ChemicalBook > CAS DataBase List > Spermidine trihydrochloride

Spermidine trihydrochloride

Product Name
Spermidine trihydrochloride
CAS No.
334-50-9
Chemical Name
Spermidine trihydrochloride
Synonyms
SPERMIDINE HCl;Spermidie 3HCL;SPERMIDINE HYDROCHLORIDE;SperMidine tri;SPERMIDINE 3HCL;SPERMIDINE 3HC;Spermidine 3HCl>98%;Spermidine·3hydrochloride;SPERMIDINE TRIHYDROCHLORIDE;SPERMIDINE.3HCLRESEARCH GRADE
CBNumber
CB7223105
Molecular Formula
C7H22Cl3N3
Formula Weight
254.63
MOL File
334-50-9.mol
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Spermidine trihydrochloride Property

Melting point:
257-259 °C(lit.)
storage temp. 
room temp
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Crystalline Powder
color 
White
PH
3.0-6.0 (25℃, 1M in H2O)
Water Solubility 
Soluble in water (100 mg/ml), and ethanol.
λmax
λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.1
BRN 
3552356
InChI
InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
InChIKey
LCNBIHVSOPXFMR-UHFFFAOYSA-N
SMILES
C(CCCN)NCCCN.Cl.Cl.Cl
CAS DataBase Reference
334-50-9(CAS DataBase Reference)
EPA Substance Registry System
1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
EJ7023000
F 
3-10
TSCA 
Yes
HS Code 
29212900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
85578
Product name
Spermidine trihydrochloride
Purity
BioXtra, ≥99.5% (AT)
Packaging
1g
Price
$61.2
Updated
2024/03/01
Sigma-Aldrich
Product number
56766-M
Product name
Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem
Purity
Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.
Packaging
5G
Price
$259
Updated
2024/03/01
Alfa Aesar
Product number
J61595
Product name
Spermidine trihydrochloride, 99+%
Packaging
100mg
Price
$66.65
Updated
2024/03/01
Sigma-Aldrich
Product number
S2501
Product name
Spermidine trihydrochloride
Purity
≥98% (TLC)
Packaging
1g
Price
$42.7
Updated
2024/03/01
Sigma-Aldrich
Product number
S2501
Product name
Spermidine trihydrochloride
Purity
≥98% (TLC)
Packaging
5g
Price
$138
Updated
2024/03/01
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Spermidine trihydrochloride Chemical Properties,Usage,Production

Description

Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.

Chemical Properties

Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.

Chemical Reactivity

Spermidine hydrochloride is a white crystal at normal temperature and pressure. It is the hydrochloride form of spermidine.When it is used, it is often reacted with alkali to release a triamine structure.

Uses

Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.

Definition

Spermidine trihydrochloride powder is the trihydrochloride form of spermidine. Spermidine base is in liquid form, while Spermidine trihydrochloride is in powder form. Spermidine trihydrochloride is a more stable form because spermidine is very air-sensitive. Spermidine trihydrochloride powder benefits are the same as Spermidine benefits.

benefits

Spermidine trihydrochloride has been extensively studied for its potential health benefits, including its ability to modulate autophagy, enhance cardiovascular health, protect against neurodegenerative diseases, and exhibit antioxidant activity. Studies have shown that it can enhance cardiovascular health by promoting blood vessel relaxation, reducing oxidative stress, and improving mitochondrial function. It has also been suggested to have neuroprotective effects and may contribute to cognitive health and brain function. It has shown promising results in preclinical studies, demonstrating its ability to protect neurons, reduce inflammation, and enhance cellular resilience.

Biological Functions

Spermidine inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.

General Description

Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.

Biological Activity

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801.
Spermidine trihydrochloride is an aliphatic polyamine. Its crystalline structure has been studied. It has been reported to preserve the nuclei and prevent proteolytic degradation of histones during the macronuclei isolation from Tetrahymena pyriformis.

storage

+4°C (desiccate)

Purification Methods

Recrystallise the salt from dry 3% HCl in ethanol and adding dry Et2O if necessary. Filter it off rapidly and dry it in a vacuum desiccator. Alternatively centrifuge the crystals off, wash them with dry Et2O and dry them in a vacuum. [Beilstein 4 IV 1300.]

Spermidine trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Spermidine trihydrochloride manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Spermidine trihydrochloride 334-50-9
Price
US $0.00-0.00/g
Min. Order
10000g
Purity
99% HPLC
Supply Ability
1000kg
Release date
2024-11-23
CONTIDE BIOTECH CO.,LTD
Product
Spermidine trihydrochloride 34-50-9
Price
US $0.00/G
Min. Order
1G
Purity
99
Supply Ability
20
Release date
2024-04-11
Jinan Million Pharmaceutical Co., Ltd
Product
Spermidine trihydrochloride 334-50-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99.45
Supply Ability
60 tons
Release date
2024-08-30

334-50-9, Spermidine trihydrochlorideRelated Search:

Spermidine L-701,252 O,O-Dimethyl phosphoramidothioate GUSPERIMUS 3HCL SPERMINE TETRAHYDROCHLORIDE Spermidine trihydrochloride SPERMINE TETRAHYDROCHLORIDE, [TERMINAL METHYLENE-3H] N1-ACETYLSPERMINE TRIHYDROCHLORIDE [(1'-BENZYL-1,4'-BIPIPERIDIN-4-YL)METHYL]AMINETRIHYDROCHLORIDE 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE N1,N12-DIETHYLSPERMINE TETRAHYDROCHLORIDE N-(4-HYDROXYPHENYLPROPANOYL) SPERMINE TRIHYDROCHLORIDE 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride [14C]SPERMINE TETRAHYDROCHLORIDE [14C]SPERMIDINE TRIHYDROCHLORIDE [(1'-METHYL-1,4'-BIPIPERIDIN-4-YL)METHYL]-(PYRIDIN-4-YLMETHYL)AMINE TETRAHYDROCHLORIDE SPERMIDINE TRIHYDROCHLORIDE, TERMINAL METHYLENES-3H(N)]- SPERMIDINE-8-14C TRIHYDROCHLORIDE

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