FMOC-NLE-OH
- Product Name
- FMOC-NLE-OH
- CAS No.
- 77284-32-3
- Chemical Name
- FMOC-NLE-OH
- Synonyms
- FMOC-NLE;FMOC-NLE-OH;FMOC-L-NLE-OH;FMOC-AHX(2)-OH;FMOC-NORLEUCINE;FMOC-ACPO(2)-OH;FMOC-NLE-OH 98+%;FMOC-L-NORLEUCINE;RARECHEM EM WB 0166;N-FMOC-L-NORLEUCINE
- CBNumber
- CB7225457
- Molecular Formula
- C21H23NO4
- Formula Weight
- 353.41
- MOL File
- 77284-32-3.mol
FMOC-NLE-OH Property
- Melting point:
- 141-144 °C(lit.)
- alpha
- -18.5 º (C=1 IN DMF)
- Boiling point:
- 565.6±33.0 °C(Predicted)
- Density
- 1.209±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 3.91±0.21(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- optical activity
- [α]20/D 18±1°, c = 1% in DMF
- BRN
- 5305164
- CAS DataBase Reference
- 77284-32-3(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2924 29 70
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 8.52014
- Product name
- Fmoc-Nle-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $95.9
- Updated
- 2025/07/31
- Product number
- 8.52014
- Product name
- Fmoc-Nle-OH
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $360
- Updated
- 2025/07/31
- Product number
- 8.52014
- Product name
- Fmoc-Nle-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $1110
- Updated
- 2025/07/31
- Product number
- 8.52014
- Product name
- Fmoc-Nle-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $1110
- Updated
- 2025/07/31
- Product number
- 8.52014
- Product name
- Fmoc-Nle-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 1 kg
- Price
- $10130
- Updated
- 2025/07/31
FMOC-NLE-OH Chemical Properties,Usage,Production
Chemical Properties
White crystalline
Uses
Fmoc-Nle-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
947154-63-4
77284-32-3
V-Fmoc allylglycine (100 mg, 0.296 mmol), degassed dichloromethane (6.0 mL), terminal olefins (1.48 mmol, 5 eq.), and HGII catalyst (9.29 mg, 5 mol%) were added to a Schlenk reaction flask equipped with a magnetic stirring bar in a drying oven under nitrogen atmosphere. After sealing the reaction flask, it was removed from the desiccator and connected to a vacuum system. The reaction vial was placed under a stream of nitrogen and the quick assembly stopper was replaced with a sub-seal with a 26-gauge pinhole to ensure a continuous flow of nitrogen across the top of the reaction system. The reaction mixture was stirred overnight at room temperature, followed by evaporation of all dichloromethane. The residue was washed with hexane (2 x 10 mL) and collected by filtration or centrifugation. The resulting residue was redissolved in methanol (10 mL) and transferred to a Fischer-Porter reaction tube. The reaction tube was filled with hydrogen (60 psi), sealed and stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum and the residual brown solid was purified by column chromatography to give the pure Fmoc amino acid analog. Alternatively, the residual brown solid is dissolved in a small amount of ether, the insoluble material is removed by filtration, and the filtrate is concentrated under vacuum to give an off-white solid.
References
[1] Journal of Peptide Science, 2013, vol. 19, # 8, p. 470 - 476
[2] Patent: WO2014/5197, 2014, A1. Location in patent: Page/Page column 48-49
FMOC-NLE-OH Preparation Products And Raw materials
Raw materials
Preparation Products
FMOC-NLE-OH Suppliers
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View Lastest Price from FMOC-NLE-OH manufacturers
- Product
- FMOC-NLE-OH 77284-32-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15
- Product
- FMOC-NLE-OH 77284-32-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15