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FMOC-NLE-OH

Product Name
FMOC-NLE-OH
CAS No.
77284-32-3
Chemical Name
FMOC-NLE-OH
Synonyms
FMOC-NLE;FMOC-NLE-OH;FMOC-L-NLE-OH;FMOC-AHX(2)-OH;FMOC-NORLEUCINE;FMOC-ACPO(2)-OH;FMOC-NLE-OH 98+%;FMOC-L-NORLEUCINE;RARECHEM EM WB 0166;N-FMOC-L-NORLEUCINE
CBNumber
CB7225457
Molecular Formula
C21H23NO4
Formula Weight
353.41
MOL File
77284-32-3.mol
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FMOC-NLE-OH Property

Melting point:
141-144 °C(lit.)
alpha 
-18.5 º (C=1 IN DMF)
Boiling point:
565.6±33.0 °C(Predicted)
Density 
1.209±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.91±0.21(Predicted)
form 
Crystalline Powder
color 
White to off-white
optical activity
[α]20/D 18±1°, c = 1% in DMF
BRN 
5305164
CAS DataBase Reference
77284-32-3(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2924 29 70
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52014
Product name
Fmoc-Nle-OH
Purity
Novabiochem?
Packaging
5G
Price
$95.9
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52014
Product name
Fmoc-Nle-OH
Purity
Novabiochem?
Packaging
25g
Price
$360
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52014
Product name
Fmoc-Nle-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
100 g
Price
$1110
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52014
Product name
Fmoc-Nle-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
100 g
Price
$1110
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52014
Product name
Fmoc-Nle-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$10130
Updated
2025/07/31
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FMOC-NLE-OH Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

Fmoc-Nle-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

947154-63-4

77284-32-3

V-Fmoc allylglycine (100 mg, 0.296 mmol), degassed dichloromethane (6.0 mL), terminal olefins (1.48 mmol, 5 eq.), and HGII catalyst (9.29 mg, 5 mol%) were added to a Schlenk reaction flask equipped with a magnetic stirring bar in a drying oven under nitrogen atmosphere. After sealing the reaction flask, it was removed from the desiccator and connected to a vacuum system. The reaction vial was placed under a stream of nitrogen and the quick assembly stopper was replaced with a sub-seal with a 26-gauge pinhole to ensure a continuous flow of nitrogen across the top of the reaction system. The reaction mixture was stirred overnight at room temperature, followed by evaporation of all dichloromethane. The residue was washed with hexane (2 x 10 mL) and collected by filtration or centrifugation. The resulting residue was redissolved in methanol (10 mL) and transferred to a Fischer-Porter reaction tube. The reaction tube was filled with hydrogen (60 psi), sealed and stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum and the residual brown solid was purified by column chromatography to give the pure Fmoc amino acid analog. Alternatively, the residual brown solid is dissolved in a small amount of ether, the insoluble material is removed by filtration, and the filtrate is concentrated under vacuum to give an off-white solid.

References

[1] Journal of Peptide Science, 2013, vol. 19, # 8, p. 470 - 476
[2] Patent: WO2014/5197, 2014, A1. Location in patent: Page/Page column 48-49

FMOC-NLE-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-NLE-OH Suppliers

China 212 France 1 Germany 7 India 9 Japan 4 Switzerland 6 United Kingdom 5 United States 39 Global 283
Christof Senn Laboratories AG
Tel
--
Fax
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Email
christof.senn@cslabs.ch
Country
Switzerland
ProdList
502
Advantage
58
ASCHEM GmbH
Tel
--
Fax
--
Email
info@aschem.ch
Country
Switzerland
ProdList
897
Advantage
58
Bachem AG
Tel
--
Fax
--
Email
sales.ch@bachem.com
Country
Switzerland
ProdList
438
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Alexis Corporation
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
Senn Chemicals AG
Tel
--
Fax
--
Email
swiss@sennchem.com
Country
Switzerland
ProdList
3143
Advantage
71
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View Lastest Price from FMOC-NLE-OH manufacturers

Career Henan Chemical Co
Product
FMOC-NLE-OH 77284-32-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15
Career Henan Chemical Co
Product
FMOC-NLE-OH 77284-32-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

77284-32-3, FMOC-NLE-OHRelated Search:

FMOC-CHA-OH FMOC-CHG-OH FMOC-L-HOMOPHENYLALANINE Fmoc-THr(Bzl)-OH Fmoc-D-Asp(OtBu)-OH N-FMoc-L-norvaline Fmoc-L-aspartic acid 4-benzyl ester Fmoc-S-acetamidomethyl-L-cysteine FMOC-D-CHA-OH FMOC-ASP(OCHEX)-OH FMOC-SARCOSINE MONOHYDRATE Fmoc-O-tert-butyl-D-threonine FMOC-D-4-IODOPHENYLALANINE L-Fmoc-Aspartic acid alpha-tert-butyl ester FMOC-HOMOARG-OH 9-Fluorenylmethyl carbamate FMOC-6-AMINOHEXANOIC ACID FMOC-D-NLE-OH

  • N-(9-Fluorenylmethoxycarbonyl)-Lnorleucine, Fmoc-L-norleucine
  • Fmoc-Nle-OH >=98.0% (sum of enantiomers, HPLC)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl L-Nle-OH
  • Fmoc-L-norleucine≥ 99% (HPLC)
  • (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-HEXANOIC ACID
  • (S)-2-(FMOC-AMINO)HEXANOIC ACID
  • (S)-2-(FMOC-AMINO)CAPROIC ACID
  • (S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID
  • RARECHEM EM WB 0166
  • N-ALPHA-FMOC-L-NORLEUCINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-NORLEUCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-NORLEUCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINOCAPROIC ACID
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-NORLEUCINE
  • N-FMOC-L-NORLEUCINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L- &
  • FMOC-NLE-OH 98+%
  • FMOC-NLE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-NORLEUCINE, (S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID
  • FMOC-NLE-OH
  • FMOC-NORLEUCINE
  • FMOC-L-2-AMINOCAPROIC ACID
  • FMOC-L-2-AMINOHEXANOIC ACID
  • FMOC-L-NLE-OH
  • FMOC-L-NORLEUCINE
  • FMOC-L-NHCH[CH3(CH2)3]-COOH
  • FMOC-ACPO(2)-OH
  • FMOC-AHX(2)-OH
  • Fmoc-Nle-OH (Fmoc-L-norleucine
  • FMOC-L-NORLEUCINE extrapure
  • (9-fluorenylmethoxycarbonyl)-L-norleucine-OH
  • (S)-2-(Fmoc-amino)caproic acid, (S)-2-(Fmoc-amino)hexanoic acid, N-(9-Fluorenylmethoxycarbonyl)-L-norleucine, Fmoc-L-norleucine
  • (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)hexanoic acid
  • Fmoc-(S)-2-aminohexanoicacid
  • 2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]hexanoate
  • L-Norleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • FMOC-NLE-OH USP/EP/BP
  • (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoate
  • Fmoc-L-2-aminocaproic acid - 10 g
  • Fmoc-Nle-OH,?97%min
  • 77284-32-3
  • Norleucine
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Unusual Amino Acids
  • Amino Acid Derivatives
  • Amino Acids