FMOC-6-AMINOHEXANOIC ACID

Product Name: FMOC-6-AMINOHEXANOIC ACID
CAS No.: 88574-06-5
Chemical Name: FMOC-6-AMINOHEXANOIC ACID
Synonyms: Fmoc-6-Aca;FMOC-ACP-OH;FMOC-6-AHX-OH;FMOC-6-ACA-OH;Fmoc-e-Acp-OH;FMOC-ACP(6)-OH;FMOC-AHX(6)-OH;FMOC-EPSILON-AHX-OH;FMOC-NH-(CH2)5-COOH;FMOC-EPSILON-ACP-OH
CBNumber: CB7388293
Molecular Formula: C21H23NO4
Formula Weight: 353.41
MOL File: 88574-06-5.mol

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FMOC-6-AMINOHEXANOIC ACID Property

Melting point:: 114 °C
Boiling point:: 582.7±33.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in water or 1% acetic acid
form: Powder
pka: 4.75±0.10(Predicted)
color: White
Water Solubility: Soluble in 1% acetic acid, water and 1mmol in 2mL DMF clearly soluble.
BRN: 5883220
CAS DataBase Reference: 88574-06-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52053
Product name: Fmoc-ε-Ahx-OH
Purity: Novabiochem?
Packaging: 1g
Price: $48.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52053
Product name: Fmoc-ε-Ahx-OH
Purity: Novabiochem?
Packaging: 5G
Price: $173
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52053
Product name: Fmoc-ε-Ahx-OH
Purity: Novabiochem?
Packaging: 25g
Price: $343
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52053
Product name: Fmoc-ε-Ahx-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 100 g
Price: $940
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52053
Product name: Fmoc-ε-Ahx-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 100 g
Price: $940
Updated: 2025/07/31

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FMOC-6-AMINOHEXANOIC ACID Chemical Properties,Usage,Production

Description

Fmoc-6-aminohexanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-6-aminohexanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White powder

Uses

Fmoc-6-aminohexanoic acid, is an amino acid derivative used in chemical synthesis and peptide chemistry.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

82911-69-1

60-32-2

88574-06-5

GENERAL STEPS: 389 mg (2.96 mmol) of 6-aminohexanoic acid was dissolved in 20 mL of a solvent mixture of acetone/water (1:1, v/v), 1.00 g (2.96 mmol) of 9-fluorenylmethyl-N-succinimidyl carbonate (FmocOSuc) and 250 mg (2.96 mmol) of sodium bicarbonate (NaHCO3) were added. The reaction suspension was stirred at room temperature for 3 hours. After completion of the reaction, acetone was removed by distillation under reduced pressure and 20 mL of dichloromethane (DCM) was added to the residue. Insoluble solids were removed by filtration. The organic phase was washed sequentially with 10 mL of 0.1 M hydrochloric acid (HCl) and 10 mL of water. The washed organic phase was dried with anhydrous sodium sulfate (Na2SO4), concentrated under reduced pressure to remove the solvent, and the residue was dried under vacuum to give 747 mg (71% yield) of the target product Fmoc-6-aminohexanoic acid as a colorless solid.

References

[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 39, p. 7139 - 7142
[2] Helvetica Chimica Acta, 1997, vol. 80, # 4, p. 1061 - 1072
[3] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 493 - 498
[4] Bioconjugate Chemistry, 2018, vol. 29, # 9, p. 2909 - 2919
[5] Analytical Chemistry, 2005, vol. 77, # 10, p. 3301 - 3308

FMOC-6-AMINOHEXANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-6-AMINOHEXANOIC ACID Suppliers

China 186 France 1 Germany 4 India 5 Japan 4 Switzerland 2 United Kingdom 3 United States 28 Global 233

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View Lastest Price from FMOC-6-AMINOHEXANOIC ACID manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: FMOC-6-AMINOHEXANOIC ACID 88574-06-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-04-27

Hangzhou ICH Biofarm Co., Ltd

Product: Fmoc-6-Aminohexanoic acid 88574-06-5
Price: US $0.00/Box
Min. Order: 1Box
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-26

Career Henan Chemical Co

Product: FMOC-6-AMINOHEXANOIC ACID 88574-06-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

88574-06-5, FMOC-6-AMINOHEXANOIC ACIDRelated Search:

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-NORLEUCINE, (S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID,(S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID N-FMoc-L-norvaline FMOC-ABU-OH FMOC-D-CHA-OH FMOC-SARCOSINE MONOHYDRATE FMOC-CHG-OH FMOC-D-CHG-OH FMOC-D-HOMOPHENYLALANINE 9-Fluorenylmethyl carbamate FMOC-CHA-OH FMOC-L-HOMOPHENYLALANINE FMOC-D-NLE-OH Fmoc-L-Glutamic acid 1-tert-butyl ester FMoc-NH-5(ethylene glycol)-acetic acid FMOC-11-AMINOUNDECANOIC ACID Fmoc-O-tert-butyl-D-threonine FMoc-sarcosine Hydrate FMOC-HOMOARG-OH

FMOC-NH-(CH2)5-COOH

FMOC-AMINOCAPROIC ACID

FMOC-AHX(6)-OH

FMOC-ACP-OH

FMOC-ACP(6)-OH

FMOC-6-ACA-OH

FMOC-6-AHX-OH

FMOC-6-AMINOCAPROIC ACID

FMOC-6-AMINOHEXANOIC ACID

FMOC-EPSILON-AHX-OH

FMOC-EPSILON-AMINOCAPROIC ACID

FMOC-EPSILON-ACP-OH

6-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)HEXANOIC ACID

6-(FMOC-AMINO)CAPROIC ACID

6-(FMOC-AMINO)HEXANOIC ACID

9-FLUORENYLMETHOXYCARBONYL-6-AMINOCAPROIC ACID

9-FLUORENYLMETHOXYCARBONYL-EPSILON-AMINOHEXANOIC ACID

6-amino-2-[9H-fluoren-9-ylmethoxy(oxo)methyl]hexanoic acid

Fmoc-6-Ahx-OH >=97.0% (HPLC)

6-(Fmoc-amino)caproic acid, 6-(Fmoc-amino)hexanoic acid

N-(9-Fluorenylmethyloxycarbonyl)-epsilon-amino-capronic acid, N-(9-Fluorenylmethyloxycarbonyl)-6-aminohexanoic acid

Fmoc-6-aminohexanoic acid (Fmoc-6-Ahx-OH) ,98.5%(HPLC)

FMoc-6-Ahx-OH(FMoc-6-aMinohexanoic acid)

FMoc-ε- AMinocaproic acid FMoc-ε- AMinocaproic acid

FMoc-6-aMinohexanoic acid, FMoc-eAhx-OH

FMoc-e-aMinocaproic acid

NALPHA-9-Fluorenylmethoxycarbonyl-6-aminohexanoic acid

N-(9-Fluorenylmethyloxycarbonyl)-epsilon-amino-caproic acid, N-(9-Fluorenylmethyloxycarbonyl)-6-aminohexanoic acid

Fmoc-e-Acp-OH

N-EPSILON-FMOC-AMINOHEXANOIC ACID

N-EPSILON-FMOC-EPSILON-AMINOCAPROIC ACID

N-(9-FLUORENYLMETHYLOXYCARBONYL)-6-AMINOHEXANOIC ACID

N-(9-FLUORENYLMETHYLOXYCARBONYL)-EPSILON-AMINO-CAPROIC ACID

N-FMOC-6-AMINOHEXANOIC ACID

RARECHEM EM WB 0023

(9H-Fluoren-9-yl)MethOxy]Carbonyl e-Acp-OH

Fmoc-6-aminohexanoic acid≥ 99% (HPLC)

Fmoc-ε-Ahx-OH Novabiochem

Hexanoic acid, 6-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-

FMOC-6-AMINOHEXANOIC ACID USP/EP/BP

N-Fluorenemethoxycarbonyl-6-aminohexanoic acid

6-(Fmoc-amino)caproic acid,97%

Fmoc-6-Ahx-OH - 5 g

Fmoc-6-Aca

88574-06-5

88574-08-5

Unnatural Amino Acid Derivatives

Linear Core Amino Acids

Specialty Synthesis

Peptide Synthesis

Unusual Amino Acids

Amino Acid Derivatives

Amino Acids