METHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE

METHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE Property

Boiling point:

211℃

Density 

1.24

refractive index 

1.45-1.452

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

color 

Clear colorless

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

HazardClass 

IRRITANT

HS Code 

29163900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

METHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Synthesis

Concentrated sulfuric acid (50 mL) was added slowly to a solution of methanol (1200 mL) of m-trifluoromethylphenylacetic acid (1.0 mol). The reaction mixture was heated to reflux and the reaction was stirred overnight. Upon completion of the reaction, the reaction solution was concentrated to dryness under reduced pressure. Water (600 mL) was added to the residue and extracted with ethyl acetate (3 x 400 mL). The organic layers were combined and washed with water until neutral. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by column chromatography (eluent: ethyl acetate/petroleum ether=1:20) to afford methyl 3-trifluoromethylphenylacetate (108 g, 100% yield) as a yellow oil.

References

[1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 13, p. 2843 - 2866
[2] Patent: US2005/234046, 2005, A1. Location in patent: Page/Page column 97
[3] Helvetica Chimica Acta, 1971, vol. 54, p. 868 - 897
[4] Tetrahedron Letters, 2018, vol. 59, # 22, p. 2161 - 2166
[5] Patent: US2479295, 1946,