ChemicalBook > CAS DataBase List > (R)-1-N-Boc-beta-proline

(R)-1-N-Boc-beta-proline

Product Name
(R)-1-N-Boc-beta-proline
CAS No.
72925-16-7
Chemical Name
(R)-1-N-Boc-beta-proline
Synonyms
B67255;BOC-L-B-PROLINE;Boc-D-beta-Proline;(3S)-BOC-BETA-PRO-OH;N-Boc-D-beta-proline;(R)-N-Boc-Beta-Proline;N-Boc-D-^b-proline, 95%;(R)-1-N-Boc-beta-proline;(S)-1-N-BOC-BETA-PROLINE;R-Boc-Pyrrolidine-3-carboxylic
CBNumber
CB7225932
Molecular Formula
C10H17NO4
Formula Weight
215.25
MOL File
72925-16-7.mol
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(R)-1-N-Boc-beta-proline Property

Melting point:
138-143°C
Boiling point:
337.2±35.0 °C(Predicted)
Density 
1.201±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in Dimethyl sulfoxide (DMSO).
form 
solid
pka
4.47±0.20(Predicted)
color 
White to off-white
optical activity
[α]/D -15.0, c = 0.5% in chloroform
InChI
InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m1/s1
InChIKey
HRMRQBJUFWFQLX-SSDOTTSWSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC[C@@H](C(O)=O)C1
CAS DataBase Reference
72925-16-7(CAS DataBase Reference)
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Safety

Hazard Codes 
N
Risk Statements 
36/37/38-50
Safety Statements 
26-36/37/39-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
735493
Product name
(R)-1-Boc-3-pyrrolidinecarboxylic acid
Purity
97%
Packaging
500mg
Price
$113.97
Updated
2025/07/31
TRC
Product number
B809535
Product name
(R)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxylicAcid
Packaging
500mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
S922
Product name
(R)-1-Boc-3-carboxylpyrrolidine
Packaging
250mg
Price
$26
Updated
2021/12/16
ChemScene
Product number
CS-B0422
Product name
(R)-1-N-Boc-beta-proline
Purity
≥97.0%
Packaging
1g
Price
$38
Updated
2021/12/16
AK Scientific
Product number
J93496
Product name
(R)-1-Boc-3-carboxylpyrrolidine
Packaging
1g
Price
$49
Updated
2021/12/16
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(R)-1-N-Boc-beta-proline Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

122684-33-7

72925-16-7

General procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) solution of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol). . The reaction mixture was allowed to react for 3 hours with stirring at room temperature. After the reaction was completed, the methanol was removed by concentration under reduced pressure. The pH of the remaining solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic phases were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of an oily product in 83.00% yield.

References

[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059

(R)-1-N-Boc-beta-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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72925-16-7, (R)-1-N-Boc-beta-prolineRelated Search:

(S)-1-N-BOC-BETA-PROLINE 1-(tert-Butoxycarbonyl)-3-pyrrolidinol (R)-1-Boc-3-Hydroxypiperidine BOC-1,3-CIS-ACHC-OH CYCLOHEXANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, (1R,3S)- (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE (R)-1-N-BOC-BETA-PROLINE 1-Boc-Pyrrolidine (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester (S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester R/S-1-N-BOC-BETA-PROLINE 1-N-BOC-BETA-PROLINE

  • (S)-1-N-BOC-BETA-PROLINE
  • S-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID
  • (S)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • BOC-L-B-PROLINE
  • BOC-(3S)-1-PYRROLIDINE-3-CARBOXYLIC ACID
  • (3S)-BOC-1-PYRROLIDINE-3-CARBOXYLIC ACID
  • (3S)-BOC-BETA-PRO-OH
  • (3R)-1-(tertbutoxycarbonyl)pyrrolidine-3-carboxylic acid
  • (R)-1-N-BOC-PYRROLIDINE-3-CARBOXYLICACID
  • (R)-1-Boc-pyrrolidine-3-carboxylic acid
  • (R)-1-N-Boc-beta-proline
  • (R)-1-tert-Butoxycarbonyl-pyrrolidine-3-carboxylic acid
  • (S)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid
  • B67255
  • R-Boc-Pyrrolidine-3-carboxylic
  • N-Boc-D-beta-proline
  • N-Boc-R-3-Pyrrolidinecarboxylic acid
  • (R)-N-Boc-Beta-Proline
  • (3R)-1,3-Pyrrolidinedicarboxylic acid 1-(tert-butyl) ester
  • N-Boc-D-^b-proline, 95%
  • (R)-1-(t-butoxycarbonyl)-3-pyrrolidinocarboxylic acid
  • (R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
  • 1,3-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3R)-
  • (3R)-1-Boc-3-pyrrolidinecarboxylic acid
  • 1-N-Boc-pyrrolidine-3(R)-carboxylic acid
  • (R)-1-Boc-3-Carboxyl pyrrolidine
  • (3R)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid
  • Boc-D-beta-Proline
  • 1-(1,1-Dimethylethyl) (3R)-1,3-pyrrolidinedicarboxylate
  • Boc(R)-1-Boc-3-pyrrolidinecarboxylic acid
  • (R)-1-N-Boc-beta-proline, CAS 72925-16-7
  • Boc-(3R)-1-pyrrolidine-3-carboxylic acid
  • 1-(tert-Butyl) (3R)-1,3-pyrrolidinedicarboxylate
  • 72925-16-7
  • pharmacetical
  • Pyrrole&Pyrrolidine&Pyrroline