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Ethylenediaminetetraacetic acid tetrasodium salt

Description References
Product Name
Ethylenediaminetetraacetic acid tetrasodium salt
CAS No.
13235-36-4
Chemical Name
Ethylenediaminetetraacetic acid tetrasodium salt
Synonyms
1964-02-8;EDTA.Na.4H2O;TETRASODIUM ETHYLENEDIAMINETETRAACETATE TETRAHYDRATE;EDTA Na4 (Ethylene DiaMine Tetraacetic Acid TetrasodiuM);ETHYLENEDIAMINE TETRAACETIC ACID TETRASODIUM TETRAHYDRATE;ETHYLENEDIAMINETETRAACETIC ACID TETRASODIUM SALT HYDRATE SIGMAULTRA;Trilon B(EDTA-4Na);EDTA-4NA TETRAHYDRATE;EDTA 4NA Liquid 38% min;[ETHYLENEDINITRILO]TETRAACE
CBNumber
CB7222744
Molecular Formula
C10H19N2NaO9
Formula Weight
334.26
MOL File
13235-36-4.mol
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Ethylenediaminetetraacetic acid tetrasodium salt Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 0.1 M at 20 °C, clear, colorless
form 
Solid
color 
White crystalline
Odor
Odorless
Water Solubility 
almost transparency
InChI
InChI=1S/C10H16N2O8.Na.H2O.H/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;1H2;
InChIKey
LHCZUGDUAQREMU-UHFFFAOYSA-N
SMILES
N(CC(=O)O)(CC(=O)O)CCN(CC(=O)O)CC(=O)O.[NaH].O
CAS DataBase Reference
13235-36-4(CAS DataBase Reference)
EPA Substance Registry System
Tetrasodium ethylenediaminetetraacetate tetrahydrate (13235-36-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2922.49.8000
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E0565
Product name
Tetrasodium Ethylenediaminetetraacetate Tetrahydrate
Purity
>98.0%(T)
Packaging
25g
Price
$24
Updated
2026/04/30
TCI Chemical
Product number
E0565
Product name
Tetrasodium Ethylenediaminetetraacetate Tetrahydrate
Purity
>98.0%(T)
Packaging
500g
Price
$53
Updated
2026/04/30
GFS CHEMICALS
Product number
17793
Product name
TETRASODIUM ETHYLENEDIAMINETETRAACETATE TETRAHYDRATE, REAGENT
Packaging
2.5KG
Price
$215.99
Updated
2026/06/03
GFS CHEMICALS
Product number
17792
Product name
TETRASODIUM ETHYLENEDIAMINETETRAACETATE TETRAHYDRATE, REAGENT
Packaging
500G
Price
$82.22
Updated
2026/06/03
GFS CHEMICALS
Product number
17791
Product name
TETRASODIUM ETHYLENEDIAMINETETRAACETATE TETRAHYDRATE, REAGENT
Packaging
100G
Price
$37.95
Updated
2026/06/03
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Ethylenediaminetetraacetic acid tetrasodium salt Chemical Properties,Usage,Production

Description

Ethylenediaminetetraacetic acid tetrasodium salt (also named as sodium edetate) can be formed by reacting a basic solution of ethylenediamine with formaldehyde and sodium or hydrogen cyanide, followed by hydrolysis to form the salt. It can also be produced by using excess sodium hydroxide in the reaction.1 In medicine, sodium edetate is used a s chelating agent to remove heavy metal, such as lead or mercury, from the blood. It is used to lower blood levels of calcium, to control heart rhythm disturbances cased by a heart medication.2 In food industry, it is used as an additive in flume water for washing fruits and vegetables. In industry, it is used in the formulations of anti-adhesive agents, corrosion inhibitors, anti-scaling agents, lubricant additives, surface active agents, etc.3,4 It is also used in photo-chemicals, textile treatment products and dyes, biocides (e.g. disinfectants, pest control products) and polishes and waxes.5

References

  1. https://pubchem.ncbi.nlm.nih.gov/compound/16211056#section=Top
  2. https://www.drugs.com/mtm/edetate-disodium-edta.html
  3. http://www.efsa.europa.eu
  4. http://www.speiko.de 
https://echa.europa.eu/substance-information/-/substanceinfo/100.000.522

[1] Jae Hyeon Jo. (2019). New Insight into Ethylenediaminetetraacetic Acid Tetrasodium Salt as a Sacrificing Sodium Ion Source for Sodium-Deficient Cathode Materials for Full Cells. ACS Applied Materials & Interfaces, 11 6, 5957–5965. https://doi.org/10.1021/acsami.8b1848
[2] Kate McKey. (2025). Piloting 4% Tetrasodium Ethylenediaminetetraacetic Acid (T-EDTA) Catheter Lock Solution in Renal Hemodialysis: A Quality Improvement Evaluation. Journal of Infusion Nursing, 48 6, 412–421. https://doi.org/10.1097/NAN.0000000000000620
[3] Jocelyn Hill, Rachel G. (2021). Efficacy of 4% tetrasodium ethylenediaminetetraacetic acid (T-EDTA) catheter lock solution in home parenteral nutrition patients: A quality improvement evaluation. Journal of Vascular Access, 22 4, 533–539. https://doi.org/10.1177/1129729820946916

Uses

Ethylenediaminetetraacetic Acid Tetrasodium Salt is a chelator used to eliminate inhibition of enzyme catalyzed reactions. It can be used as reactant/reagent for green preparation of O-allylhydroxylamines via organocatalytic oxidation of tertiary allylic amines followed by a [2,3]-Meisenheimer rearrangement.

Application

Ethylenediaminetetraacetic acid tetrasodium salt (T-EDTA) can be used as a catheter locking solution for patients undergoing renal haemodialysis and those receiving home parenteral nutrition. A 4% T-EDTA catheter locking solution significantly reduces the risk of complications associated with central venous access devices, such as occlusion and catheter-related infections[2-3].

Biological Activity

Primary Target
H+-ATPase

Materials Uses

Ethylenediaminetetraacetic acid tetrasodium salt (EDTA-4Na) can serve as an additional source of Na⁺ ions, helping to increase the charge capacity[1].

Properties and Applications

INDEX/GRADE

SPECIFICATION

Appearance

White crystal powder

Purity

99% min

Chloride (Cl - )

0.01% max

Sulfate(SO4 2- )

0.05% max

Pb

0.001% max

Fe

0.001% max

Chelation value

220mg CaCO3/g min

pH value

10.5-11.5

NTA

1% max

Ethylenediaminetetraacetic acid tetrasodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethylenediaminetetraacetic acid tetrasodium salt Suppliers

Guangzhou Nalong Chemical Co.Ltd
Tel
13192879270; 13192879270
Email
1525037351@qq.com
Country
China
ProdList
3507
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58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44802
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 15618770481
Fax
021-64823266
Email
yhx@titansci.com
Country
China
ProdList
14100
Advantage
59
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7241
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from Ethylenediaminetetraacetic acid tetrasodium salt manufacturers

Shandong Yuanlian Chemical Co.,Ltd.
Product
Ethylene diamine tetraacetic acid tetrasodium salt,EDTA 4NA 13235-36-4
Price
US $0.00-0.00/kg
Min. Order
0.20000000298023224kg
Purity
≥99.0%
Supply Ability
10000 tons
Release date
2026-03-19
Qingdao Trust Agri Chemical Co.,Ltd
Product
EDTA-4Na 13235-36-4
Price
US $0.00/KG
Min. Order
1000KG
Purity
99.5
Supply Ability
200TONS/MONTH
Release date
2025-09-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
EDTA-4NA 13235-36-4
Price
US $0.00-0.00/Kg/Bag
Min. Order
1KG
Purity
99.0%min
Supply Ability
20 tons
Release date
2021-07-23

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