location in patent: Page/Page column 69
[3] Patent: WO2012/142237, 2012, A1. Location in patent: Page/Page column 98-99
Methyl 1-Boc-azetidine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 1-Boc-azetidine-3-carboxylate manufacturers
- Product
- Methyl 1-Boc-azetidine-3-carboxylate 610791-05-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER 610791-05-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20