Benzofuran-5-carboxylic acid
- Product Name
- Benzofuran-5-carboxylic acid
- CAS No.
- 90721-27-0
- Chemical Name
- Benzofuran-5-carboxylic acid
- Synonyms
- RARECHEM AL BE 1369;5-Benzofurancarboxylic acid;Benzofuran-5-carboxylic acid;1-benzofunan-5-carboxylic acid;1-BENZOFURAN-5-CARBOXYLIC ACID;Benzo[b]furan-5-carboxylic acid;3a,7a-dihydrobenzofuran-5-carboxylic acid;1-Benzofuran-5-carboxylic acid, 5-Carboxybenzo[b]furan
- CBNumber
- CB7224021
- Molecular Formula
- C9H6O3
- Formula Weight
- 162.14
- MOL File
- 90721-27-0.mol
Benzofuran-5-carboxylic acid Property
- Melting point:
- 189-190°C
- Boiling point:
- 325.6±15.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 4.06±0.30(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C9H6O3/c10-9(11)7-1-2-8-6(5-7)3-4-12-8/h1-5H,(H,10,11)
- InChIKey
- GTWXSZIQNTUNKR-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(C(O)=O)C=C2C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B207738
- Product name
- 1-Benzofuran-5-carboxylicacid
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB142796
- Product name
- Benzofuran-5-carboxylic acid
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- Y4644
- Product name
- 1-Benzofuran-5-carboxylicacid
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
- Product number
- 100717
- Product name
- 1-Benzofuran-5-carboxylic acid
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
- Product number
- FB142796
- Product name
- Benzofuran-5-carboxylic acid
- Packaging
- 2g
- Price
- $181
- Updated
- 2021/12/16
Benzofuran-5-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Synthesis
108763-47-9
90721-27-0
General procedure for the synthesis of 1-benzofuran-5-carboxylic acid from methyl benzofuran-5-carboxylate: Methyl benzofuran-5-carboxylate (1.3 g, 7.38 mmol) was dissolved in methanol (51 mL), 5% aqueous sodium hydroxide solution (41 mL) was added, and the mixture was stirred. The reaction mixture was heated to 65 °C and kept at this temperature for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and the methanol was removed by distillation under reduced pressure. The remaining aqueous phase was extracted with dichloromethane and the organic phase was discarded. The aqueous phase was acidified with concentrated hydrochloric acid to pH=1 and then extracted with chloroform. The organic phases were combined, washed with deionized water, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 1.2 g (98% yield) of 1-benzofuran-5-carboxylic acid as a white solid.1H NMR (400 MHz, DMSO-d6) δ 12.9, 8.30, 8.11, 7.92, 7.69, 7.09.
References
[1] Patent: US2003/232853, 2003, A1. Location in patent: Page 37
[2] Patent: WO2004/39815, 2004, A2. Location in patent: Page 70
[3] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0182
[4] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1797 - 1809
[5] Journal of Medicinal Chemistry, 1995, vol. 38, # 16, p. 3094 - 3105
Benzofuran-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Benzofuran-5-carboxylic acid Suppliers
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- Country
- Belgium
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- 6293
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View Lastest Price from Benzofuran-5-carboxylic acid manufacturers
- Product
- Benzofuran-5-carboxylic acid 90721-27-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-23
- Product
- Benzofuran-5-carboxylic acid 90721-27-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-18