ChemicalBook > CAS DataBase List > FMOC-NLE-OH

FMOC-NLE-OH

Product Name: FMOC-NLE-OH
CAS No.: 77284-32-3
Chemical Name: FMOC-NLE-OH
Synonyms: FMOC-NLE;FMOC-NLE-OH;FMOC-L-NLE-OH;FMOC-AHX(2)-OH;FMOC-NORLEUCINE;FMOC-ACPO(2)-OH;FMOC-NLE-OH 98+%;FMOC-L-NORLEUCINE;RARECHEM EM WB 0166;N-FMOC-L-NORLEUCINE
CBNumber: CB7225457
Molecular Formula: C21H23NO4
Formula Weight: 353.41
MOL File: 77284-32-3.mol

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FMOC-NLE-OH Property

Melting point:: 141-144 °C(lit.)
alpha: -18.5 º (C=1 IN DMF)
Boiling point:: 565.6±33.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.91±0.21(Predicted)
form: Crystalline Powder
color: White to off-white
optical activity: [α]20/D 18±1°, c = 1% in DMF
BRN: 5305164
CAS DataBase Reference: 77284-32-3(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52014
Product name: Fmoc-Nle-OH
Purity: Novabiochem?
Packaging: 5G
Price: $95.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52014
Product name: Fmoc-Nle-OH
Purity: Novabiochem?
Packaging: 25g
Price: $360
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52014
Product name: Fmoc-Nle-OH
Purity: Novabiochem®
Packaging: 100 g
Price: $1110
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52014
Product name: Fmoc-Nle-OH
Purity: Novabiochem®
Packaging: 100 g
Price: $1110
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52014
Product name: Fmoc-Nle-OH
Purity: Novabiochem®
Packaging: 1 kg
Price: $10130
Updated: 2025/07/31

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FMOC-NLE-OH Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

Fmoc-Nle-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

947154-63-4

77284-32-3

V-Fmoc allylglycine (100 mg, 0.296 mmol), degassed dichloromethane (6.0 mL), terminal olefins (1.48 mmol, 5 eq.), and HGII catalyst (9.29 mg, 5 mol%) were added to a Schlenk reaction flask equipped with a magnetic stirring bar in a drying oven under nitrogen atmosphere. After sealing the reaction flask, it was removed from the desiccator and connected to a vacuum system. The reaction vial was placed under a stream of nitrogen and the quick assembly stopper was replaced with a sub-seal with a 26-gauge pinhole to ensure a continuous flow of nitrogen across the top of the reaction system. The reaction mixture was stirred overnight at room temperature, followed by evaporation of all dichloromethane. The residue was washed with hexane (2 x 10 mL) and collected by filtration or centrifugation. The resulting residue was redissolved in methanol (10 mL) and transferred to a Fischer-Porter reaction tube. The reaction tube was filled with hydrogen (60 psi), sealed and stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum and the residual brown solid was purified by column chromatography to give the pure Fmoc amino acid analog. Alternatively, the residual brown solid is dissolved in a small amount of ether, the insoluble material is removed by filtration, and the filtrate is concentrated under vacuum to give an off-white solid.

References

[1] Journal of Peptide Science, 2013, vol. 19, # 8, p. 470 - 476
[2] Patent: WO2014/5197, 2014, A1. Location in patent: Page/Page column 48-49

FMOC-NLE-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-NLE-OH Suppliers

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View Lastest Price from FMOC-NLE-OH manufacturers

Career Henan Chemical Co

Product: FMOC-NLE-OH 77284-32-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

Career Henan Chemical Co

Product: FMOC-NLE-OH 77284-32-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

77284-32-3, FMOC-NLE-OHRelated Search:

FMOC-CHA-OH FMOC-CHG-OH FMOC-L-HOMOPHENYLALANINE Fmoc-THr(Bzl)-OH Fmoc-D-Asp(OtBu)-OH N-FMoc-L-norvaline Fmoc-L-aspartic acid 4-benzyl ester Fmoc-S-acetamidomethyl-L-cysteine FMOC-D-CHA-OH FMOC-ASP(OCHEX)-OH FMOC-SARCOSINE MONOHYDRATE Fmoc-O-tert-butyl-D-threonine FMOC-D-4-IODOPHENYLALANINE L-Fmoc-Aspartic acid alpha-tert-butyl ester FMOC-HOMOARG-OH 9-Fluorenylmethyl carbamate FMOC-6-AMINOHEXANOIC ACID FMOC-D-NLE-OH

N-(9-Fluorenylmethoxycarbonyl)-Lnorleucine, Fmoc-L-norleucine

Fmoc-Nle-OH >=98.0% (sum of enantiomers, HPLC)

(9H-Fluoren-9-yl)MethOxy]Carbonyl L-Nle-OH

Fmoc-L-norleucine≥ 99% (HPLC)

(S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-HEXANOIC ACID

(S)-2-(FMOC-AMINO)HEXANOIC ACID

(S)-2-(FMOC-AMINO)CAPROIC ACID

(S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID

RARECHEM EM WB 0166

N-ALPHA-FMOC-L-NORLEUCINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-NORLEUCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-NORLEUCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINOCAPROIC ACID

N-(9-FLUORENYLMETHOXYCARBONYL)-L-NORLEUCINE

N-FMOC-L-NORLEUCINE

N-(9-FLUORENYLMETHOXYCARBONYL)-L- &

FMOC-NLE-OH 98+%

FMOC-NLE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-NORLEUCINE, (S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID

FMOC-NLE-OH

FMOC-NORLEUCINE

FMOC-L-2-AMINOCAPROIC ACID

FMOC-L-2-AMINOHEXANOIC ACID

FMOC-L-NLE-OH

FMOC-L-NORLEUCINE

FMOC-L-NHCH[CH3(CH2)3]-COOH

FMOC-ACPO(2)-OH

FMOC-AHX(2)-OH

Fmoc-Nle-OH (Fmoc-L-norleucine

FMOC-L-NORLEUCINE extrapure

(9-fluorenylmethoxycarbonyl)-L-norleucine-OH

(S)-2-(Fmoc-amino)caproic acid, (S)-2-(Fmoc-amino)hexanoic acid, N-(9-Fluorenylmethoxycarbonyl)-L-norleucine, Fmoc-L-norleucine

(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)hexanoic acid

Fmoc-(S)-2-aminohexanoicacid

2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]hexanoate

L-Norleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

FMOC-NLE-OH USP/EP/BP

(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoate

Fmoc-L-2-aminocaproic acid - 10 g

Fmoc-Nle-OH,?97%min

77284-32-3

Norleucine

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Unusual Amino Acids

Amino Acid Derivatives

Amino Acids