Tegaserod maleate
- Product Name
- Tegaserod maleate
- CAS No.
- 189188-57-6
- Chemical Name
- Tegaserod maleate
- Synonyms
- ZELMAC;HTF 919;ZelnorM;Tegibs 6;Toromifene;SDZ-HTF-919;TegaserodMalate;TegastrodMaleate;TEGASEROD MALEATE;Tegaserol Maleate
- CBNumber
- CB7225422
- Molecular Formula
- C20H27N5O5
- Formula Weight
- 417.46
- MOL File
- 189188-57-6.mol
Tegaserod maleate Property
- Melting point:
- 180-183°C
- storage temp.
- 2-8°C
- solubility
- Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Sparingly)
- form
- powder
- color
- white to beige
- CAS DataBase Reference
- 189188-57-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1504
- Product name
- Tegaserod maleate
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $120
- Updated
- 2024/03/01
- Product number
- SML1504
- Product name
- Tegaserod maleate
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $490
- Updated
- 2024/03/01
- Product number
- 14692
- Product name
- Tegaserod (maleate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 14692
- Product name
- Tegaserod (maleate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 14692
- Product name
- Tegaserod (maleate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $217
- Updated
- 2024/03/01
Tegaserod maleate Chemical Properties,Usage,Production
Description
Tegaserod maleate was launched as a new oral treatment of constipationpredominant or diarrhea-predominant irritable bowel syndrome. It can be prepared by condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine. Tegaserod is a selective partial agonist of the excitatory 5-HT4 receptor (K1 = 18 nM in human caudate membranes) and was designed from the endogenous full agonist, seretonin. In the model of potentiation of the electrically stimulated contraction of longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic activity compared with serotonin. However, it appeared more potent in several studies on intestinal mucosal tissue from various species including man. A lack of effect on the QTc interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also clinically developed for the treatment of other functional GI disorders such as functional dyspepsia and gastroesophageal reflux disease (GERD).
Chemical Properties
White Powder
Originator
Novartis (Switzerland)
Uses
Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.
Uses
Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.
brand name
Zelnorm (Novartis);Zelmac.
Biochem/physiol Actions
It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.
storage
+4°C
Tegaserod maleate Preparation Products And Raw materials
Raw materials
Preparation Products
Tegaserod maleate Suppliers
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View Lastest Price from Tegaserod maleate manufacturers
- Product
- Tegaserod maleate 189188-57-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Ton
- Release date
- 2022-10-10
- Product
- Tegaserod maleate 189188-57-6
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-06
- Product
- Tegaserod maleate 189188-57-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-07-27