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Tegaserod maleate

Product Name
Tegaserod maleate
CAS No.
189188-57-6
Chemical Name
Tegaserod maleate
Synonyms
ZELMAC;HTF 919;ZelnorM;Tegibs 6;Toromifene;SDZ-HTF-919;TegaserodMalate;TegastrodMaleate;TEGASEROD MALEATE;Tegaserol Maleate
CBNumber
CB7225422
Molecular Formula
C20H27N5O5
Formula Weight
417.46
MOL File
189188-57-6.mol
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Tegaserod maleate Property

Melting point:
180-183°C
storage temp. 
2-8°C
solubility 
Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Sparingly)
form 
powder
color 
white to beige
CAS DataBase Reference
189188-57-6(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1504
Product name
Tegaserod maleate
Purity
≥98% (HPLC)
Packaging
10MG
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1504
Product name
Tegaserod maleate
Purity
≥98% (HPLC)
Packaging
50MG
Price
$490
Updated
2024/03/01
Cayman Chemical
Product number
14692
Product name
Tegaserod (maleate)
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
14692
Product name
Tegaserod (maleate)
Purity
≥98%
Packaging
10mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
14692
Product name
Tegaserod (maleate)
Purity
≥98%
Packaging
25mg
Price
$217
Updated
2024/03/01
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Tegaserod maleate Chemical Properties,Usage,Production

Description

Tegaserod maleate was launched as a new oral treatment of constipationpredominant or diarrhea-predominant irritable bowel syndrome. It can be prepared by condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine. Tegaserod is a selective partial agonist of the excitatory 5-HT4 receptor (K1 = 18 nM in human caudate membranes) and was designed from the endogenous full agonist, seretonin. In the model of potentiation of the electrically stimulated contraction of longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic activity compared with serotonin. However, it appeared more potent in several studies on intestinal mucosal tissue from various species including man. A lack of effect on the QTc interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also clinically developed for the treatment of other functional GI disorders such as functional dyspepsia and gastroesophageal reflux disease (GERD).

Chemical Properties

White Powder

Originator

Novartis (Switzerland)

Uses

Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.

Uses

Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.

brand name

Zelnorm (Novartis);Zelmac.

Biochem/physiol Actions

It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.

storage

+4°C

Tegaserod maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tegaserod maleate Suppliers

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View Lastest Price from Tegaserod maleate manufacturers

Hebei Duling International Trade Co. LTD
Product
Tegaserod maleate 189188-57-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Ton
Release date
2022-10-10
Shaanxi Dideu Medichem Co. Ltd
Product
Tegaserod maleate 189188-57-6
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-06
Henan Bao Enluo International TradeCo.，LTD
Product
Tegaserod maleate 189188-57-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-07-27

189188-57-6, Tegaserod maleateRelated Search:

Tegaserod Hydrogen Sulfide Indole Hydrogen 4,4'-Diphenylmethane diisocyanate Bis(2-ethylhexyl) maleate Maleic acid Cinepazide maleate Enalapril maleate Chlorphenamine maleate Trimebutine maleate Methylene Blue Disodium fumarate Methylene Chloride HYDROGEN CYANIDE Hydrogen peroxide N-PENTYL-N-AMINOGAUNIDINE HYDROIODIN ( FOR TEGASEROD MALEATE ) Tegaserod maleate

  • SDZ-HTF-919
  • TEGASEROD MALEATE
  • ZELMAC
  • 2-[(5-METHOXY-1H-INDOL-3-YL)METHYLENE]-N-PENTYLHYDRAZINECARBOXIMIDAMIDE, MALEATE
  • 2-[(5-methoxy-1h-indole-3-yl)methylene]-n-pentylcarbazimidamide hydrogen maleate
  • TegaserodMalate
  • TegastrodMaleate
  • SDZ-HTF-919, Zelmac, 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide, Maleate
  • Toromifene
  • Tegaserod Hydrogen Maleate
  • 2-[(5-Methoxy-1H-indol-3-yl)Methylene]-N-pentylhydrazinecarboxiMidaMide (2Z)-2-Butenedioate
  • HTF 919
  • Tegibs 6
  • ZelnorM
  • 1-[(5-methoxy-3-indolylidene)methylamino]-2-pentylguanidine
  • ZELNORM;SDZ-HTF-919;HTF-919;ZELMAC
  • Tegaserol Maleate
  • Tegaserod maleate USP/EP/BP
  • Tegaserod maleateQ: What is Tegaserod maleate Q: What is the CAS Number of Tegaserod maleate Q: What is the storage condition of Tegaserod maleate Q: What are the applications of Tegaserod maleate
  • Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1)
  • 2-((5-Methoxy-1H-indol-3-yl)methylene)-N-pentylhydrazine-1-carboximidamide maleate
  • 189188-57-6
  • C16H23ON5C4H4O4
  • C16H23N5OC4H4O4C20H27N5O5
  • C16H23N5OC4H4O4
  • C20H27N5O5
  • C16H23N5OC4H4O4C20H
  • Chiral Compound
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Tegaserod
  • Active Pharmaceutical Ingredients